Mapping Cortical Activations Underlying Naturalistic Language Generation Without Motion Censoring Using HD-DOT

Schroeder, Mariel L.; Sherafati, Arefeh; Ulbrich, Rachel L.; Fishell, Andrew K.; Svoboda, Alexandra M.; Culver, Joseph P.; Eggebrecht, Adam T.

doi:10.1364/ots.2020.stu2d.6

Cited by 2 publications

(4 citation statements)

References 7 publications

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“…Source-detector (SD) pair light level measurements were converted to log-ratio by calculating the temporal mean of a given SD-pair measurement as the baseline for that measurement. Noisy measurements were empirically defined as those that have greater than 7.5% temporal standard deviation in the least noisy (lowest mean motion) 60 seconds of each run (Eggebrecht, Ferradal et al 2014, Sherafati, Snyder et al 2020). Then, channels with greater than 33% noisy first or second nearest neighbor measurements (nn1 and nn2) were excluded ( Fig.…”

Section: Methodsmentioning

confidence: 99%

“…To define the left and right auditory ROIs, we used a previously published fMRI resting state dataset (Sherafati, Snyder et al 2020) that was masked by the field of view of our HD-DOT system. We defined the left and right auditory ROIs by selecting a 5 mm radius seed in the contralateral hemisphere ([70.5, -24, 3], [-67.5, -27, 3]) and finding the Pearson correlation between the time-series of the seed region with all other voxels in the field of view.…”

Section: Methodsmentioning

confidence: 99%

“…Thus, optical brain imaging (Peelle 2017) has become a method of choice for studying functional activity in CI listeners (Lawler, Wiggins et al 2015, Olds, Pollonini et al 2016, Anderson, Wiggins et al 2017, Lawrence, Wiggins et al 2018, Zhou, Seghouane et al 2018). In the current study, we use highdensity diffuse optical tomography (HD-DOT) (Eggebrecht, Ferradal et al 2014), previously validated in speech studies in listeners with normal hearing (Hassanpour, Eggebrecht et al 2015, Hassanpour, Eggebrecht et al 2017, Schroeder, Sherafati et al 2020. HD-DOT provides high spatial resolution and homogenous sensitivity over the field of view that captures known speechrelated brain regions (White and Culver 2010).…”

Section: Introductionmentioning

confidence: 99%

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Prefrontal cortex supports speech perception in listeners with cochlear implants

Sherafati

Dwyer

Bajracharya

et al. 2021

Preprint

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Cochlear implants are neuroprosthetic devices that can restore hearing in individuals with severe to profound hearing loss by electrically stimulating the auditory nerve. Because of physical limitations on the precision of this stimulation, the acoustic information delivered by a cochlear implant does not convey the same level of spectral detail as that conveyed by normal hearing. As a result, speech understanding in listeners with cochlear implants is typically poorer and more effortful than in listeners with normal hearing. The brain networks supporting speech understanding in listeners with cochlear implants are not well understood, partly due to difficulties obtaining functional neuroimaging data in this population. In the current study, we assessed the brain regions supporting spoken word understanding in adult listeners with right unilateral cochlear implants (n=20) and matched controls (n=18) using high-density diffuse optical tomography (HD-DOT), a quiet and non-invasive imaging modality with spatial resolution comparable to that of functional MRI. We found that while listening to spoken words in quiet, listeners with cochlear implants showed greater activity in the left dorsolateral prefrontal cortex, overlapping with functionally-defined domain-general processing seen in a spatial working memory task. These results suggest that listeners with cochlear implants require greater cognitive processing during speech understanding than listeners with normal hearing, supported by compensatory recruitment in the left dorsolateral prefrontal cortex.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prefrontal cortex supports speech perception in listeners with cochlear implants

Sherafati

Dwyer

Bajracharya

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Thus, optical brain imaging ( Peelle, 2017 ) has become a method of choice for studying functional activity in CI listeners ( Anderson et al, 2017 ; Lawler et al, 2015 ; Lawrence et al, 2018 ; Olds et al, 2016 ; Zhou et al, 2018 ). In the current study, we use high-density diffuse optical tomography (HD-DOT) ( Eggebrecht et al, 2014 ; Zeff et al, 2007 ), previously validated in speech studies in listeners with normal hearing ( Hassanpour et al, 2015 ; Hassanpour et al, 2017 ; Schroeder et al, 2020 ). HD-DOT provides high spatial resolution and homogenous sensitivity over a field of view that captures known speech-related brain regions ( White and Culver, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Prefrontal cortex supports speech perception in listeners with cochlear implants

Sherafati

Dwyer

Bajracharya

et al. 2022

eLife

Self Cite

View full text Add to dashboard Cite

Cochlear implants are neuroprosthetic devices that can restore hearing in people with severe to profound hearing loss by electrically stimulating the auditory nerve. Because of physical limitations on the precision of this stimulation, the acoustic information delivered by a cochlear implant does not convey the same level of acoustic detail as that conveyed by normal hearing. As a result, speech understanding in listeners with cochlear implants is typically poorer and more effortful than in listeners with normal hearing. The brain networks supporting speech understanding in listeners with cochlear implants are not well understood, partly due to difficulties obtaining functional neuroimaging data in this population. In the current study, we assessed the brain regions supporting spoken word understanding in adult listeners with right unilateral cochlear implants (n=20) and matched controls (n=18) using high-density diffuse optical tomography (HD-DOT), a quiet and non-invasive imaging modality with spatial resolution comparable to that of functional MRI. We found that while listening to spoken words in quiet, listeners with cochlear implants showed greater activity in the left prefrontal cortex than listeners with normal hearing, specifically in a region engaged in a separate spatial working memory task. These results suggest that listeners with cochlear implants require greater cognitive processing during speech understanding than listeners with normal hearing, supported by compensatory recruitment of the left prefrontal cortex.

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Mapping Cortical Activations Underlying Naturalistic Language Generation Without Motion Censoring Using HD-DOT

Abstract: This study measures cortical activity underlying covert and overt verb generation using high-density diffuse optical tomography (HD-DOT). Results demonstrate HD-DOT captures activations comparable to fMRI and is resistant to speech-related motion artifact.

Cited by 2 publications

References 7 publications

Prefrontal cortex supports speech perception in listeners with cochlear implants

Prefrontal cortex supports speech perception in listeners with cochlear implants

Prefrontal cortex supports speech perception in listeners with cochlear implants

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