Mantle cell lymphoma presenting as acute appendicitis

Chae, Max; Cheema, Muhammad Arslan

doi:10.1016/j.ijscr.2014.10.068

Cited by 8 publications

(7 citation statements)

References 9 publications

(13 reference statements)

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“…Most appendiceal lymphomas are non-Hodgkin's lymphoma, and the most common histologic type is large B-cell lymphoma, followed by Burkitt lymphoma [9]. Although gastrointestinal lymphoma is the most common form of extranodal lymphoma, patients with mantle cell lymphoma of the appendix are rare, and only a few cases can be found in the literature (Table 2) [10][11][12][13][14][15]. Compared with other B-cell lymphomas, MCLs have poorer long-term survival and earlier relapse even with appropriate therapy.…”

Section: Discussionmentioning

confidence: 99%

Mantle Cell Lymphoma Presenting as Acute Abdominal Syndrome: A Rare Case Report and Literature Review

et al. 2021

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Background: Acute abdominal syndrome can be caused by several possible reasons. The most common causes are perforation of a gastroduodenal ulcer, peritonitis, intestinal obstructions, and perforation of an appendix or fallopian tube. Fever and pain can be caused by an appendicitis or sigmoiditis. Appendiceal lymphoma is a rare disease that is usually found incidentally during appendectomy. Most of the cases are non-Hodgkin’s lymphomas. Mantle cell lymphoma is an aggressive B-cell non-Hodgkin’s lymphoma with a poorer prognosis than other B-cell lymphomas; thus, a definitive diagnosis is essential. Case Summary: A 60-year-old man presented with right lower quadrant pain. He denied any nausea, vomiting or anorexia and was afebrile. The physical examination revealed right lower quadrant abdomen tenderness. The computed tomography scan revealed periappendiceal fatty stranding with a swollen appendix, approximately 2 cm in diameter and prominent paraaortic, portacaval and mesenteric lymph nodes. A diagnosis of acute appendicitis was made, and laparoscopic appendectomy was performed immediately. The subsequent pathological examination revealed severe congestion with lymphoid hyperplasia. The immunohistochemistry stains revealed positive staining for cluster of differentiation (CD) CD20, B-cell lymphoma-2 (Bcl-2), cyclin D1, SRY-box transcription factor-11 (SOX-11), immunoglobulin D (IgD) and immunoglobulin M (IgM) but negative staining for CD3, CD5, CD10 and CD23. 18F-FDG positron emission tomography showed peripheral lymph node involvement, while the bone marrow biopsy showed negative findings. Therefore, a diagnosis of mantle cell lymphoma, Ann Arbor stage IVA, was made. The patient received postoperative combination chemotherapy and remained in a stable condition over a 1-year follow-up period. Conclusion: We report an uncommon case that initially presented as acute appendicitis, for which a final diagnosis of mantle cell lymphoma was made. In comparison with other B-cell lymphomas, mantle cell lymphoma has a poorer prognosis, and positive immunochemical staining of cyclin D1 and SOX-11 is useful for differentiating mantle cell lymphoma from other appendiceal lymphomas and treating patients appropriately. Physicians and nursing staff should be also aware of the associated complications and management in these patients.

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Section: Discussionmentioning

confidence: 99%

Mantle Cell Lymphoma Presenting as Acute Abdominal Syndrome: A Rare Case Report and Literature Review

et al. 2021

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“…Gastrointestinal tract lymphoma accounts for 4-20% of non-Hodgkin's lymphomas and 30-45% of extranodal cases. 6 The stomach is most commonly involved, followed by the small intestine, pharynx, colon, and esophagus. Lymphoma of the ileum is the most common extragastric site.…”

Section: Discussionmentioning

confidence: 99%

Mucosa-associated lymphoid tissue lymphoma of the appendix stump: a case report

Hernandez.Bustos¹,

Salgado-Vives²,

Chávez-Serna³

et al. 2020

Int J Res Med Sci

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Primary lymphomas of the appendix occur in 0.015% of all gastrointestinal lymphomas. The most common manifestation is acute appendicitis secondary to luminal obstruction. The most common is immunophenotype B low-grade non-Hodgkin lymphoma. A 53-year-old male, with a previous three-week surgical history due to acute appendicitis, histopathological report of acute appendicitis and lymphoid hyperplasia. Later, he was admitted, with abdominal pain in the right iliac fossa, an abdominal ultrasound and simple abdominal tomography were performed, with suspicion of residual abscess. Surgical intervention is decided, observing paracecal tumor in the emergency site of the appendix, the tumor is removed. Pathological study that reports an appendicular base infiltrated by mucosa-associated lymphoma. The diagnosis of appendicular tumors is mostly, intraoperatively incidental. It is necessary to have the diagnostic possibility when performing an appendectomy, since it changes the prognosis and treatment of the patient.

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“…Involvement of the appendix is an exceedingly rare finding and has been described only in isolated case reports (Table 1). To our knowledge, only four cases of recurrent lymphoma in the appendix have been reported in the literature (Tsujimura et al, 2000;Katz, Stein, & Mazzie, 2002;Pickhardt et al, 2002;Chae, Kumar, & Cheema, 2015). The gastrointestinal tract is the most common site of extranodal lymphoma, these account for 4-20% of all primary NHLs and 30-45% of extranodal cases (d' Amore et al, 1994).…”

Section: Discussionmentioning

confidence: 99%