Manufacturing of pH sensitive PVA/PVP/MWCNT and PVA/PEG/MWCNT nanocomposites: an approach for significant drug release

Nemr, Ahmed El; Serag, Eman; El‐Maghraby, Azza; Fathy, Shadia A.; Hamid, Fatma F. Abdel

doi:10.1080/10601325.2019.1607377

Cited by 19 publications

(4 citation statements)

References 39 publications

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“…A maximum degree of swelling was observed at pH 7, and the swelling degree increased with the amount of MWCNTs. All hydrogel membranes followed non-Fickian mechanisms, and drug release was controlled by varying the amount of filler [95].…”

Section: Polymer Hydrogels and Nanogelsmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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Synthetic polymers, biopolymers, and their nanocomposites are being studied, and some of them are already used in different medical areas. Among the synthetic ones that can be mentioned are polyolefins, fluorinated polymers, polyesters, silicones, and others. Biopolymers such as polysaccharides (chitosan, hyaluronic acid, starch, cellulose, alginates) and proteins (silk, fibroin) have also become widely used and investigated for applications in medicine. Besides synthetic polymers and biopolymers, their nanocomposites, which are hybrids formed by a macromolecular matrix and a nanofiller (mineral or organic), have attracted great attention in the last decades in medicine and in other fields due to their outstanding properties. This review covers studies done recently using the polymers, biopolymers, nanocomposites, polymer micelles, nanomicelles, polymer hydrogels, nanogels, polymersomes, and liposomes used in medicine as drugs or drug carriers for cancer therapy and underlines their responses to internal and external stimuli able to make them more active and efficient. They are able to replace conventional cancer drug carriers, with better results. Appl. Sci. 2019, 9, 3899 2 of 24 nanocomposites offer numerous opportunities in diverse applications, including nanocarriers, tissue engineering, antimicrobials, sensors, etc. These new groups of materials have gained significant research interest due to their novel properties, which are gained through the addition of nanofillers. Polymer nanocomposites have significant potential in disease theranostics, and nanotechnology brings great promise in cancer drug carriers [4].Chemotherapy implies the use of drugs and, besides the drugs, carriers. Common products used as carriers include synthetic polymers, biopolymers, and polymer nanocomposites.Some of the most useful drugs for chemotherapy are toxic chemicals able to inhibit the proliferation of cancer cells. The use of chemotherapeutic drugs has been in part hindered by their poor solubility in water, their short biological half-life, their lack of targeting ability, and the development of multidrug resistance [5]. In the last decades, nanoparticles have shown significant promise as an oncology treatment modality. Responsive polymers represent a promising class of nanoparticles that can trigger delivery through the exploitation of a specific stimuli. Response to a stimulus is one of the most basic processes found in living systems. A tutorial review highlighted the recent developments in polymer-based approaches to internally responsive nanoparticles for oncology [6].One important goal of medicine is to develop carriers that can selectively deliver anticancer drugs to tumor cells with no or minimal side effects in healthy cells [7,8].Polymers and their nanocomposites in different forms, such as micelles, hydrogels, polymersomes, and liposomes, have important potential in cancer diagnosis and treatment.Nanocomposites are popular in many areas due to properties such as their unique design capacity, eco-friendly nature, ...

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Section: Polymer Hydrogels and Nanogelsmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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“…Despite the fact that natural organic adsorbents are mostly biodegradable, some of them adsorb both water and oil, reducing separation efficiency, and others can sink during adsorption in harsh sea conditions [26]. Water softening can also be done with a polymeric-clay-magnetite hybrid resin [27] and manufacturing of pH-sensitive PVA/PVP/MWCNT and PVA/PEG/MWCNT nano-composites for application as drug release [28].…”

Section: Introductionmentioning

confidence: 99%

Electrospun composites nanofibers from cellulose acetate/carbon black as efficient adsorbents for heavy and light machine oil from aquatic environment

et al. 2022

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The feasibility of preparing cellulose acetate/carbon black (CA/CB) composite nanofiber in one step through electrospinning process and investigating its potential oil absorbability and application for machine oil removal from aquatic environment was reported. Different CA/CB composite nanofibers were fabricated by electrospinning of cellulose acetate (CA) solution containing different loads of 0.7, 1.5, and 2.2% CB relative to the weight of CA and labeled as CA/CB0.7, CA/CB1.5, and CA/CB2.2. The scanning electron microscope (SEM) images showed continuous and smooth fiber with submicron diameter ranging from 400–900 nm with good adhering of CB into CA nanofiber. Furthermore, the CA/CB composite nanofibers exhibited high surface area compared with CA nanofiber, which reached 3.057, 2.8718 and 8.244 m2/g for CA/CB0.7, CA/CB1.5 and CA/CB2.2, respectively. Oil adsorption tests were performed with heavy and light machine oils. The CA/CB composite nanofibers showed higher affinity for oil removal from an aqueous solution than pure CA nanofiber. The CA/CB1.5 composite nanofiber has an exceptional performance for the adsorption of both oils, and the maximum oil adsorbed reached 10.6 and 18.3 g/g for light and heavy machine oils, respectively. The kinetic of machine oils adsorption was fitted well by the pseudo-second-order model. Besides, CA/CB composite nanofiber exposed good adsorption properties and respectable reusability after regeneration for four consecutive cycles. The results advocate the excellent potential of as-fabricated CA/CB composite nanofiber as a promising reusable oil adsorbent for oil spill cleanup applications.

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“…Specifically, the CO stretching of pyrrolidone in PVP was identified by the absorption peak at 1654.1 cm –1 . Moreover, the stretching vibrations of C–N were indicated by the peak observed at approximately 1291.6 cm –1 . , The peaks at 1400.1, 1128.1, 1022.1, and 616.5 cm –1 represented C–H, C–O, S–O, and Mo–S bonds, respectively. − In addition, we measured the zeta potential of the Fe/Mo SNZs, which was −21.6 mV (Figure S2).…”

Section: Resultsmentioning

confidence: 99%

Iron/Molybdenum Sulfide Nanozyme Cocatalytic Fenton Reaction for Photothermal/Chemodynamic Efficient Wound Healing

Song,

Cheng,

Qin

et al. 2024

Langmuir

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The issue of bacterial infectious diseases remains a significant concern worldwide, particularly due to the misuse of antibiotics, which has caused the emergence of antibiotic-resistant strains. Fortunately, the rapid development of nanomaterials has propelled significant progress in antimicrobial therapy, offering promising solutions. Among them, the utilization of nanoenzymebased chemodynamic therapy (CDT) has become a highly hopeful approach to combating bacterial infectious diseases. Nevertheless, the application of CDT appears to be facing certain constraints for its low efficiency in the Fenton reaction at the infected site. In this study, we have successfully synthesized a versatile nanozyme, which was a composite of molybdenum sulfide (MoS 2 ) and iron sulfide (FeS 2 ), through the hydrothermal method. The results showed that iron/molybdenum sulfide nanozymes (Fe/Mo SNZs) with desirable peroxidase (POD) mimic activity can generate cytotoxic reactive oxygen species (ROS) by successfully triggering the Fenton reaction. The presence of MoS 2 significantly accelerates the conversion of Fe 2+ /Fe 3+ through a cocatalytic reaction that involves the participation of redox pairs of Mo 4+ /Mo 6+ , thereby enhancing the efficiency of CDT. Additionally, based on the excellent photothermal performance of Fe/Mo SNZs, a nearinfrared (NIR) laser was used to induce localized temperature elevation for photothermal therapy (PTT) and enhance the POD-like nanoenzymatic activity. Notably, both in vitro and in vivo results demonstrated that Fe/Mo SNZs with good broad-spectrum antibacterial properties can help eradicate Gram-negative bacteria like Escherichia coli and Gram-positive bacteria like Staphylococcus aureus. The most exciting thing is that the synergistic PTT/CDT exhibited astonishing antibacterial ability and can achieve complete elimination of bacteria, which promoted wound healing after infection. Overall, this study presents a synergistic PTT/CDT strategy to address antibiotic resistance, providing avenues and directions for enhancing the efficacy of wound healing treatments and offering promising prospects for further clinical use in the near future.

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Manufacturing of pH sensitive PVA/PVP/MWCNT and PVA/PEG/MWCNT nanocomposites: an approach for significant drug release

Cited by 19 publications

References 39 publications

Polymers and Polymer Nanocomposites for Cancer Therapy

Polymers and Polymer Nanocomposites for Cancer Therapy

Electrospun composites nanofibers from cellulose acetate/carbon black as efficient adsorbents for heavy and light machine oil from aquatic environment

Iron/Molybdenum Sulfide Nanozyme Cocatalytic Fenton Reaction for Photothermal/Chemodynamic Efficient Wound Healing

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