Manufacturing of silicon – Bioactive glass scaffolds by selective laser melting for bone tissue engineering

Rodrigo-Vázquez, C. Sara; Kamboj, Nikhil; Aghayan, Marina; Sáez, Ada; Aza, Antonio H. De; Rodrı́guez, Miguel Á.; Hussainova, Irina

doi:10.1016/j.ceramint.2020.07.171

Cited by 13 publications

(6 citation statements)

References 36 publications

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“…[60] Rodrigo-Vázquez et al obtained composite scaffold combining silicon with bioactive glass (BG) by SLM to pursue structural stability of scaffold, and they found that laser energy could melt the particles to coalesce a continuous structure. [61] In addition to grain size, density is another important factor affecting the mechanical properties of bioceramics. How to achieve the densification of ceramic materials while inhibiting the growth of nanocrystalline has become the key to prepare bioceramic bone scaffold.…”

Section: Bioceramicmentioning

confidence: 99%

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Feng

Zhao

Tang

et al. 2023

Adv Funct Materials

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It is an urgent need that defect repair can develop from simple device fixation to living tissue reconstruction, from short life function replacement to permanent regeneration repair. At present, bone transplantation has become the second largest transplantation surgery after blood transfusion, and artificial bone transplantation generates great hope for the repair and treatment of bone defect. In order to repair bone defect, artificial bone must have good biological properties and sufficient mechanical properties, and it should also have the shape matching to bone defect site and the connected porous structure. For structures and properties requirements of artificial bone, in this review three major challenges faced by artificial bone transplantation are systemtically analyzed and current methods and strategies to address these issues are discussed: 1) the need for developing a type of bone scaffold material with both biological and mechanical properties, 2) the need for realizing the controllable fabrication of individual shape and multistage pore structure of bone scaffold, 3) the need for realizing the transformation from man‐made structure to biological structure. Besides, it summarizes the advantages and disadvantages of these methods and discusses the potential future directions of structural and functional adaptive artificial bone for bone defect regeneration.

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Section: Bioceramicmentioning

confidence: 99%

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Feng

Zhao

Tang

et al. 2023

Adv Funct Materials

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“…However, the process of manufacturing bioinert ceramic coupons through PBF-LB is far more challenging since ceramics usually have higher melting point, brittleness (eventually no plasticity), and poor thermal shock resistance. Furthermore, a rapid heating and cooling process in powder bed results in cracking, and unrequired porosity on the scaffolds [11].…”

Section: Pbf-lb Of Bioinert Ceramicsmentioning

confidence: 99%

Bioinert ceramics scaffolds for bone tissue engineering by laser-based powder bed fusion: a preliminary review

Kamboj,

Piili,

Ganvir

et al. 2023

IOP Conf. Ser.: Mater. Sci. Eng.

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The implementation of laser powder bed fusion (PBF-LB) on ceramics is far more demanding than their metallic and polymeric counterparts for bone tissue engineering (BTE). The review will shed light on bioinert ceramics-based biomaterials manufacturing through PBF-LB incorporating alumina and yttria-stabilized zirconia as oxide-based ceramics and nitride-based ceramics as non-oxide-based ceramics with particular prominence on their properties and requirements for biomedical devices and BTE. The review paper will also classify bioinert scaffolds processed through PBF-LB as a medium to manufacture drug delivery systems (DDS) and to ameliorate critical-sized bone defects based on the fracture site length of the bone with the various modes of functionalization through the incorporation of drugs, stem cells, and growth factors for personalized medicine.

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“…This can be attributed to the lower absorbance of silicate-based bioceramics under the impact of the Nd:YAG laser [ 149 ]. The prospects of fabricating novel silicate-based bioceramics and silicate-based bioglass scaffolds (designed by the phase diagram of CaSiO 3 –Ca 3 (PO 4 ) 2 –MgCa(SiO 3 ) 2 ) by incorporating silicon in the powder bed through Nd:YAG laser are shown in [ 17 , 95 , 150 ]. The potential of pore-driven osteogenesis and sustained delivery of antibiotic vancomycin through silicon-based bioceramic scaffolds was also disclosed [ 35 , 150 ].…”

Section: Bioactive Ceramic Scaffolds Processed By Pbslpmentioning

confidence: 99%

“… Graphical representation of the bioactive ceramic scaffolds depicting compressive strength vs. porosity, calcium phosphatases [ 81 , 82 , 83 , 84 ], bioactive glass ceramics [ 85 , 86 , 87 , 88 ], doped bioactive ceramics [ 89 , 90 , 91 , 92 ], silicates [ 93 , 94 ], and newly fabricated silicon based bioactive ceramics [ 17 , 95 ]. Adapted with permission from [ 17 ].…”

Section: Figurementioning

confidence: 99%

“…However, bioactivity and biocompatibility are reflected not only by the formation of HA on the surfaces but also by inducing molecular signaling pathways. The bioactive ceramic scaffolds possess the potential to trigger the signaling molecules, as shown in Figure 9, at the molecular level (involving bioactive ions [85][86][87][88], doped bioactive ceramics [89][90][91][92], silicates [93,94], and newly fabricated silicon based bioactive ceramics [17,95]. Adapted with permission from [17].…”

Section: Biology-related Characteristicsmentioning

confidence: 99%

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Bioactive Ceramic Scaffolds for Bone Tissue Engineering by Powder Bed Selective Laser Processing: A Review

2021

Self Cite

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The implementation of a powder bed selective laser processing (PBSLP) technique for bioactive ceramics, including selective laser sintering and melting (SLM/SLS), a laser powder bed fusion (L-PBF) approach is far more challenging when compared to its metallic and polymeric counterparts for the fabrication of biomedical materials. Direct PBSLP can offer binder-free fabrication of bioactive scaffolds without involving postprocessing techniques. This review explicitly focuses on the PBSLP technique for bioactive ceramics and encompasses a detailed overview of the PBSLP process and the general requirements and properties of the bioactive scaffolds for bone tissue growth. The bioactive ceramics enclosing calcium phosphate (CaP) and calcium silicates (CS) and their respective composite scaffolds processed through PBSLP are also extensively discussed. This review paper also categorizes the bone regeneration strategies of the bioactive scaffolds processed through PBSLP with the various modes of functionalization through the incorporation of drugs, stem cells, and growth factors to ameliorate critical-sized bone defects based on the fracture site length for personalized medicine.

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Manufacturing of silicon – Bioactive glass scaffolds by selective laser melting for bone tissue engineering

Cited by 13 publications

References 36 publications

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Bioinert ceramics scaffolds for bone tissue engineering by laser-based powder bed fusion: a preliminary review

Bioactive Ceramic Scaffolds for Bone Tissue Engineering by Powder Bed Selective Laser Processing: A Review

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