“…(29) Auto-PEEP is associated with increased intrathoracic pressure and reduced cerebral venous return, (32) predisposing to intracranial pressure increase in extensive brain injury patients. (27,28) Conti et al, evaluating healthy volunteers that spontaneous breathing, noted that HMEF lead to increased R sr , and that the respiratory muscles workload may be reduced by expiratory time prolongation. (33) In this study we found no clinical signs of increased respiratory work, as all patients were under sedation and/or anesthesia, and controlled ventilation.…”