Mapping clinically relevant plasticity after stroke

Cramer, Steven C.; Bastings, E.

doi:10.1016/s0028-3908(99)00258-0

Cited by 165 publications

(96 citation statements)

References 62 publications

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“…Depending on the kind of functional deficit, individual tasks can be designed to pinpoint where brain activity is impaired and how the ischemic brain has adapted to the injury, which makes fMRI a complementary imaging surrogate to infarct size measurements. As to reorganization of motor function after stroke, several general patterns of fMRI activity changes have been observed, reviewed elsewhere (Calautti and Baron, 2003;Carey and Seitz, 2007;Cramer and Bastings, 2000;Grefkes and Fink, 2009). Activity significantly increases in motor-related and peri-infarct areas, and tasks performed by the impaired hand produce bilateral cortical activation, including regions not activated in intact patients.…”

Section: Functional Mrimentioning

confidence: 99%

Use of Magnetic Resonance Imaging to Predict Outcome after Stroke: A Review of Experimental and Clinical Evidence

Farr

Wegener

2010

J Cereb Blood Flow Metab

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Despite promising results in preclinical stroke research, translation of experimental data into clinical therapy has been difficult. One reason is the heterogeneity of the disease with outcomes ranging from complete recovery to continued decline. A successful treatment in one situation may be ineffective, or even harmful, in another. To overcome this, treatment must be tailored according to the individual based on identification of the risk of damage and estimation of potential recovery. Neuroimaging, particularly magnetic resonance imaging (MRI), could be the tool for a rapid comprehensive assessment in acute stroke with the potential to guide treatment decisions for a better clinical outcome. This review describes current MRI techniques used to characterize stroke in a preclinical research setting, as well as in the clinic. Furthermore, we will discuss current developments and the future potential of neuroimaging for stroke outcome prediction.

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Section: Functional Mrimentioning

confidence: 99%

Use of Magnetic Resonance Imaging to Predict Outcome after Stroke: A Review of Experimental and Clinical Evidence

Farr

Wegener

2010

J Cereb Blood Flow Metab

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“…Accurate and detailed somatotopic mapping of the human body surface will improve basic understanding of the somatosensory system, guide neurosurgical planning, and assess plasticity and recovery after brain damage or body injuries (Borsook et al, 1998;Corbetta et al, 2002;Cramer et al, , 2003Cramer and Bastings, 2000;Cramer and Crafton, 2006;Lee et al, 1998Lee et al, , 1999Moore et al, 2000b;Ramachandran, 2005;Ramachandran and Rogers-Ramachandran, 2000;Rijntjes et al, 1997). Studies using fMRI have revealed somatotopic representations of the hand, fingers, wrist, elbow, shoulder, foot, toes, lips, and tongue in human brains (Alkadhi et al, 2002;Beisteiner et al, 2001;Blankenburg et al, 2003;Dechent and Frahm, 2003;Francis et al, 2000;Gelnar et al, 1998;Golaszewski et al, 2006;Hanakawa et al, 2005;Hlustik et al, 2001;Kurth et al, 2000;Lotze et al, 2000;McGlone et al, 2002;Miyamoto et al, 2006;Moore et al, 2000a;Overduin and Servos, 2004;Ruben et al, 2001;Servos et al, 1998;Stippich et al, 1999Stippich et al, , 2004van Westen et al, 2004; also see reviews in Burton, 2002).…”

Section: Introductionmentioning

confidence: 99%

Dodecapus: An MR-compatible system for somatosensory stimulation

Huang

Sereno

2007

NeuroImage

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Somatotopic mapping of human body surface using fMRI is challenging. First, it is difficult to deliver tactile stimuli in the scanner. Second, multiple stimulators are often required to cover enough area of the complex-shaped body surface, such as the face. In this study, a computer-controlled pneumatic system was constructed to automatically deliver air puffs to 12 locations on the body surface through an MR-compatible manifold (Dodecapus) mounted on a head coil inside the scanner bore. The timing of each air-puff channel is completely programmable and this allows systematic and precise stimulation on multiple locations on the body surface during functional scans. Three two-condition block-design "Localizer" paradigms were employed to localize the cortical representations of the face, lips, and fingers, respectively. Three "Phase-encoded" paradigms were employed to map the detailed somatotopic organizations of the face, lips, and fingers following each "Localizer" paradigm. Multiple somatotopic representations of the face, lips, and fingers were localized and mapped in primary motor cortex (MI), ventral premotor cortex (PMv), polysensory zone (PZ), primary (SI) and secondary (SII) somatosensory cortex, parietal ventral area (PV) and 7b, as well as anterior and ventral intraparietal areas (AIP and VIP). The Dodecapus system is portable, easy to setup, generates no radio frequency interference, and can also be used for EEG and MEG experiments. This system could be useful for non-invasive somatotopic mapping in both basic and clinical studies.

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“…fMRI was adapted to identify the blood flow changes and cortical activation sites during performance of various sensoriomotor tasks, due to its good spatial resolution in the cortex 16,17) . As results, Blood-oxygen-level-dependent (BOLD) signal activities were observed bilaterally in the primary sensoriomotor cortex (SM1) and the inferior parietal cortex (IPC).…”

Section: Discussionmentioning

confidence: 99%

Cortical Activation Pattern according to Discrimination of One-Point and Two-Point Tactile Sensory Inputs: an fMRI Study

Park

Kwon²

2012

J Phys Ther Sci

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Abstract.[Purpose] The aim of this study was to investigate which of cortical areas are precisely involved in performing the two-point discrimination task (TPD), using functional magnetic resonance image (fMRI). [Subjects and Methods] Nine healthy right-handed subjects were recruited. During fMRI scanning, tactile sensory stimulation of one-or two-points was conducted on the dominant thumb with a two-point discriminator. At that time, The subject pressed a corresponding button when perceived one point or two points, corresponding to the two types of delivered tactile stimulation. [Results] In group analysis, the averaged cortical maps showed that the left and right primary sensory cortices and inferior parietal cortices were activated. In the bilateral primary sensory cortex, the peak intensities were 7.34 and 5.14, in the left and right hemispheres, respectively. In addition, the left and right inferior parietal cortices were activated, and the peak intensities were 4.30 and 6.18, respectively. [Conclusion] Our results revealed that the performance of a TPD task is likely to require the higher order sensory discriminative modality which is processed by the cortical cognitive function. In addition, the neural processing of TPD was specifically associated with bilateral activity in the inferior parietal cortex.

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Mapping clinically relevant plasticity after stroke

Cited by 165 publications

References 62 publications

Use of Magnetic Resonance Imaging to Predict Outcome after Stroke: A Review of Experimental and Clinical Evidence

Use of Magnetic Resonance Imaging to Predict Outcome after Stroke: A Review of Experimental and Clinical Evidence

Dodecapus: An MR-compatible system for somatosensory stimulation

Cortical Activation Pattern according to Discrimination of One-Point and Two-Point Tactile Sensory Inputs: an fMRI Study

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