Mantle cell lymphoma involving the thyroid: a case report

Hojilla, Carlo V.; Rajab, Amr; Craddock, Kenneth J.; Rotstein, Lorne; Santos, Gilda da Cunha

doi:10.1111/cyt.12266

Cited by 4 publications

(6 citation statements)

References 12 publications

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“…The case by Hojilla and co‐authors was the first report on the cytological diagnosis of MCL involving the thyroid in a patient with a known MCL and the second case of thyroid MCL with an FNA description but which was diagnosed on histology . Our additional case highlights that a cytological diagnosis of MCL is feasible when a cell‐block is obtained from the FNA.…”

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confidence: 62%

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Mantle cell lymphoma of the thyroid: The helpful role of cell‐blocks

et al. 2017

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| 343 extremely simple, fast and low-cost technique, the "cyto-cell block" approach to thyroid nodule assessment may be extremely helpful in routine practice both in epithelial and in lymphoproliferative diseases.The experience of Zhang and co-authors on a large series of nodal and extra-nodal lymphoproliferative disorders studied with cell-block, demonstrated that the combination of morphology and cell block immunocytochemistry offers significant diagnostic accuracy to assess specific lymphoma subtypes, such as diffuse large B-cell lymphoma, plasmacytoma and MCL.In the present case, the immunoreactivity with cyclin D1 was per se already diagnostic of MCL. Moreover, cell block immunophenotyping provides higher diagnostic accuracy for Hodgkin's lymphoma and some T-cell lymphomas, which cannot be be diagnosed by flow cytometry. In contrast, difficulties concerning the diagnosis of marginal cell lymphoma and follicular lymphoma on cell-block specimens are related to the inability to evaluate lymphoepithelial lesions and follicular structures. 6 In summary, a cell-block specimen obtained from FNA has several advantages: it is a simple, fast and low-cost technique, it allows the morphological evaluation of the lesion, it is suitable for immunocytochemistry, it can be used for cytogenetic and molecular analysis, and, as with every paraffin-embedded tissue, it can be easily archived and re-used.

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confidence: 62%

“…We have read with interest the report by Hojilla and co‐authors on the first case of mantle cell lymphoma (MCL) of the thyroid diagnosed on cytological smears. We have recently encountered a similar case of blastoid mantle cell lymphoma of the thyroid diagnosed on a cytology cell‐block preparation.…”

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confidence: 99%

Mantle cell lymphoma of the thyroid: The helpful role of cell‐blocks

et al. 2017

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“…It is unclear whether the above-mentioned prognostic indices and treatment regimens apply to MCL that presents as a PTL. One case report highlighted the discovery of MCL in the thyroid after a primary presentation in the gastrointestinal tract [ 9 ]. This patient had a low Ki-67 index [10–15%] and had good survival with continued surveillance.…”

Section: Discussionmentioning

confidence: 99%

Mantle Cell Lymphoma in the Thyroid: A Rare Presentation

Siddiqui

Rao

Galera

et al. 2017

Case Reports in Pathology

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Background While 2% of all extranodal Non-Hodgkin Lymphomas present in the thyroid, there exists insufficient data to describe the incidence of mantle cell lymphoma in the thyroid. A case series of 1400 patients revealed that <1% of thyroid lymphomas may be MCL; hence better understanding of the disease course is essential. Patient Findings A 65-year-old female was referred for a multinodular goiter. Multiple fine needle aspirations from the dominant right nodule were consistent with Hashimoto's thyroiditis and flow cytometry was negative. Due to progressing dysphagia, she underwent total thyroidectomy. Summary Pathology revealed MCL with mantle zone growth pattern in the right thyroid. Flow cytometry showed monoclonal B cells comprising 9% of total cells. The Ki-67 index was 10%. She was diagnosed as having stage IIE MCL and offered conservative management by medical oncology, given that she had no B symptoms. Conclusion Though chemotherapy is the treatment of choice in MCL, a subset of patients with low-grade disease may be observed. As in our patient, mantle zone growth pattern and a Ki-67 index < 10% suggest a favorable prognosis. A diagnosis of primary MCL in the thyroid remains rare and staging modalities as well as treatment options continue to evolve.

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“…The major sites of extranodal manifestations are blood, bone marrow, gastrointestinal tract, and lungs 2 . Notably, thyroid gland involvement is uncommonly reported, with only four case reports in the literature 3‐6 . Herein, we present two MCL patients with thyroid gland involvement on presentation.…”

Section: Introductionmentioning

confidence: 91%

“…2 Notably, thyroid gland involvement is uncommonly reported, with only four case reports in the literature. [3][4][5][6] Herein, we present two MCL patients with thyroid gland involvement on presentation.…”

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confidence: 99%