MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1–cMET signaling

Liu, Yin; Li, Jingjing; Wang, Jing; Pu, Tianjie; Wei, Jing; Li, Qinlong; Wu, Bainan

doi:10.1038/s41388-020-01615-2

Cited by 55 publications

(42 citation statements)

References 47 publications

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“…In addition, recent study also showed that gene upregulation specific for embryonic melanoblasts is necessary to facilitate melanoma dissemination ( 41 ). The results of a previous study demonstrated that PLXNA2 played a key role in the regulation of perineural invasion of prostate cancer ( 42 ). Moreover, Tivan TV et al.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic Profiling Revealed Plexin A2 Downregulation With Migration and Invasion Alteration in Dacarbazine-Treated Primary Melanoma Cells

et al. 2021

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Melanoma is highly heterogeneous type of malignant neoplasm that is responsible for the majority of deaths among other types of skin cancer. In the present study, we screened a list of differentially expressed genes in two primary, drug-naïve melanoma cell lines derived from patients with melanoma following treatment of the cells with the chemotherapeutic agent dacarbazine. The aim was to determine the transcriptomic profiles and associated alterations in the cell phenotype. We found the vascular endothelial growth factor A/vascular endothelial growth factor receptor 2, phosphoinositide 3-kinase/protein kinase B and focal adhesion signaling pathways to be top altered after dacarbazine treatment. In addition, we observed the expression levels of genes associated with tumor dissemination, integrin β8 and matrix metalloproteinase-1, to be diminished in both cell lines studied, the results of which were confirmed by reverse transcription-quantitative polymerase chain reaction. By contrast, plexin A2 expression was found to be upregulated in K2303 cells, where reduced migration and invasion were also observed, following dacarbazine treatment. Plexin A2 downregulation was associated with the promotion of migrative and invasive capacities in B0404 melanoma cells. Since plexin A2 is semaphorin co-receptor that is involved in focal adhesion and cell migration regulation, the present study suggested that plexin A2 may be implicated in the dacarbazine-mediated phenotypic shift of melanoma cells. We propose that the signature of cancer cell invasiveness can be revealed by using a combination of transcriptomic and functional approaches, which should be applied in the development of personalized therapeutic strategies for each patient with melanoma.

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Section: Discussionmentioning

confidence: 99%

Transcriptomic Profiling Revealed Plexin A2 Downregulation With Migration and Invasion Alteration in Dacarbazine-Treated Primary Melanoma Cells

et al. 2021

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“…MARCH4 is a E3 ubiquitin-protein ligase that is predicted to mediate ubiquitination of MHC-I and CD4 and promote their subsequent endocytosis and sorting to lysosomes through multivesicular bodies [ 41 ]. CDCA7L plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter and is involved in apoptotic signaling pathways [ 42 , 43 ]. TMEM117 is involved in ER stress-induced cell death pathway [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Molecular cloning, characterization, and functional analysis of the uncharacterized C11orf96 gene

et al. 2022

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Background The mammalian genome encodes millions of proteins. Although many proteins have been discovered and identified, a large part of proteins encoded by genes are yet to be discovered or fully characterized. In the present study, we successfully identified a host protein C11orf96 that was significantly upregulated after viral infection. Results First, we successfully cloned the coding sequence (CDS) region of the cat, human, and mouse C11orf96 gene. The CDS region of the C11orf96 gene is 372 bp long, encodes 124 amino acids, and is relatively conserved in different mammals. From bioinformatics analysis, we found that C11orf96 is rich in Ser and has multiple predicted phosphorylation sites. Moreover, protein interaction prediction analysis revealed that the protein is associated with several transmembrane family proteins and zinc finger proteins. Subsequently, we found that C11orf96 is strictly distributed in the cytoplasm. According to the tissue distribution characteristics, C11orf96 is distributed in all tissues and organs, with the highest expression levels in the kidney. These results indicate that C11orf96 may play a specific biological role in the kidney. Conclusions Summarizing, these data lay the foundation for studying the biological functions of C11orf96 and for exploring its role in viral replication.

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“…The density of infiltrated nerves is positively associated with tumor metastasis, morbidity, and mortality, and has been shown to be an independent risk factor for survival prognosis in a variety of cancers, including PC [ 7 – 10 ], gastric cancer(GC) [ 11 , 12 ], biliary tract cancer [ 13 ], head and neck cancer [ 14 – 16 ], and cervical cancer [ 17 , 18 ]. In PRC [ 19 , 20 ], PC [ 21 ], GC [ 22 ], and CRC [ 23 – 26 ], the density of infiltrated nerves is a factor that relates to recurrence risk. Furthermore, innervation of cancers may play an important direct role in promoting metastasis, as cancer-associated nerves may extend into the central nervous system and activate the precursors of metastasis [ 23 , 27 ].…”

Section: Nerves Step Into Our Viewmentioning

confidence: 99%

Targeting tumor innervation: premises, promises, and challenges

Peng

Yang

et al. 2022

Cell Death Discov.

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A high intratumoral nerve density is correlated with poor survival, high metastasis, and high recurrence across multiple solid tumor types. Recent research has revealed that cancer cells release diverse neurotrophic factors and exosomes to promote tumor innervation, in addition, infiltrating nerves can also mediate multiple tumor biological processes via exosomes and neurotransmitters. In this review, through seminal studies establishing tumor innervation, we discuss the communication between peripheral nerves and tumor cells in the tumor microenvironment (TME), and revealed the nerve-tumor regulation mechanisms on oncogenic process, angiogenesis, lymphangiogenesis, and immunity. Finally, we discussed the promising directions of ‘old drugs newly used’ to target TME communication and clarified a new line to prevent tumor malignant capacity.

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MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1–cMET signaling

Cited by 55 publications

References 47 publications

Transcriptomic Profiling Revealed Plexin A2 Downregulation With Migration and Invasion Alteration in Dacarbazine-Treated Primary Melanoma Cells

Transcriptomic Profiling Revealed Plexin A2 Downregulation With Migration and Invasion Alteration in Dacarbazine-Treated Primary Melanoma Cells

Molecular cloning, characterization, and functional analysis of the uncharacterized C11orf96 gene

Targeting tumor innervation: premises, promises, and challenges

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