MAPK pathway mediates the anti‑oxidative effect of chicoric acid against cerebral ischemia‑reperfusion injury inï¿½vivo

Jia, Linwei; Chen, Yonghan; Tian, Yaohui; Zhang, Gang

doi:10.3892/etm.2017.5598

Cited by 14 publications

(9 citation statements)

References 26 publications

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“…These results confirm previous findings on the lack of dandelion negative influences in the applied concentrations. It is important to note that the dosage of dandelion leaf and petal fractions (11.9 ± 0.6 mg daily) in our experiment delivered daily were 4.92 ± 0.06 mg and 2.57 ± 0.12 mg HCAs, respectively, which are comparable to those usually employed in similar studies [33,34]. Moreover, like the previous researchers [22,30], we have also observed changes in the blood plasma lipid profile of the supplemented rats.…”

Section: Discussionsupporting

confidence: 87%

Phenolic Fractions from Dandelion Leaves and Petals as Modulators of the Antioxidant Status and Lipid Profile in an In Vivo Study

et al. 2020

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Alcoholic leaf and petal fractions of Taraxacum officinale (dandelion) were previously demonstrated to exert in vitro antioxidant and antithrombotic activities in blood plasma and platelets. Eight-week-old male Wistar rats (n = 6) were supplemented for four weeks with dandelion fractions (694 mg/kg of diet = 11.9 ± 0.6 mg daily). Dandelion leaf and petal fractions, which delivered daily 4.10 ± 0.05 and 1.41 ± 0.07 mg l-chicoric acid, respectively, were shown to exert antioxidative actions, measured as decreased levels of thiobarbituric acid-reactive substances (TBARS) in the spleen (≈0.8-fold, leaves and petals), brain (0.53-fold, leaves) and thoracic arteries (0.59-fold, petals). Moreover, petal fraction increased thiols in the blood plasma (1.58-fold), while leaf fraction decreased protein carbonylation levels (0.59-fold). Additionally, dandelion leaf fractions modified the lipid profile: decreased triglyceride (0.44-fold), total cholesterol (0.73-fold), lipoprotein combine index (0.32-fold) and the atherogenic index of plasma (0.62-fold). Dandelion fractions showed a beneficial decrease effect in the participation of cyclooxygenase products in the noradrenaline-induced vascular contractions of thoracic arteries. Meanwhile, only the dandelion leaf fraction augmented acetylcholine-induced vasodilation and upregulated K ATP channels. The heart rate and blood pressure were not modified. Dandelion leaf and petal phenolic fractions, enriched with l-chicoric acid, are promising plant materials that may exert in vivo beneficial antioxidant effects.Antioxidants 2020, 9, 131 2 of 13 as thrombosis and atherosclerosis. Thus, preparations exerting both antioxidant and anticoagulant activities based on safe natural substances are continuously sought after for their potentially wide range of health benefits in the prevention and treatment of cardiovascular disorders [1][2][3][4][5][6][7].Nowadays, the dandelion (Taraxacum officinale) herb and root are used as a component of food products, dietary supplements and pharmacological preparations for various ailments (mainly liver, gallbladder and kidney disorders) [8,9]. This is due to a wide range of biological activities, including antihyperglycemic, antioxidant and anti-inflammatory actions demonstrated by dandelion fractions and their constituents, with no reported adverse effects, together with a well-understood chemical composition and a widespread occurrence of the plant throughout the world [10,11]. Aqueous-organic extracts from the dandelion herb were found to exert an anti-inflammatory action [12], mainly due to decreasing the expression of proinflammatory cytokines by inhibiting the nuclear factor (NF)-κB [13], tumor necrosis factor (TNF)-α and interleukin (IL)-1β [14], as well as reducing the expression and production of inducible nitric oxide synthase/nitric oxide (iNOS/NO) and cyclooxygenase (COX)-2/prostaglandin E2 [15].Plant polyphenols have the ability to protect dietary lipids, proteins and vitamins from oxidation. Additionally, they may also provide health bene...

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Section: Discussionsupporting

confidence: 87%

Phenolic Fractions from Dandelion Leaves and Petals as Modulators of the Antioxidant Status and Lipid Profile in an In Vivo Study

et al. 2020

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“…In this context, p38 MAPK is of special importance. Apart from playing a crucial role in the monocyte differentiation and chemotaxis 49 , it substantially reduces the ROS mediated brain damage by enhancing the expression of SOD and catalase 50 . It is also implicated in the survival of endothelial cells in cerebral ischemia 51 .…”

Section: Discussionmentioning

confidence: 99%

Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages

Sharmin

Abir

Potol

et al. 2020

Sci Rep

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after MCAO (Fig. 7B and Supplementary Fig. 1B) although the pAkt concentration was unaffected 48 h after the MCAO. Therefore, we conclude that activation of GPR35 on monocyte/macrophages by its ligand pamoic acid reprograms these cell types into neuroprotective pathways. Method Mice. Male Swiss albino mice (8-12 weeks) were collected from the North South University (NSU) animal house and were maintained under standard environmental conditions (temperature 23.0 ± 2.0 °C, relative humidity: 55-65% and 12 h light and dark cycle). All experiments were carried out according to the institutional guideline and were approved by the NSU Institutional Animal Care and Use Committee (IACUC).

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“…Unfortunately, the reperfusion usually evokes cerebral I/R injury, which is the most challenging complication for dealing with ischemic stroke. 7 - 11 Ischemia/reperfusion causes the damage of blood–brain barrier (BBB) and neurons and releases various ions, chemicals, growth factors, and neurotransmitters, which further affect the BBB permeability and aggravate the neuronal damage during cerebra ischemia. 3 , 12 , 13 Among the efforts that have been made to attenuate the I/R injury, numerous types of pretreatment measurements have been suggested by accumulating studies.…”

Section: Introductionmentioning

confidence: 99%

Rapamycin Pretreatment Alleviates Cerebral Ischemia/Reperfusion Injury in Dose-Response Manner Through Inhibition of the Autophagy and NFκB Pathways in Rats

Huang

2020

Dose-Response

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Although rapamycin can attenuate cerebral ischemia/reperfusion (I/R) injury, the potential roles of rapamycin on cerebral I/R injury remain largely controversial. The present work aims to evaluate underlying molecular mechanisms of rapamycin pretreatment on I/R injury. In total, 34 Sprague-Dawley rats were randomly grouped to 3 groups: sham group (n = 2), vehicle group (n = 16), and rapamycin-pretreatment group (n = 16). Before the focal cerebral ischemia was induced, those rats in the pretreatment group were intraperitoneally injected rapamycin (1 mg/kg body) for 20 hours, while rats in the vehicle group received same-volume saline. Then, rats in these 2 groups received focal cerebral ischemia for 3 and 6 hours, respectively (n = 8 in each group), which was followed by the application of reperfusion for 4, 24, 72 hours, and 1 week (n = 2 in each group). The results showed that the rapamycin pretreatment improved the memory functions of rats after I/R injury, which was evaluated using a Y-maze test. Rapamycin pretreatment significantly reduced the size of triphenyltetrazolium chloride infarction and decreased the expression of I/R injury markers. Moreover, the expression of LC-3 and NFκB was also significantly reduced after rapamycin pretreatment. Taken together, rapamycin pretreatment may alleviate cerebral I/R injury partly through inhibiting autophagic activities and NFκB pathways in rats.

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MAPK pathway mediates the anti‑oxidative effect of chicoric acid against cerebral ischemia‑reperfusion injury inï¿½vivo

Cited by 14 publications

References 26 publications

Phenolic Fractions from Dandelion Leaves and Petals as Modulators of the Antioxidant Status and Lipid Profile in an In Vivo Study

Phenolic Fractions from Dandelion Leaves and Petals as Modulators of the Antioxidant Status and Lipid Profile in an In Vivo Study

Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages

Rapamycin Pretreatment Alleviates Cerebral Ischemia/Reperfusion Injury in Dose-Response Manner Through Inhibition of the Autophagy and NFκB Pathways in Rats

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