Maporal Hantavirus Causes Mild Pathology in Deer Mice (Peromyscus maniculatus)

McGuire, Amanda L.; Miedema, Kaitlyn; Fauver, Joseph R.; Rico, Amber B.; Aboellail, Tawfik; Quackenbush, Sandra L.; Hawkinson, Ann; Schountz, Tony

doi:10.3390/v8100286

Cited by 11 publications

(9 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Perhaps the best studied virus/reservoir host systems are the rodent-borne hantaviruses, which are similar to arenaviruses, in which the viruses establish apathogenic infections without eliciting aggressive immune responses [ 20 , 21 ]. In each of these systems, the viruses do not cause meaningful pathology and persist for many months or longer, and heterologous hantavirus inoculation of a reservoir host species also results in innocuous infections [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Serological evidence of arenavirus circulation among fruit bats in Trinidad

et al. 2017

Self Cite

View full text Add to dashboard Cite

Tacaribe virus (TCRV) was isolated in the 1950s from artibeus bats captured on the island of Trinidad. The initial characterization of TCRV suggested that artibeus bats were natural reservoir hosts. However, nearly 60 years later experimental infections of Jamaican fruit bats (Artibeus jamaicensis) resulted in fatal disease or clearance, suggesting artibeus bats may not be a reservoir host. To further evaluate the TCRV reservoir host status of artibeus bats, we captured bats of six species in Trinidad for evidence of infection. Bats of all four fruigivorous species captured had antibodies to TCRV nucleocapsid, whereas none of the insectivore or nectarivore species did. Many flat-faced fruit-eating bats (A. planirostris) and great fruit-eating bats (A. literatus) were seropositive by ELISA and western blot to TCRV nucleocapsid antigen, as were two of four Seba’s fruit bats (Carollia perspicillata) and two of three yellow-shouldered fruit bats (Sturnira lilium). Serum neutralization tests failed to detect neutralizing antibodies to TCRV from these bats. TCRV RNA was not detected in lung tissues or lung homogenates inoculated onto Vero cells. These data indicate that TCRV or a similar arenavirus continues to circulate among fruit bats of Trinidad but there was no evidence of persistent infection, suggesting artibeus bats are not reservoir hosts.

show abstract

Section: Discussionmentioning

confidence: 99%

Serological evidence of arenavirus circulation among fruit bats in Trinidad

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Other experiments were dedicated to the analyzing of hantavirus infection in heterologous reservoir species. As such, McGuire et al [54] have shown that Maporal virus (MAPV), a South American hantavirus whose reservoir is the delicate pigmy rice ( Oligoryzomys delicates ), was able to infect deer mice in laboratory conditions. Similarly, de Souza et al [55] have revealed experimentally that Rio Mamore virus (RIOMV), another south American hantavirus naturally infecting Oligoryzomys microtis , was able to infect other Sigmodontinae rodents ( Necromys lasiurus and Akodon sp.…”

Section: Hantavirus Transmission: Modes Dynamics and Spill-overmentioning

confidence: 99%

“…Along this same line, some experiments have been designed to investigate whether hantavirus infections lead to similar or different responses in heterologous reservoir species compared to their natural reservoir. Cross-infections of deer mice have been conducted with ANDV and MAPV, with SNV infections being the reference model [53,54]. Some responses of deer mice were similar, regardless of the hantavirus used.…”

Section: Immune Mechanisms Behind the Biology Of Reservoir/hantavimentioning

confidence: 99%

The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future

Madrières

Castel

Murri

et al. 2019

Viruses

View full text Add to dashboard Cite

Due to their large geographic distribution and potential high mortality rates in human infections, hantaviruses constitute a worldwide threat to public health. As such, they have been the subject of a large array of clinical, virological and eco-evolutionary studies. Many experiments have been conducted in vitro or on animal models to identify the mechanisms leading to pathogenesis in humans and to develop treatments of hantavirus diseases. Experimental research has also been dedicated to the understanding of the relationship between hantaviruses and their reservoirs. However, these studies remain too scarce considering the diversity of hantavirus/reservoir pairs identified, and the wide range of issues that need to be addressed. In this review, we present a synthesis of the experimental studies that have been conducted on hantaviruses and their reservoirs. We aim at summarizing the knowledge gathered from this research, and to emphasize the gaps that need to be filled. Despite the many difficulties encountered to carry hantavirus experiments, we advocate for the need of such studies in the future, at the interface of evolutionary ecology and virology. They are critical to address emerging areas of research, including hantavirus evolution and the epidemiological consequences of individual variation in infection outcomes.

show abstract

“…The answer to this question is likely complicated and will vary between species of bats and species of viruses. In rodent reservoirs of pathogenic hantaviruses, in which the viruses establish persistent infection without meaningful pathology (18)(19)(20)(21)(22), the immune response is slow to develop (21) and is mediated by Fox-p3 + , TGFβ-expressing regulatory T (Treg) cells, which counter inflammatory disease (23,24) but at the expense of sterilizing immunity. Do bats have Treg cells?…”

mentioning

confidence: 99%

Immunological Control of Viral Infections in Bats and the Emergence of Viruses Highly Pathogenic to Humans

et al. 2017

Self Cite

View full text Add to dashboard Cite

Bats are reservoir hosts of many important viruses that cause substantial disease in humans, including coronaviruses, filoviruses, lyssaviruses, and henipaviruses. Other than the lyssaviruses, they do not appear to cause disease in the reservoir bats, thus an explanation for the dichotomous outcomes of infections of humans and bat reservoirs remains to be determined. Bats appear to have a few unusual features that may account for these differences, including evidence of constitutive interferon (IFN) activation and greater combinatorial diversity in immunoglobulin genes that do not undergo substantial affinity maturation. We propose these features may, in part, account for why bats can host these viruses without disease and how they may contribute to the highly pathogenic nature of bat-borne viruses after spillover into humans. Because of the constitutive IFN activity, bat-borne viruses may be shed at low levels from bat cells. With large naive antibody repertoires, bats may control the limited virus replication without the need for rapid affinity maturation, and this may explain why bats typically have low antibody titers to viruses. However, because bat viruses have evolved in high IFN environments, they have enhanced countermeasures against the IFN response. Thus, upon infection of human cells, where the IFN response is not constitutive, the viruses overwhelm the IFN response, leading to abundant virus replication and pathology.

show abstract

Maporal Hantavirus Causes Mild Pathology in Deer Mice (Peromyscus maniculatus)

Cited by 11 publications

References 46 publications

Serological evidence of arenavirus circulation among fruit bats in Trinidad

Serological evidence of arenavirus circulation among fruit bats in Trinidad

The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future

Immunological Control of Viral Infections in Bats and the Emergence of Viruses Highly Pathogenic to Humans

Contact Info

Product

Resources

About