Manufacture and Characterisation of Porous PLA Scaffolds

Natacha, Rodrigues; Benning, Matthew; Ferreira, Ana Marina; Dixon, Luke I.; Dalgarno, Kenneth

doi:10.1016/j.procir.2015.07.025

Cited by 70 publications

(36 citation statements)

References 18 publications

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“…As reported by Liu et al [20] , PLLA porous scaffolds exhibited a reduction in mass and molecular weight during an in vitro degradation time of 200 days. Rodrigues et al [21] studied degradation process of porous PLA scaffold immersed in phosphate-buffered-saline solution, and revealed that there was no significant change in molecular weight over 8 weeks. Zamiri et al [22] compared the in vitro degradation behaviour of PLLA and PLLA/PLGA braided scaffolds over 25 weeks, and the mass loss was found very limited for PLLA braided scaffolds whereas PLLA/PLGA braided scaffolds experienced a mass loss of 64%.…”

Section: Degradation Behaviourmentioning

confidence: 99%

“…The in vitro degradation study by Liu et al [26] showed that PLLA porous scaffolds exhibited a reduction in compressive modulus and strength during a degradation time of 200 days. Recently, Rodrigues et al [21] carried out an in vitro degradation study of porous PLA scaffold immersed in phosphate-buffered-saline solution for 8 weeks. The study revealed that compressive properties (i.e., compressive modulus and stress at yield) of the scaffolds maintained constant during the initial 6 weeks and increased significantly at week 8.…”

Section: Degradation Behaviourmentioning

confidence: 99%

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Research into biodegradable polymeric stents: a review of experimental and modelling work

Qiu¹,

Zhao²

2018

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Bioresorbable stents (BRSs) are regarded as the next-generation medical devices to treat blocked or diseased arteries.The use of BRSs aims to reduce the risk of late stent thrombosis and long-term tissue inflammation associated with permanent metallic stents. BRSs are designed to relieve symptoms immediately and also provide mechanical support for an appropriate time period before they are fully absorbed by human body. To promote clinical adoption of BRSs or even to substitute metallic stents, the mechanical performance of BRSs needs to be thoroughly investigated and quantitatively characterised, especially over the full period of degradation. This paper offers a review of current research status of polymeric BRSs, covering both experimental and modelling work. Review of experimental studies highlighted the effects of stent designs and materials on the behaviour of polymeric BRSs. Computational work was able to simulate crimping, expansion and degradation of polymeric BRSs and the results were useful for performance assessment. In summary, the development of polymeric BRSs is still at an early stage, and further research is urgently required for a better understanding and control of their mechanical performance.

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Section: Degradation Behaviourmentioning

confidence: 99%

Section: Degradation Behaviourmentioning

confidence: 99%

Research into biodegradable polymeric stents: a review of experimental and modelling work

Qiu¹,

Zhao²

2018

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“…Combining FDM process and developed Polywax based on PE materials investigated by Wang et al Lee et al have studied the effect of various printing parameters such as air gap, raster orientation, color, bead width, and model temperature for ABS material and produced methods both Fused Deposition Modeling and Nano composite deposition system . Rodrigues et al prepared PLA samples from 3D Printing machine and 3D Printing laser cut bar . PLA materials’ mechanical properties are tested, comparing the influence of the properties after laser cutting lower compressive values are acquired.…”

Section: Introductionmentioning

confidence: 99%

Designing and Manufacturing of Polymer‐Foam Hybrid Materials Using Fused Deposition Modeling

et al. 2019

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3D printing technology has grown in the past decades. Faster and cheaper techniques are developed to produce complicated parts. It is also known that the hybrid material approach is beneficial in material selection. In this way, the mechanical properties are improved by using the materials instead of using them alone. In this study, TPE (Thermoplastic Elastomer) þ Air and TPE þ Foam hybrid materials are designed to get better performance than those obtained during only TPE material using. TPE are produced by 3D printer using FDM (Fused Deposition Modeling) technique. Fabricated hybrid materials are exposed to compression test according to ASTM D695 standard. The effect of different filling ratios and infill patterns are investigated. As a result of the study, the highest compressive strength is acquired with triangle infill pattern. These mechanical characteristics are increased in all infill patterns with increasing filling ratio. When TPE þ Air and TPE þ Foam hybrid materials are compared, higher Young's modulus and compressive yield strength values (about 95% increasing) are procured with TPE þ foam hybrid materials. This hybrid material approach, rapid prototyping, and the combined use of foam material are provided a significant increment in compressive strength and a wide range of material properties can be obtained.

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“…The in vitro degradation study by Liu et al (2014) showed that PLLA porous scaffolds exhibited a reduction in mechanical properties (compressive modulus and strength), mass and molecular weight during a degradation time of 200 days. Rodrigues et al (2016) carried out an in vitro degradation study of porous PLA scaffold immersed in phosphate-buffered-saline solution for 8 weeks. The study revealed that there was no significant change for molecular weight, whereas compressive properties (i.e., compressive modulus and stress at yield) of the scaffolds maintained constant during the initial 6 weeks and increased significantly at week 8.…”

Section: Introductionmentioning

confidence: 99%

Effect of two-year degradation on mechanical interaction between a bioresorbable scaffold and blood vessel

Qiu

Abunassar

et al. 2018

Journal of the Mechanical Behavior of Biomedical Materials

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This paper aims to evaluate the mechanical behaviour of a bioresorbable polymeric coronary scaffold using finite element method, focusing on scaffold-artery interaction during degradation and vessel remodelling. A series of nonlinear stress-strain responses was constructed to match the experimental measurement of radial stiffness and strength for polymeric scaffolds over 2-year in-vitro degradation times. Degradation process was modelled by incorporating the change of material property as a function of time. Vessel remodelling was realised by changing the size of artery-plaque system manually, according to the clinical data in literature. Over degradation times, stress on the scaffold tended to increase firstly and then decreased gradually, corresponding to the changing yield stress of the scaffold material; whereas the stress on the plaque and arterial layers showed a continuous decrease. In addition, stress reduction was also observed for scaffold, plaque and artery in the simulations with the consideration of vessel remodelling. For the first time, the work offered insights into mechanical interaction between a bioresorbable scaffold and blood vessel during two-year in-vitro degradation, which has significance in assisting with further development of bioresorbable implants for treating cardiovascular diseases.

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Manufacture and Characterisation of Porous PLA Scaffolds

Cited by 70 publications

References 18 publications

Research into biodegradable polymeric stents: a review of experimental and modelling work

Research into biodegradable polymeric stents: a review of experimental and modelling work

Designing and Manufacturing of Polymer‐Foam Hybrid Materials Using Fused Deposition Modeling

Effect of two-year degradation on mechanical interaction between a bioresorbable scaffold and blood vessel

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