Manool, a Salvia officinalis diterpene, induces selective cytotoxicity in cancer cells

Oliveira, Pollyanna Francielli de; Munari, Carla Carolina; Nicolella, Heloiza Diniz; Veneziani, Rodrigo Cássio Sola; Tavares, Denise Crispim

doi:10.1007/s10616-015-9927-0

Cited by 29 publications

(13 citation statements)

References 14 publications

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“…In vitro and in vivo studies reported that the SAL components such as caryophyllene, α-humulene, manool, ursolic acid, and rosmarinic acid had the potential to inhibit tumor cells growth in different cell lines, prevent skin tumors formation, impede angiogenesis phases such as proliferation, migration, adhesion and tube formation. 28,30,32,[36][37][38] One of the major side effects of IFO is nephrotoxicity that can be attributed to the formation of IFO CAA metabolite. As a consequence, glomerular toxicity may develop due to the increase in blood CRT concentration and the reduction of GFR.…”

Section: Discussionmentioning

confidence: 99%

Incorporating ifosfamide into salvia oil-based nanoemulsion diminishes its nephrotoxicity in mice inoculated with tumor

2019

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Introduction: Nephrotoxicity is one of the major side effects of the chemotherapeutic drug, ifosfamide (IFO). In this study, IFO was solubilized in nanoemulsion (NE) containing salvia (SAL) essential oil to investigate its adverse side effects in mice. Methods: One hundred female Swiss albino mice (n = 20/group) were split into five groups. Group I (Normal) received saline solution (0.9% (w/v) NaCl) while groups II-V were intraperitoneally (I.P.) injected with 2.5 × 106 Ehrlich ascetic carcinoma (EAC) cells/mouse. Group II (EAC) represented the untreated EAC-bearing mice. Group III (IFO) was treated with IFO at a dose of 60 mg/kg/d (I.P. 0.3 mL/mouse). Group IV (SAL) was treated with 0.3 mL blank NE-based SAL oil/mouse. Group V (SAL-IFO) was treated with IFO, loaded in 0.3 mL of blank SAL-NE, at a dose of 60 mg/kg/d (I.P. 0.3 mL/mouse). Groups III-V were treated for three consecutive days. Results: There was a double increase in the survival percentage of the SAL-IFO group (60%) relative to the IFO group (30%). Renal damage with the presence of Fanconi syndrome was indicated in the IFO group through a significant elevation in the levels of serum creatinine, blood urea nitrogen, urine bicarbonate, and phosphate in addition to a reduced level of glucose compared to the normal group. On the other hand, the administration of SAL-IFO into the mice reversed this effect. Additionally, the oxidative stress in the kidney tissues of the SAL-IFO group was ameliorated when compared to the IFO group. Conclusion: Incorporating IFO into SAL-NE has protected the kidneys from the damage induced by IFO.

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Section: Discussionmentioning

confidence: 99%

Incorporating ifosfamide into salvia oil-based nanoemulsion diminishes its nephrotoxicity in mice inoculated with tumor

2019

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“…11 Manool, a diterpene, induces selective cytotoxicity on human cervical adenocarcinoma and human glioblastoma. 34 Also, ursolic acid, a pentacyclic triterpenoid, inhibits angiogenesis, neoplastic proteases, and invasion of melanoma cells. 35 Among flavonoids of S. officinalis , rosmarinic acid has been extensively studied for its anticancer effects.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Pharmacological properties of Salvia officinalis and its components

Ghorbani

Esmaeilizadeh

2017

Journal of Traditional and Complementary Medicine

409

295

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Salvia officinalis (Sage) is a plant in the family of Labiatae/Lamiaceae. It is native to Middle East and Mediterranean areas, but today has been naturalized throughout the world. In folk medicine, S. officinalis has been used for the treatment of different kinds of disorders including seizure, ulcers, gout, rheumatism, inflammation, dizziness, tremor, paralysis, diarrhea, and hyperglycemia. In recent years, this plant has been a subject of intensive studies to document its traditional use and to find new biological effects. These studies have revealed a wide range of pharmacological activities for S. officinalis. Present review highlights the up-to-date information on the pharmacological findings that have been frequently reported for S. officinalis. These findings include anticancer, anti-inflammatory, antinociceptive, antioxidant, antimicrobial, antimutagenic, antidementia, hypoglycemic, and hypolipidemic effects. Also, chemical constituents responsible for pharmacological effects of S. officinalis and the clinical studies on this plant are presented and discussed.

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“…Compounds with promising therapeutic value must be able to selectively target cancer cells without affecting normal cells [37]. An anticancer agent is considered to have pharmacological or therapeutic activity if it has an SI value greater than or equal to 2 [38,39]. Compounds or drugs with SI values less than 2 are therefore considered toxic as they harm normal cells as much as or more than cancerous cells.…”

Section: Discussionmentioning

confidence: 99%

Antiproliferative Activities of Methanolic Extract and Fractions of Tetrapleura Tetraptera Fruit

Aikins

Birikorang

Chama

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Most of the current cancer chemotherapeutics are associated with harsh and undesirable side effects, including toxicity and chemoresistance, driving the need for safer and more effective alternatives. In this study, the antiproliferative activities of the methanolic extract of Tetrapleura tetraptera fruits and nine different fractions (C1–C9) from the column chromatographic separation of the extract against leukemia (Jurkat) and human breast cancer (MCF-7) cell lines were investigated using a tetrazolium-based colorimetric assay. Phytochemical screening of the extract and fractions found alkaloids, carbohydrates, flavonoids, glycosides, phenols, saponins, steroids, tannins, and terpenoids in the methanolic extract. Most of the fractions exhibited antiproliferative activity (>100 μg/mL) with the Jurkat cells being more susceptible than the MCF-7 cells. Four of the collected fractions C4, C3, C5, and C2 had good selective indices in decreasing order of activity, in the case of Jurkat cells. Liquid chromatography-mass spectrometry analysis of all samples (except for C4 and C9) revealed that C1, C2, C3, and C5 each had a single component. More importantly, fractions C2, C3, and C5, which were selective to Jurkat cells, also had the same retention time of 1.846 min. Fractions C6 and C8 had two components, with C7 having four components. This study serves as a basis for further work to isolate and characterize potential anticancer agents from the fractions of extracts of T. tetraptera fruits.

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Manool, a Salvia officinalis diterpene, induces selective cytotoxicity in cancer cells

Cited by 29 publications

References 14 publications

Incorporating ifosfamide into salvia oil-based nanoemulsion diminishes its nephrotoxicity in mice inoculated with tumor

Incorporating ifosfamide into salvia oil-based nanoemulsion diminishes its nephrotoxicity in mice inoculated with tumor

Pharmacological properties of Salvia officinalis and its components

Antiproliferative Activities of Methanolic Extract and Fractions of Tetrapleura Tetraptera Fruit

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