MAOA, MTHFR, and TNF-β genes polymorphisms and personality traits in the pathogenesis of migraine

Abstract

Migraine is a multifactorial disease with various factors, such as genetic polymorphisms and personality traits, but the contribution of those factors is not clear. To clarify the pathogenesis of migraine, the contributions of genetic polymorphisms and personality traits were simultaneously investigated using multivariate analysis. Ninety-one migraine patients and 119 non-headache healthy volunteers were enrolled. The 12 gene polymorphisms analysis and NEO-FFI personality test were performed. At first, the univariate analysis was performed to extract the contributing factors to pathogenesis of migraine. We then extracted the factors that independently contributed to the pathogenesis of migraine using multivariate stepwise logistic regression analysis. Using the multivariate analysis, three gene polymorphisms including monoamine oxidase A (MAOA) T941G, methylenetetrahydrofolate reductase (MTHFR) C677T, and tumor necrosis factor beta (TNF-β) G252Α, and the neuroticism and conscientiousness scores in NEO-FFI were selected as significant factors that independently contributed to the pathogenesis of migraine. Their odds ratios were 1.099 (per point of neuroticism score), 1.080 (per point of conscientiousness score), 2.272 (T and T/T or T/G vs G and G/G genotype of MAOA), 1.939 (C/T or T/T vs C/C genotype of MTHFR), and 2.748 (G/A or A/A vs G/G genotype of TNF-β), respectively. We suggested that multiple factors, such as gene polymorphisms and personality traits, contribute to the pathogenesis of migraine. The contribution of polymorphisms, such as MAOA T941G, MTHFR C677T, and TNF-β G252A, were more important than personality traits in the pathogenesis of migraine, a multifactorial disorder.

Association Analysis of the Functional MAOA Gene Promoter and MAOB Gene Intron 13 Polymorphisms in Tension Type Headache Patients

“…In a study by Filic V et al, no association was detected in migraine patients with and without aura [22]. Another study revealed that plasma 5-HT levels in migraine patients without aura are lower when compared to controls, based on the higher G allele and G/G genotype of T941G polymorphisms of MAOA in migraine patients [25]. Our results failed to show a relationship between MAO enzymes gene polymorphisms and TTH.…”

Influence of the Tohoku-Pacific Ocean Earthquake and Its Aftershocks on the Response to Prophylactic Therapy with Lomerizine in Patients with Migraine in Tokyo: A Retrospective Study

“…Migraine [5,28] and depression [29,30] are known to be associated with high neuroticism. Kanki et al [31] reported that the comorbidity with depression is observed in 12.9% of the patients with migraine.…”

“…Migraines are usually characterized by severe pain on one or both sides of the head and at times disturbed vision [3,4,5]. Migraine is a multifactorial disease, and gene polymorphisms and personality traits both contribute to its pathogenesis [5].…”

“…Migraine is a multifactorial disease, and gene polymorphisms and personality traits both contribute to its pathogenesis [5]. Stress induced by the events of daily life is considered a major factor contributing to the onset of migraine [6].…”

Effects of Tumor Necrosis Factor-β (TNF-β) 252A>G Polymorphism on the Development of Migraine: A Meta-Analysis

“…Since then, several follow-up studies have been continuously carried out in an effort to replicate the initial finding. Some were successful [16], [17], whereas others failed [18], [19]. Multiple factors including selection of diverse populations, different control sources, and misclassification of genotypes may individually or jointly result in the controversy, but the main source can attribute to the various numbers of subjects used in each study.…”