Mānuka honey-derived methylglyoxal enhances microbial sensing by mucosal-associated invariant T cells

Tang, Jeffry S.; Compton, Benjamin J.; Marshall, Andrew J.; Anderson, Regan J.; Li, Yanyan; Woude, Hannah van der; Hermans, Ian F.; Painter, Gavin F.; Gasser, Olivier

doi:10.1039/d0fo01153c

Cited by 12 publications

(7 citation statements)

References 31 publications

(51 reference statements)

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“…Methylglyoxal (MGO) is a 1,2-dicarbonyls-breakdown-product of antimicrobial significance, and it has been identified as the main antibacterial compound in manuka honey [14]. The high levels of MGO found in this variety of honey are formed by the spontaneous dehydration of dihydroxyacetone, which is present at unusually high concentrations in the nectar of Leptospermum genus, including Leptospermum scoparium, Leptospermum polygalifolium, and some related Leptospermum species native to New Zealand and Australia [48][49][50]. Originally, it was assumed that manuka honey was the only variety that presents MGO in its composition.…”

Section: Methylglyoxalmentioning

confidence: 99%

Honey: Another Alternative in the Fight against Antibiotic-Resistant Bacteria?

et al. 2020

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Antibacterial resistance has become a challenging situation worldwide. The increasing emergence of multidrug-resistant pathogens stresses the need for developing alternative or complementary antimicrobial strategies, which has led the scientific community to study substances, formulas or active ingredients used before the antibiotic era. Honey has been traditionally used not only as a food, but also with therapeutic purposes, especially for the topical treatment of chronic-infected wounds. The intrinsic characteristics and the complex composition of honey, in which different substances with antimicrobial properties are included, make it an antimicrobial agent with multiple and different target sites in the fight against bacteria. This, together with the difficulty to develop honey-resistance, indicates that it could become an effective alternative in the treatment of antibiotic-resistant bacteria, against which honey has already shown to be effective. Despite all of these assets, honey possesses some limitations, and has to fulfill a number of requirements in order to be used for medical purposes.

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Section: Methylglyoxalmentioning

confidence: 99%

Honey: Another Alternative in the Fight against Antibiotic-Resistant Bacteria?

et al. 2020

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“…It is known that MAIT cells can effectively regulate a diverse range of immune responses which includes antimicrobial defense as well. In human monolayer cells, MGO has significantly increased MAIT cells in vitro [56].…”

Section: Immune Responses and Inflammationmentioning

confidence: 96%

Prospects of honey in fighting against COVID-19: pharmacological insights and therapeutic promises

Hossain¹,

Hossain

Moni³

et al. 2020

Heliyon

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Honey and its compounds are drawing attention as an effective natural therapy because of its ability to attenuate acute inflammation through enhancing immune response. Several studies have proved its potential healing capability against numerous chronic diseases/conditions, including pulmonary disorders, cardiac disorders, diabetes, hypertension, autophagy dysfunction, bacterial, and fungal infections. More importantly, honey has proved its virucidal effect on several enveloped viruses such as HIV, influenza virus, herpes simplex, and varicella-zoster virus. Honey may be beneficial for patients with COVID-19 which is caused by an enveloped virus SARS-CoV-2 by boosting the host immune system, improving comorbid conditions, and antiviral activities. Moreover, a clinical trial of honey on COVID-19 patients is currently undergoing. In this review, we have tried to summarize the potential benefits of honey and its ingredients in the context of antimicrobial activities, some chronic diseases, and the host immune system. Thus, we have attempted to establish a relationship with honey for the treatment of COVID-19. This review will be helpful to reconsider the insights into the possible potential therapeutic effects of honey in the context of the COVID-19 pandemic. However, the effects of honey on SARS-CoV-2 replication and/or host immune system need to be further investigated by in vitro and in vivo studies.

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“…The formation of methyl glyoxal takes on additional significance with the recent report that Manuka honey-derived methylglyoxal can enhance microbial sensing by mucosal-associated invariant T cells, which are found, for example, in the oral and gastrointestinal tracts. 31 Methyl glyoxal can activate these cells, leading to the production of a variety of cytokines, chemokines, and responses that can in turn protect the body against microbial infection and potentially support immune homeostasis.…”

Section: Copolymer Stability and Breakdown Productsmentioning

confidence: 99%

The β-carotene–oxygen copolymer: its relationship to apocarotenoids and β-carotene function

Mogg¹,

Burton²

2021

Can. J. Chem.

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β-Carotene spontaneously copolymerizes with molecular oxygen to form a β-carotene-oxygen copolymer compound (“copolymer”) as the main product, together with small amounts of many apocarotenoids. Both the addition and scission products are interpreted as being formed during progression through successive free radical β-carotene-oxygen adduct intermediates. The product mixture from full oxidation of β-carotene, lacking both vitamin A and β-carotene, has immunological activities, some of which derive from the copolymer. However, the copolymer’s chemical makeup is unknown. A chemical breakdown study shows the compound to be moderately stable but nevertheless the latent source of many small apocarotenoids. GC-MS analysis with mass-spectral library matching identified a minimum of 45 structures, while more than 90 others remain unassigned. Newly identified products include various small keto carboxylic acids and dicarboxylic acids, several of which are central metabolic intermediates. Also present are glyoxal and methyl glyoxal dialdehydes, recently reported as β-carotene metabolites in plants. Although both compounds at higher concentrations are known to be toxic, at low concentration methyl glyoxal has been reported to be potentially capable of activating an immune response against microbial infection. In plants, advantage is taken of the electrophilic reactivity of specific apocarotenoids derived from β-carotene oxidation to activate protective defenses. Given the copolymer occurs naturally and is a major product of non-enzymatic β-carotene oxidation in stored plants, by partially sequestering apocarotenoid metabolites the copolymer may serve to limit potential toxicity and maintain low cellular apocarotenoid concentrations for signaling purposes. In animals the copolymer may serve as a systemic source of apocarotenoids.

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Mānuka honey-derived methylglyoxal enhances microbial sensing by mucosal-associated invariant T cells

Abstract:
Mānuka honey-derived methylglyoxal enhanced MAIT cell activation by increasing conversion of microbial 5-A-RU to the potent MAIT cell activator, 5-OP-RU.

Cited by 12 publications

References 31 publications

Honey: Another Alternative in the Fight against Antibiotic-Resistant Bacteria?

Honey: Another Alternative in the Fight against Antibiotic-Resistant Bacteria?

Prospects of honey in fighting against COVID-19: pharmacological insights and therapeutic promises

The β-carotene–oxygen copolymer: its relationship to apocarotenoids and β-carotene function

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Mānuka honey-derived methylglyoxal enhances microbial sensing by mucosal-associated invariant T cells

Abstract: Mānuka honey-derived methylglyoxal enhanced MAIT cell activation by increasing conversion of microbial 5-A-RU to the potent MAIT cell activator, 5-OP-RU.

Cited by 12 publications

References 31 publications

Honey: Another Alternative in the Fight against Antibiotic-Resistant Bacteria?

Honey: Another Alternative in the Fight against Antibiotic-Resistant Bacteria?

Prospects of honey in fighting against COVID-19: pharmacological insights and therapeutic promises

The β-carotene–oxygen copolymer: its relationship to apocarotenoids and β-carotene function

Contact Info

Product

Resources

About

Abstract:
Mānuka honey-derived methylglyoxal enhanced MAIT cell activation by increasing conversion of microbial 5-A-RU to the potent MAIT cell activator, 5-OP-RU.