Many roles for Pax7

Dulak, Józef

doi:10.1080/15384101.2016.1248729

Cited by 6 publications

(7 citation statements)

References 7 publications

(9 reference statements)

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“…Most of these genes have been shown to be related to the tumorigenesis and metastasis of various cancers in previous studies as described below. PAX7 is a member of the pairedbox (PAX) family of TFs, which contains a PAX domain that plays vital roles in postnatal skeletal muscle development, fetal development, and cancer growth (28). The function of PAX7 is context and tumor-specific.…”

Section: Discussionmentioning

confidence: 99%

Identification and validation of a novel prognostic signature based on transcription factors in breast cancer by bioinformatics analysis

Yang¹,

Li²,

Zhao³

et al. 2022

Gland Surg

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Background: Breast cancer (BRCA) is the leading cause of cancer mortality among women, and it is associated with many tumor suppressors and oncogenes. There is increasing evidence that transcription factors (TFs) play vital roles in human malignancies, but TFs-based biomarkers for BRCA prognosis were still rare and necessary. This study sought to develop and validate a prognostic model based on TFs for BRCA patients.Methods: Differentially expressed TFs were screened from 1,109 BRCA and 113 non-tumor samples downloaded from The Cancer Genome Atlas (TCGA). Univariate Cox regression analysis was used to identify TFs associated with overall survival (OS) of BRCA, and multivariate Cox regression analysis was performed to establish the optimal risk model. The predictive value of the TF model was established using TCGA database and validated using a Gene Expression Omnibus (GEO) data set (GSE20685). A gene set enrichment analysis was conducted to identify the enriched signaling pathways in high-risk and low-risk BRCA patients. Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of the TF target genes were also conducted separately.

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Section: Discussionmentioning

confidence: 99%

Identification and validation of a novel prognostic signature based on transcription factors in breast cancer by bioinformatics analysis

Yang¹,

Li²,

Zhao³

et al. 2022

Gland Surg

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“…Complete recovery happens in five consecutive steps: necrosis, inflammation, regeneration, maturation and functional recovery. The initial inflammatory phase is characterized by chemotactic recruitment of circulating leukocytes, starting with neutrophil infiltration, followed by two different subpopulations of macrophages invading the injured muscle [2][3][4]. To restore functional muscle fibers, muscle stem cells (MuSCs), also called satellite cells (SCs), are activated upon muscle injury followed by a myogenic differentiation program to fuse and form new myofibers and to restore muscle tissue [5].…”

Section: Introductionmentioning

confidence: 99%

Reduced Expression of Septin7 Hinders Skeletal Muscle Regeneration

Szabó,

Telek,

Fodor

et al. 2023

IJMS

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Septins are considered the fourth component of the cytoskeleton with the septin7 isoform playing a critical role in the formation of diffusion barriers in phospholipid bilayers and intra- and extracellular scaffolds. While its importance has already been confirmed in different intracellular processes, very little is known about its role in skeletal muscle. Muscle regeneration was studied in a Sept7 conditional knock-down mouse model to prove the possible role of septin7 in this process. Sterile inflammation in skeletal muscle was induced which was followed by regeneration resulting in the upregulation of septin7 expression. Partial knock-down of Sept7 resulted in an increased number of inflammatory cells and myofibers containing central nuclei. Taken together, our data suggest that partial knock-down of Sept7 hinders the kinetics of muscle regeneration, indicating its crucial role in skeletal muscle functions.

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“…CD49f was relatively effective for sorting SSCs by MACS, and the goat CD49f‐positive testicular cells were proved to be putative SSCs, which were identified by surface markers, key transcription factor, and microRNA profiles (Wu et al, 2014; Zheng et al, 2016). Pax7 is expressed in stem cells and differentiated cells, playing different functions in different cells (Dulak, 2017). It is required for satellite cells' expansion (von Maltzahn, Jones, Parks, & Rudnicki, 2013; Seale et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

PAX7 promotes CD49f‐positive dairy goat spermatogonial stem cells' self‐renewal

Wei

et al. 2020

Journal Cellular Physiology

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Spermatogenesis is a complex process that originates from and depends on the spermatogonial stem cells (SSCs). The number of SSCs is rare, which makes the separation and enrichment of SSCs difficult and inefficient. The transcription factor PAX7 maintains fertility in normal spermatogenesis in mice. However, for large animals, much less is known about the SSCs' self-renewal regulation, especially in dairy goats. We isolated and enriched the CD49f-positive and negative dairy goat testicular cells by magnetic-activated cell sorting strategies. The RNA-sequencing and experimental data revealed that cells with a high CD49f and PAX7 expression are undifferentiated spermatogonia in goat testis. Our findings indicated that ZBTB16 (PLZF), PAX7, LIN28A, BMPR1B, FGFR1, and FOXO1 were expressed higher in CD49f-positive cells as compared to negative cells and goat fibroblasts cells. The expression and distribution of PAX7 in dairy goat also have been detected, which gradually decreased in testis tissue along with the increasing age. When the PAX7 gene was overexpressed in dairy goat immortal mGSCs-I-SB germ cell lines, the expression of PLZF, GFRα1, ID4, and OCT4 was upregulated. Together, our data demonstrated that there is a subset of spermatogonial stem cells with a high expression of PAX7 among the CD49f + spermatogonia, and PAX7 can maintain the selfrenewal of CD49f-positive SSCs.

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Many roles for Pax7

Cited by 6 publications

References 7 publications

Identification and validation of a novel prognostic signature based on transcription factors in breast cancer by bioinformatics analysis

Identification and validation of a novel prognostic signature based on transcription factors in breast cancer by bioinformatics analysis

Reduced Expression of Septin7 Hinders Skeletal Muscle Regeneration

PAX7 promotes CD49f‐positive dairy goat spermatogonial stem cells' self‐renewal

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