Manual for Staging of Cancer, 3rd edition

Beahrs, Oliver H.; Henson, Donald E.; Hutter, R. V. P.; Myers, Max H.

doi:10.1097/00000421-198812000-00027

Cited by 431 publications

(472 citation statements)

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“…2,10 Lymph nodes were classified as malignant based on established sonographic criteria (see Table 2). Malignant lymph nodes appeared as large (Ͼ 1 cm), round, hypoechoic structures with a discrete border often directly adjacent to an esophageal mass.…”

Section: Methodsmentioning

confidence: 99%

The accuracy of endoscopic ultrasound for restaging esophageal carcinoma after chemoradiation therapy

Kalha

Kaw

Fukami

et al. 2004

Cancer

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The study of fault detection and diagnosis of electrical machines, in particular induction motors, as well as the teaching of their behavior requires practical experience in this field. To provide this experience to the students this paper presents an experimental system that can be used with a standard industrial electrical induction machine. This system is based on only one healthy induction machine that is operated under faulty operating modes. Several fault types such as stator winding faults, bearing faults, or broken bars can be tested. The developed system also allows testing the behavior of the electrical machine for different load types. Several typical loads in which the torque depends of time or speed were implemented. The system is based on computer equipment with a DSPIC, a testing system and an induction machine. © 2010 Wiley Periodicals, Inc. Comput Appl Eng Educ 20: 611–618, 2012

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Section: Methodsmentioning

confidence: 99%

The accuracy of endoscopic ultrasound for restaging esophageal carcinoma after chemoradiation therapy

Kalha

Kaw

Fukami

et al. 2004

Cancer

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“…Clinical status was determined with the 1997 UICC/AJCC staging system. 32 Among 44 Japanese cases, 36 received radiotherapy with cisplatin-based concurrent chemotherapy; 10 patients received cisplatin (100 mg/total) by arterial infusion on days 1, 22 and 43; and the other 26 patients received cisplatin by intravenous infusion (100 mg/m 2 ) on days 1, 22 and 43 with 5-fluorouracil (800 mg/m 2 ) on days 1-5, 22-27 and 43-48. The other 8 patients received radiotherapy only.…”

Section: Patientsmentioning

confidence: 99%

Epstein‐Barr virus latent membrane protein 1 induces the matrix metalloproteinase‐1 promoter via an Ets binding site formed by a single nucleotide polymorphism: Enhanced susceptibility to nasopharyngeal carcinoma

Kondo

Wakisaka

Schell

et al. 2005

Intl Journal of Cancer

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The Epstein-Barr Virus (EBV) latent membrane protein 1 (LMP1) has a significant role in several malignancies, including nasopharyngeal carcinoma (NPC). LMP1 is the principal oncoprotein, and we have shown that it also induces a set of factors that mediates invasion, angiogenesis and metastasis. Matrix metalloproteinase-1 (MMP1) is also involved in several malignancies. A single guanine insertion polymorphism (2G) in the MMP1 promoter creates an Ets binding site that causes high levels of transcription and correlates with risk for some malignancies. Here, we evaluate the impact of this 2G insertion type on NPC. We genotyped 44 Japanese and 39 Taiwanese NPC patients, as well as 58 Japanese and 23 Taiwanese healthy controls. The proportion of 2G homozygotes was higher in the NPC groups than in controls (Japanese: p = 0.02, odds ratio (OR) = 2.49; Taiwanese: p = 0.02, OR = 3.66). An analysis of overall survival rates in the patients with NPC, and the 1G/1G genotype disclosed a favorable prognosis (5-year survival rate = 100%, p = 0.04). Multivariate analysis showed that 1G/1G has independent prognostic significance. We also examined whether LMP1 enhances MMP1 expression in epithelial cells in culture. LMP1-transfected cells with 2G/2G genotype expressed MMP1, which was abolished by activator protein-1 (AP1) dominant-negative (DN) and Ets-DN. LMP1 also induced active MMP3, which can cleave latent MMP1, and AP1-DN and Ets-DN suppressed the MMP3 expression. These results suggest that LMP1-induced MMP1 and MMP3 are closely linked and show that LMP1 activates MMP1 via an Ets binding site formed by 2G, which is a candidate marker for both risk and prognosis of NPC. ' 2005 Wiley-Liss, Inc.Key words: SNP; MMP1; LMP1; Ets binding site; AP1EBV is a human herpes virus associated with an increasing number of malignancies, both lymphoid and epithelial in origin, including Burkitt's lymphoma and nasopharyngeal carcinoma (NPC). 1-3 Among the viral proteins expressed in the transformed cells, the nuclear antigens, Epstein-Barr nuclear antigen 2 (EBNA2), EBNA3A, EBNA3c and the integral membrane protein called latent membrane protein 1 (LMP1) are essential for growth transformation and immortalization of resting B lymphocytes. 4,5 The carboxyl-terminal portion of LMP1, which is in the cytoplasmic domain of the protein, contains 2 functional domains. The proximal domain, COOH-terminal activation region 1 (CTAR1), interacts with tumor necrosis factor receptor-associated factors and induces nuclear factor-kB (NF-kB). 6,7 The distal domain, CTAR2, is the dominant NF-kB and c-Jun N-terminal kinase (JNK) activating region of LMP1. 8,9 Previously, we showed that the CTAR1 domain also induces Ets1, a member of the Ets transcription family, and recognizes specific nucleotides sequences with a GGAA/T core sequence. We also showed that LMP1 induces c-Met, which enhances cell motility, via Ets1. [10][11][12] We have shown that LMP1 induces MMP9, a type IV collagenase that is a key enzyme in metastasis and cell invasion. 12-15 However, MMP9 is un...

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“…Lung tumour specimens were histopathologically diagnosed according to the 1981 World Health Organization classification (WHO, 1982). The postsurgical pTMN stage was determined according to the guidelines of the American Joint Committee on Cancer (Bearhs et al, 1992). Smokers analysed in this study were current smokers, including individuals who stopped smoking 3 months before surgery.…”

Section: Cultured Cell Lines Tumour Samples and Patientsmentioning

confidence: 99%

Frequent expression of new cancer/testis gene D40/AF15q14 in lung cancers of smokers

et al. 2002

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We found a significant correlation between lung cancer in smokers and the expression of a human gene, D40, predominantly expressed in testis and cancers. In an attempt to clone a novel human gene, we screened a cDNA library derived from a human B cell line and obtained a cDNA clone that we refer to as D40. A search for public databases for sequence homologies showed that the D40 gene is identical to AF15q14. D40 mRNA is predominantly expressed in normal testis tissue. However, this gene is also expressed in various human tumour cell lines and primary tumours derived from various organs and tissues, such as lung cancer. We examined the relationship between D40 expression and clinico-pathological characteristics of tumours in primary lung cancer. D40 expression did not significantly correlate with either histological type or pathological tumour stage. However, D40 expression was observed more frequently in poorly differentiated tumours than in well or moderately differentiated ones. Furthermore, the incidence of D40 expression was significantly higher in tumours from patients who smoke than in those from non-smokers. D40/AF15q14 is the first gene in the cancer/testis family for which expression is related to the smoking habits of cancer patients.

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Manual for Staging of Cancer, 3rd edition

Cited by 431 publications

References 0 publications

The accuracy of endoscopic ultrasound for restaging esophageal carcinoma after chemoradiation therapy

The accuracy of endoscopic ultrasound for restaging esophageal carcinoma after chemoradiation therapy

Epstein‐Barr virus latent membrane protein 1 induces the matrix metalloproteinase‐1 promoter via an Ets binding site formed by a single nucleotide polymorphism: Enhanced susceptibility to nasopharyngeal carcinoma

Frequent expression of new cancer/testis gene D40/AF15q14 in lung cancers of smokers

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