Many XCI-ting routes to reach the eXACT dose

Ouimette, Jean-François; Rougeulle, Claire

doi:10.1038/s41556-020-00608-3

Cited by 2 publications

(1 citation statement)

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“…An alternative hypothesis for reduced X-linked gene dosage in female germ cells could be incomplete XCR, as it has been previously proposed [ 147 ]. From the currently available data, many different possible interpretations for X-linked gene dosage regulation in human germ cells exist; ranging from the possibility of continuous dampening in the absence of XCI and XCR, over XCI and XCU followed by XCR, to a sequence of all XCI, XCU, XCR and dampening [ 103 , 151 ]. Needless to say, further investigations including allele-specific single-cell RNA-Seq and multi-omics analyses will be necessary to bring clarity to the complex control of X-linked gene dosage during human germ cell development in vivo .…”

Section: X-chromosome Dynamics In the Primate Germlinementioning

confidence: 99%

The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development

Mattimoe

Payer

2023

Biochemical Journal

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In female mammals, the two X chromosomes are subject to epigenetic gene regulation in order to balance X-linked gene dosage with autosomes and in relation to males, which have one X and one Y chromosome. This is achieved by an intricate interplay of several processes; X-chromosome inactivation and reactivation elicit global epigenetic regulation of expression from one X chromosome in a stage-specific manner, whilst the process of X-chromosome upregulation responds to this by fine-tuning transcription levels of the second X. The germline is unique in its function of transmitting both the genetic and epigenetic information from one generation to the next, and remodelling of the X chromosome is one of the key steps in setting the stage for successful development. Here, we provide an overview of the complex dynamics of X-chromosome dosage control during embryonic and germ cell development, and aim to decipher its potential role for normal germline competency.

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Section: X-chromosome Dynamics In the Primate Germlinementioning

confidence: 99%