MAP kinase signalling cascades and transcriptional regulation

Yang, Shen Hsi; Sharrocks, Andrew D.; Whitmarsh, Alan J.

doi:10.1016/j.gene.2012.10.033

Cited by 377 publications

(293 citation statements)

References 154 publications

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“…The MAPK family has been classified into 3 distinct subfamilies: the extracellular signal-regulated protein kinases (ERKs) including ERK1/2, the stress-activated c-Jun N-terminal protein kinase (JNKs) and p38 kinase (Hoshino et al, 1999;Doddareddy et al, 2012). The MAP kinase cascade and PI3K/Akt are all effectors of Ras signaling (Downward, 2003;McCubrey et al, 2012), which have been implicated in a wide range of cellular functions, including proliferation, survival, migration, malignant transformation (Wee et al, 2008;Yang et al, 2013), and also in the development of drug resistance (Navolanic et al, 2003;Sui et al, 2012). In our study, we found that JNK and ERK1/2 were activated in A2780/ Taxol cells.…”

Section: Discussionmentioning

confidence: 99%

Mechanistic Analysis of Taxol-induced Multidrug Resistance in an Ovarian Cancer Cell Line

Wang¹,

Zhao²,

Wu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Mechanistic Analysis of Taxol-induced Multidrug Resistance in an Ovarian Cancer Cell Line

Wang¹,

Zhao²,

Wu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…These sub-pathways correspond to the ERK1/2, JNK1/2/3, p38α/β/γ/δ and ERK5 subfamilies of MAPK, respectively, and are a chain of proteins that transduce various extracellular signals to the nucleus, controlling gene expression through transcriptional factors (14). By regulating protein activities through signaling cascades that consist of MAPK kinase kinase (MAPKKK), MAPK kinase and MAPK (15), these sub-pathways impact tumor cell proliferation, differentiation and survival (16,17), as presented in Fig.…”

Section: Mapk Signaling Sub-pathwaysmentioning

confidence: 99%

Mitogen-activated protein kinase signaling pathway in oral cancer (Review)

et al. 2017

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Abstract. The mitogen-activated protein kinase (MAPK) signaling pathway is associated with tumor cell proliferation, differentiation, apoptosis, angiogenesis, invasion and metastasis. The present review assesses the involvement of the MAPK signaling pathway in oral cancer progression and invasion based on analysis of individual sub-pathways and their mechanisms of action. The regulation of this pathway for targeted oral cancer therapy is explored and the challenges confronting this, as well as corresponding potential solutions, are discussed. Exploring this pathway with an emphasis on its components, subfamilies, sub-pathways, interactions with other pathways and clinical practice modes may improve oral cancer treatment.

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“…ERK, which is the terminal kinase in the threelayered MAPK/ERK cascade, phosphorylates multiple signaling molecules and transcription factors (Yoon and Seger 2006;von Kriegsheim et al 2009;Yang et al 2013). An example of ERKmediated negative feedback is the phosphorylation of the guanine nucleotide exchange factor SOS.…”

Section: Positive and Negative Feedbacks At The Signaling Levelmentioning

confidence: 99%

Complexity of Receptor Tyrosine Kinase Signal Processing

Volinsky

Kholodenko

2013

Cold Spring Harbor Perspectives in Biology

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Our knowledge of molecular mechanisms of receptor tyrosine kinase (RTK) signaling advances with ever-increasing pace. Yet our understanding of how the spatiotemporal dynamics of RTK signaling control specific cellular outcomes has lagged behind. Systems-centered experimental and computational approaches can help reveal how overlapping networks of signal transducers downstream of RTKs orchestrate specific cell-fate decisions. We discuss how RTK network regulatory structures, which involve the immediate posttranslational and delayed transcriptional controls by multiple feed forward and feedback loops together with pathway cross talk, adapt cells to the combinatorial variety of external cues and conditions. This intricate network circuitry endows cells with emerging capabilities for RTK signal processing and decoding. We illustrate how mathematical modeling facilitates our understanding of RTK network behaviors by unraveling specific systems properties, including bistability, oscillations, excitable responses, and generation of intricate landscapes of signaling activities.

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MAP kinase signalling cascades and transcriptional regulation

Cited by 377 publications

References 154 publications

Mechanistic Analysis of Taxol-induced Multidrug Resistance in an Ovarian Cancer Cell Line

Mechanistic Analysis of Taxol-induced Multidrug Resistance in an Ovarian Cancer Cell Line

Mitogen-activated protein kinase signaling pathway in oral cancer (Review)

Complexity of Receptor Tyrosine Kinase Signal Processing

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