Mansonellosis, the most neglected human filariasis

Mediannikov, Oleg; Ranque, Stéphane

doi:10.1016/j.nmni.2018.08.016

Cited by 47 publications

(69 citation statements)

References 25 publications

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“…In endemic areas, the probability of infection increases with age, with the prevalence reaching 100% in highly endemic areas. However, the infection is the least studied and is likely one of the most neglected of all tropical diseases, subject to more neglect than schistosomiasis, taeniasis, echinococcosis, or rabies [9,10].…”

Section: Discussionmentioning

confidence: 99%

“…Like other neglected diseases, it mainly affects poor populations living in tropical and subtropical climates and it has not been associated with a clear and distinct clinical picture [1]. It can be considered one of the most neglected tropical infectious diseases [10].…”

Section: Discussionmentioning

confidence: 99%

“…In summary, the health-related impact on people living with these filariae remains unknown, and it can be considered one of the most neglected tropical infectious diseases [10]. Therefore, our study was aimed to describe the clinical patterns and treatment guidelines of imported M. pertans infection by migrants from Africa.…”

Section: Introductionmentioning

confidence: 99%

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Imported Mansonella Perstans Infection in Spain.

Puente¹,

Lago

Subirats

et al. 2020

Preprint

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Background: Mansonella perstans infection can be considered one of the most neglected tropical infectious diseases. Very few studies have reported on the clinical picture caused by infection with this nematode. Methods: The present study evaluated a large cohort of migrants who have been diagnosed, examined and treated for imported M. perstans infection at a Spanish reference center (Hospital Carlos III Tropical Medicine Unit, Madrid). Results: Five hundred three cases of migrants from tropical and subtropical areas with M. perstans infection were identified. Two hundred sixty-four patients were female (52.5%). The mean age (±SD) was 44.6±18.2 years (range, 16–93 years). The mean time (±SD) between the arrival in Spain and the first consultation was 8.618.0 months. The origin of the patients was Equatorial Guinea (97.6%). Regarding the clinical picture, 257 patients were asymptomatic (54.7%) and 228 were symptomatic (45.3%); 190 patients had pruritus (37.8%), 50 (9.9%) had arthralgia, 18 patients had Calabar-like swelling (3.6%), and 15 (3%) had abdominal pain. Four hundred forty-two (87.9%) migrants had hyper-IgE, and 340 (67.6%) had eosinophilia. One hundred ninety-five patients had coinfections with other filarial nematodes (38.8%), and 308 migrants had only M. perstans infection (61.2%). Four hundred thirty-seven cases (86.9%) had been treated with anti-filarial drugs: 292 cases were treated with one anti-filarial drug, and 145 cases were treated with combined anti-filarial therapy. No significant differences were found in the healing outcomes (p>0.05). Additionally, 20 (4%) cases received steroids and 38 (7.6%) cases received antihistamines. The combined anthelmintics and steroid treatment presented significantly better results (p=0.042); however, no significant results were noted for the combined anthelmintic and antihistamine treatment (p=0.191). No statistical association was found between the percentage of side effects to treatment and cases healed (p=0.094). Conclusions: A long series of M. perstans infections is presented in sub-Saharan immigrants whose data indicate that it should be included in the differential diagnosis in patients with pruritus or analytical alterations such as eosinophilia or hyper-IgE presentation, and they also have a high number of coinfections with other microorganisms whose treatment needs to be protocolized.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Imported Mansonella Perstans Infection in Spain.

Puente¹,

Lago

Subirats

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…In mammalian hosts, adult Mansonella worms are located in connective tissues or peritoneal, pleural, or pericardial cavities. 4 Microfilaria of M. perstans will circulate in the blood and are approximately 190 to 200 lm in length Â 4 lm (slightly smaller than the diameter of a red blood cell). The microfilariae are unsheathed; the tail tapers to a bluntly rounded end and nuclei extend to the end of the tail.…”

Section: Discussionmentioning

confidence: 99%

“…M. perstans is considered the most frequent filariasis in Africa. 4 It is found mostly in the wet and subtropical and tropical areas of Africa from Senegal to Zimbabwe. Despite accumulating evidence of a high prevalence in endemic areas, currently there is no filariasis control program targeting mansonellosis.…”

Section: Discussionmentioning

confidence: 99%