wine production is a major industry worldwide, contributing to the global economy and food security. In 2017, the United States produced over 72 million swine (USDA-NASS, 2019), resulting in an estimated 100 million Mg of manure (USEPA, 2013). Overall, this manure likely contains more than 0.85 million Mg nitrogen (N), 0.3 million Mg of phosphorus (P), and 0.48 million Mg of potassium (K) (Hatfield et al., 1998). Land application of manure utilizes these nutrients to meet crop demand, reduces the need for supplemental synthetic fertilizer, and removes the need for alternative disposal practices. Swine manure application has the potential to increase crop yields (Wortman et al., 2017; Choudhary et al., 1996) but may also be associated with negative impacts to environmental quality, such as increased nutrient leaching (Choudhary et al., 1996) or increased ammonia emissions (Chantigny et al., 2007). Much of the uncertainty regarding swine manure application as fertilizer comes from divergent findings in the literature. For example, Schlegel et al. (2015) evaluated soil physiochemical properties after 10 yr of swine manure application and found that swine manure did not affect soil P, soil N, soil C, organic matter, or electrical conductivity. However, other evidence suggests that repeated manure applications increases soil nutrients and subsequent risk of losses through leaching, runoff, or gas emission (Ball-Coelho et al., 2004; Shepherd and Newell-Price, 2013). Many of these inconsistencies stem from differences in site-specific characteristics, such as application rates, crop management systems, climate, and soil properties. In these circumstances, meta-analytic techniques may be used to evaluate the results of independent studies while accounting for a wide range of experimental conditions. The objective of this study was to conduct a metaanalysis to compare the effects of swine manure and synthetic fertilizer on both a measure of production, crop yield and a measure of environmental quality, nitrous oxide (N 2 O) emissions.