Manufacture of Standardized Dried Extracts from Medicinal Brazilian Plants

Oliveira, Wanderley Pereira de; Bott, Rubiana F.; Souza, C. R. F.

doi:10.1080/07373930600612073

Cited by 56 publications

(41 citation statements)

References 22 publications

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“…For the spouted bed, the recovery ratio decreased with the increase in W s /W max ratio, probably due to product accumulation in the bed. These results emphasize the importance of the physical and chemical properties of the composition fed on the overall performance of the drying processes since different results were reported elsewhere (Oliveira et al, 2006).…”

Section: Dryer Performancementioning

confidence: 64%

Processing of Rosmarinus officinalis linne extract on spray and spouted bed dryers

Souza

Schiavetto

Thomazini

et al. 2008

Braz. J. Chem. Eng.

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Received; March 09, 2006 ; Accepted: November 07, 2007) Abstract -This article presents an investigation of the potential of spray and spouted bed technology for the production of dried extracts of Rosmarinus officinalis Linné, popularly known as rosemary. The extractive solution was characterized by loss on drying, extractable matter and total phenolic and flavonoid compounds (chemical markers). The product was characterized by determination of loss on drying, size distribution, morphology, flow properties and thermal degradation and thermal behavior. The spray and spouted bed dryer performance were assessed through estimation of thermal efficiency, product accumulation and product recovery. The parameters studied were the inlet temperature of the spouting gas (80 and 150 o C) and the feed mass flow rate of concentrated extract relative to the evaporation capacity of the dryer, W s /W max (15 to 75%). The atomizing air flow rate was maintained at 20 l/min with a pressure of 196.1 kPa. The spouting gas flow rate used in the drying runs was 40% higher than the gas flow under the condition of minimum spouting. The spray drying gas flow rate was fixed at 0.0118 kg/s. Under the conditions studied, performance in the spray and spouted bed drying of rosemary extract was poor, causing high degradation of the marker compounds (mainly the phenolic compounds). Thus, process improvements are required before use on an industrial scale.

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Section: Dryer Performancementioning

confidence: 64%

Processing of Rosmarinus officinalis linne extract on spray and spouted bed dryers

Souza

Schiavetto

Thomazini

et al. 2008

Braz. J. Chem. Eng.

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“…Obtaining standardized plant extracts has been one of the major challenges for the development of herbal medicines, especially in Brazil, and the herbal industry has sought alternatives to solve this problem, one of which would be the production of standardized dried extracts of medicinal plants aiming establishment of quality control parameters for the vegetable raw material [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Thermal Degradation Kinetics of Kaempferol and Quercetin in the Pre-Formulated of the Standardized Extracts of Poincianella Pyramidalis (Tul.) L. P. Queiroz Obtained by Spray Dryer

Oliveira

Leite

Dantas

et al. 2017

Int J Pharm Pharm Sci

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Objective: The aim of this work was to evaluate the stability and determine the kinetic parameters of degradation of biomarkers kaempferol and quercetin, present in the pre-formulated of the extract of Poincianella pyramidalis obtained by a spray dryer. Methods:A 2 3 experimental design coupled with RSM was applied to evaluate and optimize the effects of processing parameters on the content of chemical markers in dry extracts by a spray dryer. Stability testing was performed to verify the influence of temperature on the degradation of kaempferol and quercetin present in the pre-formulated. The markers contents were determined by HPLC.Results: Surface response analysis showed the influence of the independent variables on the responses of the concentration kaempferol and quercentin biomarkers on the process. The variables of the inlet air temperature, flow feed rate and the adjuvant ratio presented negative responses with significant difference (p<0.05). According to the data obtained in the stability of the pre-formulated studied zero and second orders kinetics models the for degradation of the kaempferol and only second order kinetic model for the quercetin. It was also evaluated reducing the concentration of both biomarkers studied throughout the study. Conclusion:In the present study, it was observed that all independent variables of the drying process by spray dryer showed the greatest influence on the concentration of the studied markers. Two markers had a different thermal behavior compared to the different excipients studied and there was degradation of both the quercentin biomarker and kaempferol during the study period.

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“…Important advantages attributed to the dried extracts over conventional forms are the facility of standardization, lower storage costs and higher concentration and stability of active substances. However, the drying method and the operating conditions used for the production of the dried extract may impact the product physicochemical properties, and can originate varying degrees of active compounds loss (Runha et al, 2001;Oliveira, Bott, Souza, 2006).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity and physical-chemical properties of spray and spouted bed dried extracts of Bauhinia forficata

Souza

Georgetti

Salvador

et al. 2009

Braz. J. Pharm. Sci.

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Two distinct drying methods (spouted bed and spray drying) were used for production of dried extracts of Bauhinia forficata Link (Leguminosae, Caesalpinoideae). High-quality powder products in terms of physical and chemical properties were obtained. HPLC fingerprints revealed that the chromatographic profiles of flavonoid compounds present in the dried extract did not change significantly, due to drying. In general, the spouted bed drying caused a degradation of total flavonoids than was lower than that of the spray drying. Antioxidant properties of the dried extract, examined by their radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl radical (DPPH · ) and inhibition of lipid peroxidation induced by Fe +2 assays (LPO), confirmed their antioxidant potential. The slight reduction in scavenging activity of the dried extracts may be associated with the occurrence of oxidative reactions, decomposition or losses of thermolabile compounds, induced by the heat.Uniterms: Bauhinia forficata/antioxidant activity. Bauhinia forficata/dried extract/properties. Flavonoids/ qualitative analysis. Spouted bed/utilization. Spray drying/utilization.Neste trabalho foram utilizados dois distintos secadores (leito de jorro e spray dryer) para a produção de extratos secos de Bauhinia forficata Link (Leguminosae, Caesalpinoideae) obtendo-se um produto seco com elevada qualidade em termos de suas propriedades físicas e químicas. Análises qualitativas obtidas por CLAE revelam que os perfis cromatográficos dos compostos flavonóides presentes nos extratos secos não apresentaram significativas mudanças durante a secagem quando comparados aos perfis obtidos para os extratos concentrados. Em geral, a secagem por leito de jorro acarreta menores perdas dos flavonóides totais do que a secagem em spray drying. A atividade antioxidante dos extratos secos foi examinada pelos métodos de (DPPH · ) e peroxidação lipídica induzida por Fe +2 (LPO). Uma pequena redução na atividade sequestradora de radicais livres observada para os extratos secos pode ser associada com a ocorrência de reações oxidativas, decomposição e/ou perdas de compostos termolábeis induzidas pelo calor.Unitermos: Bauhinia forficata/atividade antioxidante. Bauhinia forficata/extrato seco/propriedades. Flavonóides/análise qualitativa. Leito de jorro/utilização. Spray drying/utilização.

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Manufacture of Standardized Dried Extracts from Medicinal Brazilian Plants

Cited by 56 publications

References 22 publications

Processing of Rosmarinus officinalis linne extract on spray and spouted bed dryers

Processing of Rosmarinus officinalis linne extract on spray and spouted bed dryers

Thermal Degradation Kinetics of Kaempferol and Quercetin in the Pre-Formulated of the Standardized Extracts of Poincianella Pyramidalis (Tul.) L. P. Queiroz Obtained by Spray Dryer

Antioxidant activity and physical-chemical properties of spray and spouted bed dried extracts of Bauhinia forficata

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