Mapping Brain Microstructure and Network Alterations in Depressive Patients with Suicide Attempts Using Generalized Q-Sampling MRI

Chen, Vincent Chin‐Hung; Kao, C. C.; Tsai, Yuan-Hsiung; McIntyre, Roger S.; Weng, Jun‐Cheng

doi:10.3390/jpm11030174

Cited by 7 publications

(6 citation statements)

References 67 publications

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“…In addition, SA showed reduced activation in the OFC for the contrast between disadvantageous and advantageous choices (Jollant et al, 2010). Other authors (Kaschka & Rujescu, 2016;Zhang et al, 2019) have reported in SA structural alterations in CC and deficits in emotion regulation and impulse control (Cyprien et al, 2011;Emsell et al, 2013;Gan et al, 2016;Matsuo et al, 2010) It has been suggested that WM abnormalities also play a critical role in the pathogenesis of psychiatric disorders (Chen et al, 2021). DTI studies revealed disrupted connectivity within the DMN accompanying mood disorders (Hamilton et al, 2015) and rumination (Berman et al, 2011;Lois & Wessa, 2016).…”

Section: Discussionmentioning

confidence: 91%

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Diffusion tensor imaging studies on subjects with suicidal thoughts and behaviors: A descriptive literature review

2022

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Objective Globally, suicide represents the second leading cause of death in young people aged 15–29 years for both sexes, after traffic accidents. Suicide occurs not only in high‐income countries, in high‐income countries but it is a global phenomenon in all regions of the world and it represents a serious public health problem. Method This review was conducted on studies focused on white matter alterations in people who have attempted or thought about suicide. We searched PubMed and Scopus databases and screened references of included studies and reviewed articles for additional citations. From the initial 21 publications, we included only 12 studies that met search criteria and described the association between white matter alterations and suicide. Results White matter alterations in suicidal behaviors were found in the prefrontal cortex, orbitofrontal cortex, internal capsule, corpus callosum, and default mode networks, which are critical cerebral areas involved in emotion processing and regulation, decision‐making, executive functions, and empathy. Conclusions White matter alteration in cerebral areas involving high cognitive process and emotional regulation to confer a heightened vulnerability for suicidal behavior. Suicide is a complex process ranging from suicidal ideation to planning, attempting, or committing suicide. The identification of abnormalities in underlying neural circuitry may help delineate the neurobiological basis for suicide risk.

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Section: Discussionmentioning

confidence: 91%

“…It has been suggested that WM abnormalities also play a critical role in the pathogenesis of psychiatric disorders (Chen et al., 2021 ). DTI studies revealed disrupted connectivity within the DMN accompanying mood disorders (Hamilton et al., 2015 ) and rumination (Berman et al., 2011 ; Lois & Wessa, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Diffusion tensor imaging studies on subjects with suicidal thoughts and behaviors: A descriptive literature review

2022

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“…A 2021 study by Chen et al evaluated white-matter integrity (generalized fractional anisotropy) and white-matter compactness (normalized quantitative anisotropy) among depressive patients with and without past suicide attempts ( 96 ). On a voxel-based (region of interest) analysis, participants with past suicide attempts had significantly lower white matter compactness and integrity in the corpus callosum, cingulate gyrus, and caudate than both the depressed non-attempt and the healthy control groups, with differences between the attempt group and healthy control group reaching statistical significance ( 96 ).…”

Section: Resultsmentioning

confidence: 99%

Neuroimaging alterations of the suicidal brain and its relevance to practice: an updated review of MRI studies

Dobbertin¹,

Blair²,

Carollo³

et al. 2023

Front. Psychiatry

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Suicide is a leading cause of death in the United States. Historically, scientific inquiry has focused on psychological theory. However, more recent studies have started to shed light on complex biosignatures using MRI techniques, including task-based and resting-state functional MRI, brain morphometry, and diffusion tensor imaging. Here, we review recent research across these modalities, with a focus on participants with depression and Suicidal Thoughts and Behavior (STB). A PubMed search identified 149 articles specific to our population of study, and this was further refined to rule out more diffuse pathologies such as psychotic disorders and organic brain injury and illness. This left 69 articles which are reviewed in the current study. The collated articles reviewed point to a complex impairment showing atypical functional activation in areas associated with perception of reward, social/affective stimuli, top-down control, and reward-based learning. This is broadly supported by the atypical morphometric and diffusion-weighted alterations and, most significantly, in the network-based resting-state functional connectivity data that extrapolates network functions from well validated psychological paradigms using functional MRI analysis. We see an emerging picture of cognitive dysfunction evident in task-based and resting state fMRI and network neuroscience studies, likely preceded by structural changes best demonstrated in morphometric and diffusion-weighted studies. We propose a clinically-oriented chronology of the diathesis-stress model of suicide and link other areas of research that may be useful to the practicing clinician, while helping to advance the translational study of the neurobiology of suicide.

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“…A previous study used DTI for research on white matter integrity to evaluate the value of FA in patients with suicidal ideation. DTI is not able to distinguish branching or crossing bers [40]. To address this limitation, we turned to diffusion kurtosis imaging (DKI), which offers additional metrics closely related to tissue microstructure.…”

Section: Discussionmentioning

confidence: 99%

Macromolecular Proton Fraction and Diffusion Mapping Brain Microstructure in Patients with Major Depressive Disorder: pilot MR trial

Abramova,

Petrovskiy,

Savelov

et al. 2023

Preprint

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In this study, we utilized advanced quantitative MRI techniques, specifically Diffusion Tensor Imaging, Diffusion Kurtosis Imaging, and Мacromolecular Proton Fraction Mapping, to investigate microstructural differences and alterations in the specific regions in patients diagnosed with major depressive disorder. Previous studies have illustrated that the cingulate and prefrontal gyrus, along with the amygdala, are involved in emotional processing and the development of abnormal emotional responses in depression. Our findings revealed no significant interaction between Мacromolecular proton fraction Mapping with depressive disorder. However, patients with major depressive disorder exhibited a statistically significant increase in mean, axial and radial diffusivity (F = 6.3, p = 0.01, F = 5.0, p = 0.03, F = 7.08, p = 0.01, respectively) in the bilateral amygdala compared to healthy controls, as well as in mean and radial diffusivity in the anterior cingulate cortex (F = 5.61, p = 0.02, F = 7.08, p = 0.01, respectively). These results suggest that altered molecular diffusion characteristics in the amygdala and the anterior cingulate cortex may be specifically associated with major depressive disorder. The identification of novel markers for brain microstructural changes could have implications for early prediction of depressive disorder. Our study demonstrates the utility of new quantitative MRI techniques in assessing structural alterations on the molecular level in the brain and enhances our understanding of the pathophysiology of depression.

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Mapping Brain Microstructure and Network Alterations in Depressive Patients with Suicide Attempts Using Generalized Q-Sampling MRI

Cited by 7 publications

References 67 publications

Diffusion tensor imaging studies on subjects with suicidal thoughts and behaviors: A descriptive literature review

Diffusion tensor imaging studies on subjects with suicidal thoughts and behaviors: A descriptive literature review

Neuroimaging alterations of the suicidal brain and its relevance to practice: an updated review of MRI studies

Macromolecular Proton Fraction and Diffusion Mapping Brain Microstructure in Patients with Major Depressive Disorder: pilot MR trial

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