Manual of Skin Diseases

Sauer, Gordon C.

doi:10.1097/00000441-196701000-00029

Cited by 6 publications

(9 citation statements)

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“…DISCUSSION Although there is some controversy as to the effectiveness of topical chemotherapy in certain types of local infections, there are several clinical situations in which topical therapy is apparently beneficial (1, 2, 5, 7). Topical antimicrobial formulations are widely used in the field of dermatology (9). Because problems related to the development of resistance, sensitization, toxicity, and other undesirable effects have been encountered with several of the substances commonly used topically, the search has continued for new and more efficacious substances that can be utilized as topical chemotherapeutic agents.…”

Section: Resultsmentioning

confidence: 99%

Responsiveness of Experimental Surgical-Wound Infections to Topical Chemotherapy

McRipley¹,

Whitney²

1976

Antimicrob Agents Chemother

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Topical agents freshly formulated in a cream base vehicle as well as commercial topical preparations were used to evaluate in mice the responsiveness of experimental surgical wounds infected with Staphylococcus aureus or Pseudomonas aeruginosa to chemotherapy. The responsiveness of the infections to therapy or the efficacy of a topical agent was assessed primarily by means of wound counts of the infecting organism before and after the employment of an immediate (prophylactic) or delayed (therapeutic) treatment regimen. From tests of several concentrations of an agent formulated in the vehicle, a median effective dose could be determined. In the case of the lethal P. aeruginosa infection, a median protective dose could be determined. Both infections were found to be quite susceptible to treatment with those topical agents that demonstrated good activity in vitro against the test organisms. The results of the investigation indicated that the model infections were suitable for the screening of potential topical agents in vivo.In the preceding paper experimental surgical-wound infections in mice were described and characterized (6). In addition, a rapid method for quantitating bacteria in the wound infections was presented. In this paper the response of the surgical-wound infections to chemotherapy with various topical antimicrobial agents is explored. Freshly formulated antibacterial agents, commonly administered topically, as well as commercial topical antimicrobial products were employed in the study. These topical formulations were used not only for evaluating the responsiveness of the experimental infections to chemotherapy but also for demonstrating how, using standardized methodology, the model infections can be employed to assess various measures oftopical efficacy.MATERIALS AND METHODS Antibacterial agents. The antibiotics and chemicals used in this study were gentamicin sulfate, 634 ,ug/mg (Schering Corp.); polymyxin B sulfate, 7,956

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Section: Resultsmentioning

confidence: 99%

Responsiveness of Experimental Surgical-Wound Infections to Topical Chemotherapy

McRipley¹,

Whitney²

1976

Antimicrob Agents Chemother

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“…On the other hand, a variety of skin diseases, such as atopic dermatitis, senile xerosis or psoriasis tend to worsen during the dry winter season 6,7 . These skin diseases are also characterized by itch sensation 8–10 .…”

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confidence: 99%

Dry environment increases mast cell number and histamine content in dermis in hairless mice

Ashida¹,

Denda²

2003

Br J Dermatol

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“…Seasonal changes affect the condition of normal skin and may trigger various cutaneous disorders [ 96,119 ] . Abundant indirect evidence indicates that decreased humidity precipitates these disorders, whereas, in contrast, increased skin hydration appears to ameliorate these conditions.…”

Section: Humiditymentioning

confidence: 99%

Sensory Systems of Epidermal Keratinocytes

Denda

2012

Treatment of Dry Skin Syndrome

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Manual of Skin Diseases

Cited by 6 publications

References 0 publications

Responsiveness of Experimental Surgical-Wound Infections to Topical Chemotherapy

Responsiveness of Experimental Surgical-Wound Infections to Topical Chemotherapy

Dry environment increases mast cell number and histamine content in dermis in hairless mice

Sensory Systems of Epidermal Keratinocytes

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