Manufacture of high-aspect-ratio micro-hair sensor arrays

Schmitz, Georg J.; Brücker, Christoph; Jacobs, Philipp

doi:10.1088/0960-1317/15/10/016

Cited by 31 publications

(17 citation statements)

References 21 publications

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“…Fabrication of micropost arrays with a high density and aspect ratio (micropost height/micropost diameter) has gained increased interest in recent years [Petronis et al, 2003;Mohrdieck et al, 2005;Schmitz et al, 2005]. This is essential in order to extend the micropost array-based technique to measure CTFs for cells of smaller size and/or producing less force.…”

Section: Discussionmentioning

confidence: 99%

Development of micropost force sensor array with culture experiments for determination of cell traction forces

Xie

Starr

et al. 2007

Cell Motil. Cytoskeleton

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Cell traction forces (CTFs) are critical for cell motility and cell shape maintenance. As such, they play a fundamental role in many biological processes such as angiogenesis, embryogenesis, inflammation, and wound healing. To determine CTFs at the sub-cellular level with high sensitivity, we have developed high density micropost force sensor array (MFSA), which consists of an array of vertically standing poly(dimethylsiloxane) (PDMS) microposts, 2 microm in diameter and 6 microm in height, with a center-to-center distance of 4 microm. In combination with new image analysis algorithms, the MFSA can achieve a spatial resolution of 40 nm and a force sensitivity of 0.5 nN. Culture experiments with various types of cells showed that this MFSA technology can effectively determine CTFs of cells with different sizes and traction force magnitudes.

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Section: Discussionmentioning

confidence: 99%

Development of micropost force sensor array with culture experiments for determination of cell traction forces

Xie

Starr

et al. 2007

Cell Motil. Cytoskeleton

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“…1). Micropillars were fabricated according the method described by Schmitz et al (2005). In all experiments, pillars with a diameter of 50 m and lengths of 500 m were used.…”

Section: Methodsmentioning

confidence: 99%

Measuring Flow Velocity and Flow Direction by Spatial and Temporal Analysis of Flow Fluctuations

Chagnaud¹,

Brücker²,

Hofmann³

et al. 2008

J. Neurosci.

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If exposed to bulk water flow, fish lateral line afferents respond only to flow fluctuations (AC) and not to the steady (DC) component of the flow. Consequently, a single lateral line afferent can encode neither bulk flow direction nor velocity. It is possible, however, for a fish to obtain bulk flow information using multiple afferents that respond only to flow fluctuations. We show by means of particle image velocimetry that, if a flow contains fluctuations, these fluctuations propagate with the flow. A cross-correlation of water motion measured at an upstream point with that at a downstream point can then provide information about flow velocity and flow direction. In this study, we recorded from pairs of primary lateral line afferents while a fish was exposed to either bulk water flow, or to the water motion caused by a moving object. We confirm that lateral line afferents responded to the flow fluctuations and not to the DC component of the flow, and that responses of many fiber pairs were highly correlated, if they were time-shifted to correct for gross flow velocity and gross flow direction. To prove that a cross-correlation mechanism can be used to retrieve the information about gross flow velocity and direction, we measured the flow-induced bending motions of two flexible micropillars separated in a downstream direction. A cross-correlation of the bending motions of these micropillars did indeed produce an accurate estimate of the velocity vector along the direction of the micropillars.

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“…10,11 The use of flexible, permeable media to bound a flowing fluid is also acquiring momentum in applications related to both sensing [12][13][14] and manipulating [15][16][17][18][19][20][21][22] near-wall transitional and turbulent structures. Such media often take the form of dense bundles of pillars, hinged at a rigid base and free to vibrate under the forcing provided by the fluid, so that elastic potential energy can be easily transferred to the fluid and back.…”

Section: Introductionmentioning

confidence: 99%

Instabilities in the boundary layer over a permeable, compliant wall

2014

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16 pagesInternational audienceLocal linear stability of swept and unswept incompressible boundary layers developing over compliant, fluid-saturated, porous plates is considered in the limit of small permeability. The analysis is meant to yield preliminary indications on the possible stabilization induced on the flow's hydrodynamic and hydroelastic modes by poroelastic media, such as those occurring in many natural and technological settings. As far as hydrodynamic modes are concerned, the main stabilizing effect is that of compliance, which however couples weakly to low-frequency crossflow modes. Permeability plays a damping role on hydroelastic modes, which here take the form of travelling wave flutter instabilities. The passive control of instabilities through poroelastic coatings specifically designed to selectively exploit the effect of compliance and/or permeability is a subject worthy of future research efforts

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Manufacture of high-aspect-ratio micro-hair sensor arrays

Cited by 31 publications

References 21 publications

Development of micropost force sensor array with culture experiments for determination of cell traction forces

Development of micropost force sensor array with culture experiments for determination of cell traction forces

Measuring Flow Velocity and Flow Direction by Spatial and Temporal Analysis of Flow Fluctuations

Instabilities in the boundary layer over a permeable, compliant wall

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