Mansonella ozzardi in Neotropical region of Argentina: Prevalence through time (1986–2010)

Aybar, Cecilia A. Veggiani; Juri, María Julia Dantur; Zaidenberg, Mario

doi:10.1016/j.actatropica.2015.09.018

Cited by 7 publications

(13 citation statements)

References 14 publications

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“…The highest prevalence rates in northwestern Argentina are currently found in sites covered by subtropical mountainous rainforest (Yungas), such as Tartagal and San Ramón de la Nueva Orán, both in Salta province, and Libertador General San Martín and San Pedro de Jujuy, both in Jujuy province. 44 This is consistent with previous studies in the provinces of Jujuy 62,63 and Salta. 64 The number of M. ozzardi infections diagnosed by microscopy has declined sharply in northwestern Argentina since 1986, when malaria transmission started to decrease and active case detection of malaria parasite carriers became less intensive.…”

Section: A Patchy Geographic Distributionsupporting

confidence: 83%

“…43 C. lahillei, Culicoides debilipalpis, and C. paraensis were recently described as the main vectors of M. ozzardi in northwestern Argentina and southwest Bolivia. 44 Interestingly, M. ozzardi microfilariae were also found to develop in the musculature of other experimentally infected dipterans, such as Anopheles aquasalis, Anopheles albitarsis, and Aedes aegypti. 45 The finding that vectors from different insect families are able to transmit M. ozzardi led to the hypothesis that highly divergent parasite populations with contrasting vector preference circulated in the Caribbean and the Amazon.…”

Section: 26mentioning

confidence: 99%

“…10,44,48,49,53,56,60,[65][66][67] There is also evidence that average microfilaria counts, among microscopy-positive subjects, increase with age, 48,68 consistent with increased exposure in adults leading to frequent superinfection in the absence of effective acquired immunity. Adult males are more often affected than females, 18,44,48,52 with greater average microfilaremias in males, 48 suggesting that the risk of infection may be associated with occupation-related exposure (e.g. subsistence farming and fishing).…”

Section: 6781mentioning

confidence: 99%

“…64 The number of M. ozzardi infections diagnosed by microscopy has declined sharply in northwestern Argentina since 1986, when malaria transmission started to decrease and active case detection of malaria parasite carriers became less intensive. 44 Despite the parasite's versatility regarding vector preference, M. ozzardi transmission is clearly focal. Many transmission hotspots in the Amazon Basin map to indigenous communities, such as the Ticuna on Solimões river, 10 the Apurinã on Purus river, 48 and other Amerindian villages in Brazil 49 and Venezuela.…”

Section: A Patchy Geographic Distributionmentioning

confidence: 99%

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Mansonella ozzardi: a neglected New World filarial nematode

Lima

Aybar

Juri

et al. 2016

Pathogens and Global Health

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Mansonella ozzardi (Nematoda: Onchocercidae) is an understudied filarial nematode, originally described by Patrick Manson in 1897, that can be transmitted by two families of dipteran vectors, biting midges (most of them members of the genus Culicoides) and black flies (genus Simulium). With a patchy geographic distribution from southern Mexico to northwestern Argentina, human infection with M. ozzardi is highly prevalent in some of the Caribbean islands, along riverine communities in the Amazon Basin, and on both sides of the border between Bolivia and Argentina. There is no clinical entity unequivocally associated with M. ozzardi infection, although fever, arthralgia, headache, cold lower extremities, and itchy cutaneous rashes are occasionally mentioned in case report series. More recently, ocular manifestations (especially keratitis) have been associated with mansonelliasis, opening an important area of investigation. Here, we briefly review the biology, epidemiology, pathogenesis, and clinical aspects of M. ozzardi infection and point to some existing knowledge gaps, aiming to stimulate a research agenda to help filling them. IntroductionMansonella ozzardi (Nematoda: Onchocercidae) is one of the several filarial nematodes that infect humans. This relatively unknown parasite has a patchy geographic distribution across Latin America and the Caribbean, from southern Mexico to northwestern Argentina. Most infected people, regardless of the parasite density, are asymptomatic or have few symptoms. As a consequence, infections with M. ozzardi usually remain undiagnosed and untreated. Ill-defined and unspecific symptoms such as fever, arthralgia, headache, cold lower extremities, and itchy cutaneous rashes are occasionally reported by patients, but whether they are caused by M. ozzardi infection remains to be determined. Nevertheless, ocular manifestations potentially associated with mansonelliasis, especially keratitis, have attracted substantial interest from ophthalmologists in recent years. Here, we summarize key biological, epidemiological, and clinical aspects of M. ozzardi infection. We explore recent developments in pathogenesis, laboratory diagnosis, and chemotherapy and discuss the potential public health impact of this highly prevalent but largely neglected New World parasite. Biological featuresThree filarial nematodes of the genus Mansonella are known to cause human mansonelliasis: Mansonella streptocerca, which is endemic to Africa; Mansonella perstans, which is commonly found in Africa but also occurs in South America; and M. ozzardi, which is found exclusively in the Americas and the Caribbean islands.1 Only humans appear to be naturally infected with M. ozzardi; African patas monkeys (Erythrocebus patas), but not chimpanzees, rhesus, capuchin, or squirrel monkeys, are susceptible to experimental infection with this nematode. 4 Several decades later, Orihel and Eberhard described the elusive adult male and female worms recovered from experimentally infected patas monkeys. 2Natural infection with M. ...

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Section: A Patchy Geographic Distributionsupporting

confidence: 83%

Section: 26mentioning

confidence: 99%

Section: 6781mentioning

confidence: 99%

Section: A Patchy Geographic Distributionmentioning

confidence: 99%

See 2 more Smart Citations

Mansonella ozzardi: a neglected New World filarial nematode

Lima

Aybar

Juri

et al. 2016

Pathogens and Global Health

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“…In the South, the focus straddling Southern Bolivia and Northern Argentina is still active, as illustred by recent publications [51][52][53][54].…”

Section: On the South American Continentmentioning

confidence: 88%

Review of Mansonella ozzardi and its Vectors in the Neotropical Region with Emphasis on the Current Situation in Haiti

Raccurt¹

2017

J Bacteriol Parasitol

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Mansonella ozzardi (Nematoda: Onchocercidae) is an understudied filarial nematode. This human parasite transmitted by two families of dipteran vectors, biting midges (most of them members of the genus Culicoides) and black flies (genus Simulium), is endemic to the Neotropic regions of the New World. With a patchy geographic distribution from southern Mexico to northwestern Argentina, human infection with M. ozzardi is highly prevalent in some of the Caribbean islands, along riverine communities in the Amazon Basin, and on both sides of the border between Bolivia and Argentina. Studies conducted in Haiti between 1974 and 1984 allowed the first complete description of adult worm and permitted to clarify the taxonomic position of this filarial species. In this paper, the author reports the known geographic distribution of M. ozzardi in neotropical regions of America and Caribbean, and focuses on the current situation in Haiti where this filariasis remains a completely neglected public health problem.

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Mansonella ozzardiand its vectors in the New World: an update with emphasis on the current situation in Haiti

Raccurt

2017

J. Helminthol.

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Mansonella ozzardi (Nematoda: Onchocercidae) is a little studied filarial nematode. This human parasite, transmitted by two families of dipteran vectors, biting midges (most of them members of the genus Culicoides) and blackflies (genus Simulium), is endemic to the Neotropical regions of the New World. With a patchy geographical distribution from southern Mexico to north-western Argentina, human infection with M. ozzardi is highly prevalent in some of the Caribbean islands, along riverine communities in the Amazon Basin, and on both sides of the border between Bolivia and Argentina. Studies conducted in Haiti between 1974 and 1984 allowed the first complete description of the adult worm and permitted clarification of the taxonomic position of this filarial species. This paper reports the known geographical distribution of M. ozzardi in Neotropical regions of the Americas, and focuses on the current situation in Haiti where this filariasis remains a completely neglected public health problem.

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Mansonella ozzardi in Neotropical region of Argentina: Prevalence through time (1986–2010)

Cited by 7 publications

References 14 publications

Mansonella ozzardi: a neglected New World filarial nematode

Mansonella ozzardi: a neglected New World filarial nematode

Review of Mansonella ozzardi and its Vectors in the Neotropical Region with Emphasis on the Current Situation in Haiti

Mansonella ozzardiand its vectors in the New World: an update with emphasis on the current situation in Haiti

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