Mapping crossover events of mouse meiotic recombination by restriction fragment ligation-based Refresh-seq
Yan Wang,
Yijun Chen,
Junpeng Gao
et al.
Abstract:Single-cell whole-genome sequencing methods have undergone great improvements over the past decade. However, allele dropout, which means the inability to detect both alleles simultaneously in an individual diploid cell, largely restricts the application of these methods particularly for medical applications. Here, we develop a new single-cell whole-genome sequencing method based on third-generation sequencing (TGS) platform named Refresh-seq (restriction fragment ligation-based genome amplification and TGS). I… Show more
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