MAPK pathway and SIRT1 are involved in the down-regulation of secreted osteopontin expression by genistein in metastatic cancer cells

Khongsti, Kitboklang; Das, Kuheli B.; Das, Bidyadhar

doi:10.1016/j.lfs.2020.118787

Cited by 10 publications

(8 citation statements)

References 69 publications

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“…Genistein (4′,5,7-Trihydroxyisoflavone), 5,7-Dihydroxy-3-(4-hydroxyphenyl))-4 H -1-benzopyran-4-one is a natural isoflavone that has been isolated from soybeans and is known as an antimetastatic agent. It inhibited tumor growth and metastasis in vivo and exhibited significant antiproliferative activity on several cancer cells in vitro [ 126 , 127 , 128 ]. Case-control studies showed that dietary soybean intake may reduce one’s cancer risk [ 129 , 130 ].…”

Section: Dietary Phenolic Compounds As Anticancer Drugs: Clinical Trialsmentioning

confidence: 99%

Dietary Phenolic Compounds as Anticancer Natural Drugs: Recent Update on Molecular Mechanisms and Clinical Trials

Bakrim

Omari

Bakri

et al. 2022

Foods

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Given the stochastic complexity of cancer diseases, the development of chemotherapeutic drugs is almost limited by problems of selectivity and side effects. Furthermore, an increasing number of protective approaches have been recently considered as the main way to limit these pathologies. Natural bioactive compounds, and particularly dietary phenolic compounds, showed major protective and therapeutic effects against different types of human cancers. Indeed, phenolic substances have functional groups that allow them to exert several anti-cancer mechanisms, such as the induction of apoptosis, autophagy, cell cycle arrest at different stages, and the inhibition of telomerase. In addition, in vivo studies show that these phenolic compounds also have anti-angiogenic effects via the inhibition of invasion and angiogenesis. Moreover, clinical studies have already highlighted certain phenolic compounds producing clinical effects alone, or in combination with drugs used in chemotherapy. In the present work, we present a major advance in research concerning the mechanisms of action of the different phenolic compounds that are contained in food medicinal plants, as well as evidence from the clinical trials that focus on them.

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Section: Dietary Phenolic Compounds As Anticancer Drugs: Clinical Trialsmentioning

confidence: 99%

Dietary Phenolic Compounds as Anticancer Natural Drugs: Recent Update on Molecular Mechanisms and Clinical Trials

Bakrim

Omari

Bakri

et al. 2022

Foods

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“…Tetramethylpyrazine (TMP, aka ligustrazine, Figure b) is an API isolated from the traditional Chinese herbal medicine, Ligusticum chuanxiong Hort (aka Chuan Xiong) . TMP has been reported to exhibit a wide range of pharmacological activities, such as anti-inflammatory, antithrombosis, antitumor, neuroprotective, , suppression of lipid accumulation, expansion of blood vessels, , and cardiomyocytes protection properties . However, the high sublimation propensity of TMP under ambient condition , affects its manufacturing and clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Drug–Drug Cocrystallization Simultaneously Improves Pharmaceutical Properties of Genistein and Ligustrazine

Liu

Song

et al. 2021

Crystal Growth & Design

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The oral delivery of genistein (GEN) is hindered by its low bioavailability. The delivery of tetramethylpyrazine (TMP or ligustrazine) is faced with physical instability challenges due to its high sublimation tendency. We tackled respective challenges of the two drugs by forming a cocrystal. The GEN-TMP cocrystal exhibits a significantly reduced sublimation tendency than TMP and a significant enhancement in both the in vitro release rate and bioavailability in rats than GEN. Thus, cocrystallization simultaneously improves pharmaceutical properties of both parent drugs.

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“…It has a broad range of anti-cancer properties. Genistein has been analyzed and reviewed in a number of papers for its anti-cancer effects [ 3 , 4 ]. However, in this review we have focused on the genistein mediated modulation of signaling cascades in various types of cancer.…”

Section: Introductionmentioning

confidence: 99%

“…Further, genistein treatment also enhanced SIRT1 expression in schistosomiasis-induced hepatic fibrosis that led to protective effect via α-SMA and TGF-β expression down-regulation [ 23 ]. Genistein-induced SIRT1 expression also down regulates osteopontin expression [ 3 ]. However, no study has been performed so far to investigate the role of genistein on regulators of mTOR and Nrf2 pathways in different types of cancer.…”

Section: Introductionmentioning

confidence: 99%

Genistein as a regulator of signaling pathways and microRNAs in different types of cancers

et al. 2021

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Cancers are complex diseases orchestrated by a plethora of extrinsic and intrinsic factors. Research spanning over several decades has provided better understanding of complex molecular interactions responsible for the multifaceted nature of cancer. Recent advances in the field of next generation sequencing and functional genomics have brought us closer towards unravelling the complexities of tumor microenvironment (tumor heterogeneity) and deregulated signaling cascades responsible for proliferation and survival of tumor cells. Phytochemicals have begun to emerge as potent beneficial substances aimed to target deregulated signaling pathways. Isoflavonoid genistein is an essential phytochemical involved in regulation of key biological processes including those in different types of cancer. Emerging preclinical evidence have shown its anti-cancer, anti-inflammatory and anti-oxidant properties. Testing of this substance is in various phases of clinical trials. Comprehensive preclinical and clinical trials data is providing insight on genistein as a modulator of various signaling pathways both at transcription and translation levels. In this review we have explained the mechanistic regulation of several key cellular pathways by genistein. We have also addressed in detail various microRNAs regulated by genistein in different types of cancer. Moreover, application of nano-formulations to increase the efficiency of genistein is also discussed. Understanding the pleiotropic potential of genistein to regulate key cellular pathways and development of efficient drug delivery system will bring us a step towards designing better chemotherapeutics.

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MAPK pathway and SIRT1 are involved in the down-regulation of secreted osteopontin expression by genistein in metastatic cancer cells

Cited by 10 publications

References 69 publications

Dietary Phenolic Compounds as Anticancer Natural Drugs: Recent Update on Molecular Mechanisms and Clinical Trials

Dietary Phenolic Compounds as Anticancer Natural Drugs: Recent Update on Molecular Mechanisms and Clinical Trials

Drug–Drug Cocrystallization Simultaneously Improves Pharmaceutical Properties of Genistein and Ligustrazine

Genistein as a regulator of signaling pathways and microRNAs in different types of cancers

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