Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications

Sierra, Diana; Perea-Mesa, Yuli Paola

doi:10.15446/dyna.v84n203.62742

Cited by 22 publications

(20 citation statements)

References 14 publications

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“…Polyvinyl alcohol (PVA) hydrogels [ 15 , 16 , 17 ], dicarboxylic acids (DCAs) [ 18 ] and cyclodextrins (CDs) [ 19 , 20 ] are commonly used as biomaterials because they have a high biocompatibility and are FDA-approve. CDs were selected because they are able to form inclusion complexes (host-guest type) with several classes of compounds including hydrophobic drugs.…”

Section: Introductionmentioning

confidence: 99%

Rational Design, Synthesis and Evaluation of γ-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform

et al. 2018

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This study describes the in-silico rational design, synthesis and evaluation of cross-linked polyvinyl alcohol hydrogels containing γ-cyclodextrin (γ-CDHSAs) as platforms for the sustained release of prednisone (PDN). Through in-silico studies using semi-empirical quantum mechanical calculations, the effectiveness of 20 dicarboxylic acids to generate a specific cross-linked hydrogel capable of supporting different amounts of γ-cyclodextrin (γ-CD) was evaluated. According to the interaction energies calculated with the in-silico studies, the hydrogel made from PVA cross-linked with succinic acids (SA) was shown to be the best candidate for containing γ-CD. Later, molecular dynamics simulation studies were performed in order to evaluate the intermolecular interactions between PDN and three cross-linked hydrogel formulations with different proportions of γ-CD (2.44%, 4.76% and 9.1%). These three cross-linked hydrogels were synthesized and characterized. The loading and the subsequent release of PDN from the hydrogels were investigated. The in-silico and experimental results showed that the interaction between PDN and γ-CDHSA was mainly produced with the γ-CDs linked to the hydrogels. Thus, the unique structures and properties of γ-CDHSA demonstrated an interesting multiphasic profile that could be utilized as a promising drug carrier for controlled, sustained and localized release of PDN.

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Section: Introductionmentioning

confidence: 99%

Rational Design, Synthesis and Evaluation of γ-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform

et al. 2018

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“…Figure 2b shows the spectrum of Ch-PVA-NaOH-TPP before the adsorption process. It shows the signal 3354 cm −1 of the chitosan OH group, with a slight increase to 3359 cm −1 and the band at 3323 cm −1 of the OH group of the PVA loses definition [57]. A slight decrease of 2918 cm −1 is observed in the 2920 cm −1 signal of the CH group of the chitosan.…”

Section: Characterization By Fourier Transform Infrared Spectroscopymentioning

confidence: 93%

Synthesis of Chitosan-Polyvinyl Alcohol Biopolymers to Eliminate Fluorides from Water

et al. 2020

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The fluoride content in groundwater varies depending on geological configuration. Fluoride problems tend to occur in places where these minerals are most abundant in rocks. The objective of the present work was to synthesize four biopolymers based on chitosan-polyvinyl alcohol (Ch-PVA) cross-linked with sodium tripolyphosphate pentabasic (TPP) and ethylene glycol diglycidyl ether (EGDE) and determine their ability to remove fluoride from water. The characterization of the Ch-PVA beads was performed by way of Scanning Electron Microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR). The percentage of humidity and the point of zero charge were determined. The Ch-PVA beads showed a surface area of 63.87 m2 g−1, a pore size of 7.6 nm, a point of zero charge of 7.4, and 98.6% humidity. The kinetic adsorption study was adjusted to the pseudo-second-order model and the adsorption equilibrium data were adjusted to the Freundlich adsorption isotherm, showing a maximum fluoride adsorption capacity of 12.64 mg g−1 at pH 7 and 30 °C, for the beads of Ch-PVA-NaOH-TPP. According to the thermodynamic parameters: −∆G°, +∆H° and −∆S°, fluoride adsorption is spontaneous, endothermic in nature and there is no random energy change in the solid/liquid interface during the adsorption process.

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“…20 Nonetheless, due to the lack of bioactivity in PVA, it is usually used in combination with other biomaterials or biomolecules to promote its ultimate biological effectiveness. 18,21,22 Previous studies indicated the significant wound healing potential of egg white (EW) as a natural biomaterial that can form a gel network of proteins. 23−26 EW usage is recommended due to its high bioactivity, availability, ease of use, and low production costs.…”

Section: Introductionmentioning

confidence: 99%

Angiogenic Effect of a Nanoniosomal Deferoxamine-Loaded Poly(vinyl alcohol)–Egg White Film as a Promising Wound Dressing

Nour

Imani

Sharifi

2022

ACS Biomater. Sci. Eng.

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Owing to the noticeable increase in the number of patients with impaired wound healing capabilities, developing bioactive wound dressings with supportive physicomechanical and biological properties for clinical wound management has attracted much more attention nowadays. In this regard, engineered dressings with angiogenesis potential are vital for accelerated tissue regeneration. In the current study, nanoniosomal deferoxamine (DFO)-loaded transparent films of egg white−poly(vinyl alcohol) (PVA/EW/ND) were successfully fabricated at three different PVA/EW ratios (1:0, 1:1, and 1:1.5 wt/wt %) through the thin film hydration and solvent casting methods. The developed films' characterizations were carried out using scanning electron microscopy, Fourier transform infrared spectroscopy analysis, uniaxial tensile strength, water uptake, water vapor transmission rate, in vitro degradation, and drug release. The results demonstrated that the various weight ratios of PVA/EW have a significant effect on the microscopic morphology, equilibrium swelling, degradation, and mechanical properties of the films. The drug release profile exhibited a sustained release of DFO with controlled burst-lag phases resembling the Korsmeyer−Peppas pattern. The cytotoxicity and adhesion analysis using human dermal fibroblasts displays the biocompatibility of the developed PVA/EW/ND films and the formation of cellular colonies on the surface. The in vitro angiogenic capability of the developed films evaluated by the scratch wound assay and microbead-assisted tube formation study showed a significant increase in the rate of migration of human umbilical vein endothelial cells and in the number of tube-like structures. Therefore, the achieved results suggest that the presented PVA/EW/ ND film has promising potential for effective wound healing applications.

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Manufacturing and evaluation of Chitosan, PVA and Aloe Vera hydrogels for skin applications

Cited by 22 publications

References 14 publications

Rational Design, Synthesis and Evaluation of γ-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform

Rational Design, Synthesis and Evaluation of γ-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform

Synthesis of Chitosan-Polyvinyl Alcohol Biopolymers to Eliminate Fluorides from Water

Angiogenic Effect of a Nanoniosomal Deferoxamine-Loaded Poly(vinyl alcohol)–Egg White Film as a Promising Wound Dressing

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