Mapeo de los cambios de grosor en el glaucoma de las capas retinianas maculares segmentadas usando el programa de polo posterior de la tomografía de coherencia óptica de dominio espectral

García-Medina, J.J.; del-Río-Vellosillo, Mónica; Palazón-Cabanes, Ana; Tudela-Molino, M.; Gómez-Molina, C.; Guardiola-Fernández, A.; Villegas–Pérez, M.P.

doi:10.1016/j.oftal.2018.01.010

Cited by 4 publications

(6 citation statements)

References 24 publications

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“…Glaucoma is a chronic and progressive neuropathy of the optic nerve characterized by retinal ganglion cell apoptosis [ 1 ]. This event is not only associated with optic nerve cupping due to retinal nerve fiber layer loss (dendrites of the retinal ganglion cells) but also with changes at different intraretinal layers of the macula as shown in our previous studies [ 2 , 3 ].…”

Section: Introductionsupporting

confidence: 58%

“…However, not only inner retinal layers are affected in glaucoma. Experimental studies [ 15 , 16 ] and human studies [ 2 , 3 ] have shown that outer retinal layers are also altered in glaucoma. However, to the best of our knowledge, the structure–function relationship for outer retinal layers has not been previously studied with MP.…”

Section: Discussionmentioning

confidence: 99%

“…Although glaucoma is primarily a disease of ganglion cells, in the light perception and early integration of visual stimuli all retinal layers participate, not only in inner retinal layers. Considering the structural changes detected by our group in glaucoma [ 2 , 3 ], we hypothesize that there could exist associations between thickness of all retinal layers with its anatomically corresponding sensitivity in glaucoma and, specifically, with such a precise technology as MP. To the best of our knowledge, we have not found any study in this sense.…”

Section: Introductionmentioning

confidence: 99%

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Macular Structure–Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 × 8 Posterior Pole Analysis of OCT

García-Medina

Rotolo

Rubio-Velázquez

et al. 2021

JCM

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Purpose: The aim of this study is too correlate the sensitivity and thickness values of intraretinal layers at macula in healthy eyes and primary open-angle glaucoma (POAG) eyes. Methods: The thickness of different intraretinal segmentations was estimated by means of optical coherence tomography (OCT) Spectralis (Heidelberg, Engineering, Inc., Heidelberg, Germany) with the posterior pole analysis program 8 × 8 in 91 eyes from 91 patients (60 with glaucoma and 31 healthy patients). Macular sensitivity was also measured with an MP-1 microperimeter (Nidek Instruments, Inc Padova, Italy) with a customized, 36-stimulus pattern adjusted to an anatomical correspondence with the OCT grid. Correlations were calculated by using Spearman’s rho and the results were represented in color maps. Results: Significant structure–function correlations were much more frequent in the glaucoma group than in control group. In general terms, associations were positive for inner retinal layers but negative correlations were also found for the inner nuclear layer and outer retinal layer in glaucoma. Conclusions: In general terms, significant structure–function correlations for different intraretinal layers are higher and wider in POAG eyes than in healthy eyes. Inner and outer retinal layers behave differently in terms of the structure–function relationship in POAG as assessed by microperimetry and OCT.

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Section: Introductionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Macular Structure–Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 × 8 Posterior Pole Analysis of OCT

García-Medina

Rotolo

Rubio-Velázquez

et al. 2021

JCM

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“…In the present study, we created a normative database for the 8 × 8 PPA of Spectralis SD-OCT because this protocol lacks a normative database and, thus, does not allow results to be compared. This is the first step to try to define specific patterns of thickness change in macular segmentations on 8 × 8 PPA in different ocular and non-ocular diseases such as glaucoma [ 4 , 7 ], and at different stages of the considered disorder.…”

Section: Discussionmentioning

confidence: 99%

“…Many ocular diseases tend to affect the macula. These diseases are usually degenerative diseases that cause neuronal loss and, thus, produce the thickness of the total macula and cause different macular layers to thin [ 3 , 4 , 5 ]. However, some other diseases also produce increased thickness of macular layers [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Normative Database for All Retinal Layer Thicknesses Using SD-OCT Posterior Pole Algorithm and the Effects of Age, Gender and Axial Lenght

Palazón-Cabanes

Rubio-Velázquez

et al. 2020

JCM

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Our aim was to provide, for the first time, reference thickness values for the SD-OCT posterior pole algorithm (PPA) available for Spectralis OCT device (Heidelberg Engineering, Heidelberg, Germany) and to analyze the correlations with age, gender and axial length. We recruited 300 eyes of 300 healthy Caucasian subjects between 18 and 84 years. By PPA, composed of 64 (8 × 8) cells, we analyzed the thickness of the following macular layers: retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE), inner retina, outer retina and full retina. Mean ± SD, 1st, 5th, 95th percentiles were obtained for each cell at all macular layers. Significant negative correlations were found between age and thickness for most macular layers. The mean thickness of most macular layers was thicker for men than women, except for RNFL, OPL and RPE, with no gender differences. GCL, IPL and INL thicknesses positively correlated with axial length in central cells, and negatively in the cells near the optic disk. The mean RNFL thickness was positively associated with axial length. This is the first normative database for PPA. Age, gender and axial length should be taken into account when interpreting PPA results.

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The thickness of the outer retina in the macula and circumpapillary area in patients with unilateral advanced glaucoma

Vahedian

Fakhraie

Ghasemi

et al. 2022

Graefes Arch Clin Exp Ophthalmol

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Mapeo de los cambios de grosor en el glaucoma de las capas retinianas maculares segmentadas usando el programa de polo posterior de la tomografía de coherencia óptica de dominio espectral

Cited by 4 publications

References 24 publications

Macular Structure–Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 × 8 Posterior Pole Analysis of OCT

Macular Structure–Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 × 8 Posterior Pole Analysis of OCT

Normative Database for All Retinal Layer Thicknesses Using SD-OCT Posterior Pole Algorithm and the Effects of Age, Gender and Axial Lenght

The thickness of the outer retina in the macula and circumpapillary area in patients with unilateral advanced glaucoma

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