Mapping fiber orientation in human muscle by proton MR spectroscopic imaging

Vermathen, Peter; Boesch, Chris; Kreis, Roland

doi:10.1002/mrm.10396

Cited by 58 publications

(84 citation statements)

References 40 publications

(76 reference statements)

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“…Fiber orientation has been measured by spectroscopic methods and is based on the fact that some resonances show orientation-dependent dipolar splitting caused by incomplete motional averaging (15). Fiber orientation is defined with respect to the z-axis of the magnet (corresponding to the subject's SI axis).…”

Section: Discussionmentioning

confidence: 99%

“…The following parameters were extracted for each ROI: eigenvalues ( 1 , 2 , 3 ), mean diffusivity ( av ), FA, and the angle made by the muscle fiber (specified by the eigenvector corresponding to the primary eigenvalue) with the SI axis of subject (z-axis in magnet frame). The ROI locations and the imaging slice were chosen so that comparisons between the current DTI data and those from earlier studies using DTI and spectroscopy would be meaningful (11,15).…”

Section: Image Analysismentioning

confidence: 99%

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In vivo diffusion tensor imaging of the human calf muscle

Sinha¹,

Sinha²,

Edgerton³

2006

Magnetic Resonance Imaging

157

133

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Purpose:To demonstrate the feasibility of in vivo calf muscle fiber tracking in human subjects. Materials and Methods:An EPI-based diffusion tensor imaging (DTI) sequence with six-direction diffusion gradient sensitization was implemented, and DT images were acquired at 3 Tesla on five subjects using an extremity coil. The mean diffusivity, fractional anisotropy (FA), and fiber angle (with respect to the magnet z-axis) were measured in different muscles, and fibers were tracked from several regions of interest (ROIs). Results:The fiber orientations in the current DTI studies agree well with those determined in previous spectroscopic studies. The orientation angles ranged from 13.4°in the lateral gastrocnemius to 48.5°in the medial soleus. The diffusion ellipsoid in muscle tissue is anisotropic and approximates a prolate model, as shown by color maps of the anisotropy. Fibers were tracked from the different muscle regions, and the unipennate and bipennate structure of muscle fibers was visualized. Conclusion:The study clearly shows that in vivo fiber tracking of muscle fibers is feasible and could potentially be applied to study muscle structure function relationships.Key Words: muscle diffusion tensor imaging; diffusion anisotropy; fiber orientation; muscle fiber tracts; 3T in vivo muscle DTI

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Section: Discussionmentioning

confidence: 99%

Section: Image Analysismentioning

confidence: 99%

In vivo diffusion tensor imaging of the human calf muscle

Sinha¹,

Sinha²,

Edgerton³

2006

Magnetic Resonance Imaging

157

133

View full text Add to dashboard Cite

show abstract

“…Besides the direct influences as mentioned above, numerous publications reported a potential influence of other factors upon IMCL levels, such as short-term training (61), oxygenation (62,63), age (64), gender (65)(66)(67), obesity (68), training status (61), muscle group (51,69) or pennation angle (70). A summary of all physiological and pathophysiological consequences of the factors mentioned above would go beyond the target of this text; however, it is important to be aware of all potential factors if a study is not to be influenced by uncontrolled, concomitant factors.…”

Section: Various Other Influences Upon Imcl Levelsmentioning

confidence: 99%

Role of proton MR for the study of muscle lipid metabolism

et al. 2006

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1 H-MR spectroscopy (MRS) of intramyocellular lipids (IMCL) became particularly important when it was recognized that IMCL levels are related to insulin sensitivity. While this relation is rather complex and depends on the training status of the subjects, various other influences such as exercise and diet also influence IMCL concentrations. This may open insight into many metabolic interactions; however, it also requires careful planning of studies in order to control all these confounding influences. This review summarizes various historical, methodological, and practical aspects of 1 H-MR spectroscopy (MRS) of muscular lipids. That includes a differentiation of bulk magnetic susceptibility effects and residual dipolar coupling that can both be observed in MRS of skeletal muscle, yet affecting different metabolites in a specific way. Fitting of the intra-(IMCL) and extramyocellular (EMCL) signals with complex line shapes and the transformation into absolute concentrations is discussed. Since the determination of IMCL in muscle groups with oblique fiber orientation or in obese subjects is still difficult, potential improvement with high-resolution spectroscopic imaging or at higher field strength is considered. Fat selective imaging is presented as a possible alternative to MRS and the potential of multinuclear MRS is discussed. 1 H-MRS of muscle lipids allows non-invasive and repeated studies of muscle metabolism that lead to highly relevant findings in clinics and patho-physiology.

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“…However, definite proof that this also explains the in vivo observations is still lacking. Vermathen et al (108) have elegantly made use of the residual coupling effect to map the local fiber orientation in human skeletal muscle on the basis of 1 H spectroscopic imaging data.…”

mentioning

confidence: 99%

Dynamic MRS and MRI of skeletal muscle function and biomechanics

et al. 2006

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MR is a powerful technique for studying the biomechanical and functional properties of skeletal muscle in vivo in health and disease. This review focuses on 31 P, 1 H and 13 C MR spectroscopy for assessment of the dynamics of muscle metabolism and on dynamic 1 H MRI methods for non-invasive measurement of the biomechanical and functional properties of skeletal muscle. The information thus obtained ranges from the microscopic level of the metabolism of the myocyte to the macroscopic level of the contractile function of muscle complexes. The MR technology presented plays a vital role in achieving a better understanding of many basic aspects of muscle function, including the regulation of mitochondrial activity and the intricate interplay between muscle fiber organization and contractile function. In addition, these tools are increasingly being employed to establish novel diagnostic procedures as well as to monitor the effects of therapeutic and lifestyle interventions for muscle disorders that have an increasing impact in modern society.

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Mapping fiber orientation in human muscle by proton MR spectroscopic imaging

Cited by 58 publications

References 40 publications

In vivo diffusion tensor imaging of the human calf muscle

In vivo diffusion tensor imaging of the human calf muscle

Role of proton MR for the study of muscle lipid metabolism

Dynamic MRS and MRI of skeletal muscle function and biomechanics

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