Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis

Evening primrose seed extract rich in polyphenols modulates the invasiveness of colon cancer cells by regulating the TYMS expression

“…These results are in line with previous observations showing that polyphenol-enriched food such as Manuka honey and strawberry tree honey sensitizes colon cancer cells to 5-FU. [54][55][56] It is also consistent with the general phenomenon showing that natural substances may sensitise tumour cells to conventional chemotherapeutics and reinforce the drug's effective concentration in socalled combination therapy. 57 On the other hand, the EPE has no effect on the sensitisation of 5-FU-resistant colon cancer cells.…”

Amyloid β-but not Tau-induced neurotoxicity is suppressed by Manuka honeyviaHSP-16.2 and SKN-1/Nrf2 pathways in anin vivomodel of Alzheimer's disease

“…Despite the fact that MH is a natural product with remarkable biological properties both in vitro [8][9][10][11][36][37][38] and in vivo, 39,40 little is known about its neuroprotective potential. Considering its ability to scavenge free radicals and the implication of oxidative stress in the pathogenesis of age-related diseases such as AD, we decided to investigate the possible effects of MH in alleviating Aβ and Tau-induced toxicity in C. elegans models of AD.…”

Honey polyphenols: regulators of human microbiota and health

“…Food & Function last decade, linking honey consumption and health, are associated with the potential anticancer 20,21,58,[74][75][76][77][78][79][80] and regenerative [81][82][83][84][85][86] properties of honey.…”