MAPK signaling pathway-targeted marine compounds in cancer therapy

Wei, Jiaen; Liu, Ruining; Hu, Xiyun; Liang, Tingen; Zhou, Zhiran; Huang, Zunnan

doi:10.1007/s00432-020-03460-y

Cited by 32 publications

(24 citation statements)

References 126 publications

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“…Galasso et al explored the current roles of marine microalgae as proposed ingredients for functional foods that possess an advantage in their potential chemopreventive properties [ 234 ], while the review by Shikov indicated that the unique naphthoquinone pigment from sea urchins possesses diverse chemical and pharmacological properties [ 235 ]. In 2020, Wei et al reported that certain marine compounds exert antineoplastic effects on various cancers, including lung cancer, breast cancer, and prostate cancer, through important signaling pathways, such as the PI3K/Akt and MAPK signaling pathways [ 236 , 237 ]. Due to their unique skeletal structures, these marine compounds are very promising for cancer research after being optimized by certain computer-aided drug design pipelines.…”

Section: Discussionmentioning

confidence: 99%

Marine Natural Products in Clinical Use

et al. 2022

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Marine natural products are potent and promising sources of drugs among other natural products of plant, animal, and microbial origin. To date, 20 drugs from marine sources are in clinical use. Most approved marine compounds are antineoplastic, but some are also used for chronic neuropathic pain, for heparin overdosage, as haptens and vaccine carriers, and for omega-3 fatty-acid supplementation in the diet. Marine drugs have diverse structural characteristics and mechanisms of action. A considerable increase in the number of marine drugs approved for clinical use has occurred in the past few decades, which may be attributed to increasing research on marine compounds in laboratories across the world. In the present manuscript, we comprehensively studied all marine drugs that have been successfully used in the clinic. Researchers and clinicians are hopeful to discover many more drugs, as a large number of marine natural compounds are being investigated in preclinical and clinical studies.

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Section: Discussionmentioning

confidence: 99%

Marine Natural Products in Clinical Use

et al. 2022

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“…MAPK signaling pathway was the most noticeable pathway (Figure 6a). The most common MAPK s in humans are extracellular signal‐regulated kinase ( ERK ), c‐Jun N‐terminal kinase ( JNK ), and p38 kinase (Wei et al, 2021). We further detected the expression alteration of MAPK signaling pathway‐related proteins after TOX3 upregulation and downregulation and found significantly increased MEK and ERK1/2 phosphorylation, but not JNK and p38 in HCT116 cells with TOX3 overexpression.…”

Section: Resultsmentioning

confidence: 99%

TOX3 regulates the proliferation and apoptosis of colorectal cancer by downregulating RhoB via the activation of the MAPK pathway

Yang

Liang

et al. 2022

Cell Biology International

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“…NF- κ B is an important transcription regulator in the human body, and it is a protein family composed of multiple polypeptide subunits. p65, I κ B, and p-I κ B are all important members of the NF- κ B family [ 29 , 30 ]. In the current study, our data revealed that KM-AZM attenuated the LPS-induced lung histopathologic changes and inflammatory cytokine production and thus protected mice against LPS-induced induced acute lung injury.…”

Section: Discussionmentioning

confidence: 99%

Combination Therapy with TCM Preparation Kumu Injection and Azithromycin against Bacterial Infection and Inflammation: In Vitro and In Vivo

Yu¹,

Qu³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Azithromycin (AZM) is one of the most common broad-spectrum antibiotics. However, drug resistance is increasing and combination therapy has attracted great attention. AZM is usually combined with traditional Chinese medicine (TCM) preparations with heat-clearing and detoxifying effects, including Kumu injection (KM) made from Picrasma quassioides (D. Don) Benn. Purpose. The present study aimed to investigate synergistic antimicrobial and anti-inflammatory activities of KM plus AZM with the aim of understanding the mechanism of clinical efficacy of combination regimens. Methods. Seven common bacterial clinical isolates and LPS-induced RAW 264.7 cells were used for assay of in vitro potency. The minimum inhibitory concentration (MIC) was determined for each drug, followed by synergy testing through the checkerboard method and fractional inhibitory concentration index (FICI) for quantifying combined antibacterial effects. The rat model of Klebsiella pneumoniae-induced pneumonia was developed and subjected to various drug treatments, namely, AZM, KM, or AZM plus KM, intravenously administered at 75 mg/kg once a day for one week. The combination effects then were evaluated according to pharmacodynamics and pharmacokinetic assessments. Results. KM-AZM combination synergistically inhibits in vitro growth of all the test standard strains except Pseudomonas aeruginosa and also the drug-resistant strains of Staphylococcus aureus, Streptococcus pneumoniae, Shigella dysenteriae, Klebsiella pneumoniae, and Escherichia coli. Despite an additive effect against NO, KM plus AZM at an equal dose could synergistically suppress overrelease of the inflammatory cytokines TNF-α and IL-6 by LPS-induced RAW 264.7 cells. The combination significantly inhibited the proliferation of K. pneumoniae in the rat lungs, mainly by inactivating MAPKs and NF-κB signaling pathways. KM-AZM combination caused a onefold increase in apparent distribution volume of AZM, along with a significant decrease of AZM level in the livers and heart for pharmacokinetics. Conclusion. KM-AZM combination displayed synergistic antibacterial and anti-inflammatory effects beneficial to the therapeutic potential against bacterial infection.

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MAPK signaling pathway-targeted marine compounds in cancer therapy

Cited by 32 publications

References 126 publications

Marine Natural Products in Clinical Use

Marine Natural Products in Clinical Use

TOX3 regulates the proliferation and apoptosis of colorectal cancer by downregulating RhoB via the activation of the MAPK pathway

Combination Therapy with TCM Preparation Kumu Injection and Azithromycin against Bacterial Infection and Inflammation: In Vitro and In Vivo

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