MAPK activation is necessary to the apoptotic death of KB cells induced by the essential oil isolated from Artemisia iwayomogi

Chemical composition and antiproliferative activity of essential oil from aerial parts of a medicinal herb Artemisia herba-alba

“…The anti cancer cytotoxic effect of Artemisia herba-alba essential oil is also demonstrated by the present study. These findings are confirmed by the results of other authors with the essential oil of Artemisia annua L. witch could induce apoptosis of cultured SMMC-7721 hepatocarcinoma cell line (Li et al, 2004), and with the essential oil of Artemisia iwayomogi (Cha et al,2009). The results on cytotoxic assays against cancer using the human oral epidermoid carcinoma cell line, KB cells, strongly suggest that essential oil from Artemisia iwayomogi have cancer chemo-preventive and therapeutic potential.…”

“…The results on cytotoxic assays against cancer using the human oral epidermoid carcinoma cell line, KB cells, strongly suggest that essential oil from Artemisia iwayomogi have cancer chemo-preventive and therapeutic potential. This activity is closely related to the ability of the essential oil to induce apoptosis and to activate the MAPK-mediated signaling pathways with the subsequent induction of a mitochondria-and caspase-dependent mechanism (Cha et al, 2009). The molecular mechanisms involved in the antitumor activity induced by essential oil of Moroccan A. herbaalba which showed a differential chemical composition needs to be investigated.…”

Acanthoic acid induces cell apoptosis through activation of the p38 MAPK pathway in HL-60 human promyelocytic leukaemia

“…MAPKs, including JNK, ERK, and p38 kinase, are activated by various extracellular stimuli and mediate the signal transduction cascades that play an important role in regulating apoptosis (Ahmed-Choudhury et al, 2006;Cha et al, 2009). Therefore, we measured the phosphorylation levels of these MAPKs by western blotting.…”

“…Because it was recently suggested that cancer chemotherapeutics exert some of their pharmacological effects by triggering apoptotic cell death, the induction of apoptosis in cancer cells has become a strategy for cancer treatment (Ahmad, Feyes, Nieminen, Agarwal, & Mukhtar, 1997;Fulda & Debatin, 2006;Kim, Heo, Kang, Ahn, & Jeon, 2010). Several signalling pathways, such as the caspase, mitochondrial, and mitogen-activated protein kinase (MAPK) pathways, tightly regulate the apoptotic process (Ahmed-Choudhury, Williams, Young, Adams, & Afford, 2006;Cha, Jeong, Kim, Lee, & Lee, 2009). A significant physiological consequence of cell death by apoptosis is the immediate phagocytosis of the apoptotic cells by macrophages, which occurs in the absence of secondary tissue disturbance or inflammation (Ahmed-Choudhury et al, 2006;Cha et al, 2009).…”

“…Several signalling pathways, such as the caspase, mitochondrial, and mitogen-activated protein kinase (MAPK) pathways, tightly regulate the apoptotic process (Ahmed-Choudhury, Williams, Young, Adams, & Afford, 2006;Cha, Jeong, Kim, Lee, & Lee, 2009). A significant physiological consequence of cell death by apoptosis is the immediate phagocytosis of the apoptotic cells by macrophages, which occurs in the absence of secondary tissue disturbance or inflammation (Ahmed-Choudhury et al, 2006;Cha et al, 2009). Therefore, the induction of apoptosis in cancer cells is considered to indicate the anti-tumour activity of naturally derived components (Sun & Peng, 2009;Tan, Ooi, Ismail, Moad, & Muhammad, 2009;Ward et al, 2008;Yang, Sales, Fuller, Seifalian, & Winslet, 2009).…”