Mapping brain Fos immunoreactivity in response to water deprivation and partial rehydration: Influence of sodium intake

Dalmasso, Carolina; Antunes‐Rodrigues, José; Vivas, Laura; Luca, Laurival A. De

doi:10.1016/j.physbeh.2015.08.020

Cited by 11 publications

(4 citation statements)

References 40 publications

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“…Together, these results indicate that CeL Sst + and CeL Crh + Nts + Tac2 + neurons are positive mediators of appetitive behavior and mainly participate in drinking-related function. These results bring insight to previous studies that have implicated the CeL in drinking and alcohol-related behaviors (Dalmasso et al, 2015; Hwang et al, 2004; Kissler et al, 2014; Nie et al, 2004; Pereira-Derderian et al, 2010). With regard to the function of the two types of Prkcd − neurons, examination of CeL Sst + and CeL Crh + Nts + Tac2 + neurons revealed no functional, behavioral, or connectivity differences.…”

Section: Discussionsupporting

confidence: 80%

Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors

Kim

Zhang

Muralidhar

et al. 2017

Neuron

367

493

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Summary Basolateral amygdala (BLA) principle cells are capable of driving and antagonizing behaviors of opposing valence. BLA neurons project to the central amygdala (CeA), which also participates in negative and positive behaviors. However, the CeA has primarily been studied as the site for negative behaviors and the causal role for CeA circuits underlying appetitive behaviors is poorly understood. Here we identified several genetically distinct populations of CeA neurons that mediate appetitive behaviors and dissected the BLA to CeA circuit for appetitive behaviors. Protein phosphatase 1 regulatory subunit 1B+ BLA pyramidal neurons to dopamine receptor 1+ CeA neurons define a pathway for promoting appetitive behaviors, while R-spondin 2+ BLA pyramidal neurons to dopamine receptor 2+ CeA neurons define a pathway for suppressing appetitive behaviors. These data reveal genetically defined neural circuits in the amygdala that promote and suppress appetitive behaviors analogous to the direct and indirect pathway of the basal ganglia.

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Section: Discussionsupporting

confidence: 80%

Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors

Kim

Zhang

Muralidhar

et al. 2017

Neuron

367

493

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“…In addition to stimulating hormone secretion, WD also promotes neuronal activation in the SON, PVN, and CVOs (Morien et al 1999, De Luca et al 2002, Gottlieb et al 2006, Dalmasso et al 2015. In this regard, we showed that the number of Fos immunoreactive neurons is enhanced by WD in the SFO and MnPO, as well as in the vasopressinergic and oxytocinergic neurons of the SON and PVN.…”

Section: :2mentioning

confidence: 56%

Oestradiol effects on neuroendocrine responses induced by water deprivation in rats

Vilhena‐Franco

Mecawi

Elias

2016

Journal of Endocrinology

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Water deprivation (WD) induces changes in plasma volume and osmolality, which in turn activate several responses, including thirst, the activation of the renin-angiotensin system (RAS) and vasopressin (AVP) and oxytocin (OT) secretion. These systems seem to be influenced by oestradiol, as evidenced by the expression of its receptor in brain areas that control fluid balance. Thus, we investigated the effects of oestradiol treatment on behavioural and neuroendocrine changes of ovariectomized rats in response to WD. We observed that in response to WD, oestradiol treatment attenuated water intake, plasma osmolality and haematocrit but did not change urinary volume or osmolality. Moreover, oestradiol potentiated WD-induced AVP secretion, but did not alter the plasma OT or angiotensin II (Ang II) concentrations. Immunohistochemical data showed that oestradiol potentiated vasopressinergic neuronal activation in the lateral magnocellular PVN (PaLM) and supraoptic (SON) nuclei but did not induce further changes in Fos expression in the median preoptic nucleus (MnPO) or subfornical organ (SFO) or in oxytocinergic neuronal activation in the SON and PVN of WD rats. Regarding mRNA expression, oestradiol increased OT mRNA expression in the SON and PVN under basal conditions and after WD, but did not induce additional changes in the mRNA expression for AVP in the SON or PVN. It also did not affect the mRNA expression of RAS components in the PVN. In conclusion, our results show that oestradiol acts mainly on the vasopressinergic system in response to WD, potentiating vasopressinergic neuronal activation and AVP secretion without altering AVP mRNA expression.

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“…The amygdala participates in the fluid intake regulation ( 33 ). Additionally, it has already been shown that WD increases Fos expression in the CeA ( 34 ) and it is well established that BLA ( 35 , 36 ) and CeA ( 37 , 38 ) mediate anxiety-like behavior. However, our data show that Gad1 , Slc17a6, Avpr1a a nd Oxtr mRNA expression are not changed in LHb or BLA after 48 h of WD or SL.…”

Section: Discussionmentioning

confidence: 97%

Water deprivation induces hypoactivity in rats independently of oxytocin receptor signaling at the central amygdala

Felintro

Trujillo²,

Dos‐Santos³

et al. 2023

Front. Endocrinol.

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IntroductionVasopressin (AVP) and oxytocin (OXT) are neuropeptides produced by magnocellular neurons (MCNs) of the hypothalamus and secreted through neurohypophysis to defend mammals against dehydration. It was recently demonstrated that MCNs also project to limbic structures, modulating several behavioral responses.Methods and ResultsWe found that 24 h of water deprivation (WD) or salt loading (SL) did not change exploration or anxiety-like behaviors in the elevated plus maze (EPM) test. However, rats deprived of water for 48 h showed reduced exploration of open field and the closed arms of EPM, indicating hypoactivity during night time. We evaluated mRNA expression of glutamate decarboxylase 1 (Gad1), vesicular glutamate transporter 2 (Slc17a6), AVP (Avpr1a) and OXT (Oxtr) receptors in the lateral habenula (LHb), basolateral (BLA) and central (CeA) amygdala after 48 h of WD or SL. WD, but not SL, increased Oxtr mRNA expression in the CeA. Bilateral pharmacological inhibition of OXTR function in the CeA with the OXTR antagonist L-371,257 was performed to evaluate its possible role in regulating the EPM exploration or water intake induced by WD. The blockade of OXTR in the CeA did not reverse the hypoactivity response in the EPM, nor did it change water intake induced in 48-h water-deprived rats.DiscussionWe found that WD modulates exploratory activity in rats, but this response is not mediated by oxytocin receptor signaling to the CeA, despite the upregulated Oxtr mRNA expression in that structure after WD for 48 h.

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Mapping brain Fos immunoreactivity in response to water deprivation and partial rehydration: Influence of sodium intake

Cited by 11 publications

References 40 publications

Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors

Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors

Oestradiol effects on neuroendocrine responses induced by water deprivation in rats

Water deprivation induces hypoactivity in rats independently of oxytocin receptor signaling at the central amygdala

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