Manometrically jackhammer esophagus with fluoroscopically/endoscopically distal esophageal spasm: a case report

Sirinawasatien, Apichet; Sakulthongthawin, Pallop

doi:10.1186/s12876-021-01808-3

Cited by 4 publications

(3 citation statements)

References 16 publications

(21 reference statements)

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“…Thus, for patients with persistent GERD symptoms, prompt HREM and 24-hour pH impedance monitoring should be considered to evaluate PPIs effectiveness. Nifedipine is recognized as a potential therapeutic option for JE symptoms [13]. Several studies have shown Deanxit to be beneficial for JE patients with EGJ Outflow Obstruction (EGJOO) unresponsive to combined PPIs and nifedipine treatment [14].…”

Section: Discussionmentioning

confidence: 99%

A rare case of Jackhammer esophagus presenting with reflux-like symptoms in Guizhou, China

Yang,

Huang,

Chen

et al. 2023

Open J Clin Med Case Rep

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Jackhammer Esophagus (JE) is a rare esophageal motility disorder characterized by hyperdynamic contraction of the distal esophagus. High-Resolution Esophageal Manometry (HREM) remains the diagnostic benchmark. Clinically, JE manifests as dysphagia, chest pain, and symptoms suggestive of gastroesophageal reflux [1] often leading to misdiagnosis as Gastroesophageal Reflux Disease (GERD). Treatment approaches lack unified guidelines, with notable variability in outcomes. Initial management typically favors medical interventions [2]. This article examines the diagnostic and therapeutic journey of a JE case and provides insights into recent advancements in its diagnosis and management.

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Section: Discussionmentioning

confidence: 99%

A rare case of Jackhammer esophagus presenting with reflux-like symptoms in Guizhou, China

Yang,

Huang,

Chen

et al. 2023

Open J Clin Med Case Rep

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show abstract

“…When it comes to GERD, it might be of benefit to perform pH monitoring in those with predominantly typical or atypical reflux symptoms and to repeat HRM after anti-reflux treatment, as manometric findings may improve [ 1 - 2 , 7 , 9 , 11 ].…”

Section: Reviewmentioning

confidence: 99%

Distal Esophageal Spasm: An Updated Review

Zaher¹,

Patel²,

Atia³

et al. 2023

Cureus

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Distal esophageal spasm is characterized by premature contractions of the distal esophageal smooth muscle leading to non-obstructive dysphagia and non-cardiac chest pain. Diagnosis requires the presence of symptoms along with evidence of at least 20% premature contractions in the setting of a normal lower esophageal sphincter relaxation on high-resolution manometry. New updates to the Chicago Classification have improved the diagnostic accuracy of this method. Functional lumen imaging probe is a growing diagnostic modality that gives a more complete picture of esophageal motility. Pharmacologic treatment remains inadequate. Endoscopic myotomy might be of benefit for non-achalasia esophageal motility disorders. More research is required to better understand the pathophysiology and develop safe and long-lasting management for this disease.

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“…As there have not been any prospective studies addressing the treatment of HE, its management approach is yet to be validated. Pharmacotherapy including calcium channel blockers, nitrates, phosphodiesterase-5 inhibitors, anticholinergics, and low dose antidepressants is effective in a subset of patients with HE, but lacks longterm follow-ups to assess the efficacy of these drugs [14,15]. Interventional procedures such as botulinum toxin injection, pneumatic dilation and per-oral endoscopic myotomy (POEM) show favorable results when patients are refractory to medications [5,16,17].…”

Section: Case Presentationmentioning

confidence: 99%

Hypercontractile esophagus responsive to potassium-competitive acid blockers: a case report

et al. 2022

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Background Hypercontractile esophagus is a rare hypercontractile esophageal motility disorder. The etiology of hypercontractile esophagus is unknown but an association between acid reflux and hypercontractile esophagus has been suggested. We present the first report on the use of potassium-competitive acid blockers in the treatment of hypercontractile esophagus. Case presentation A 43-year-old man presented with dysphagia, chest pain and regurgitation for a period of 1 year. Initial workup showed a twisted lumen with abnormal contractions in the distal esophagus during upper gastrointestinal endoscopy and abnormal acid exposure under 24-h esophageal pH monitoring. The use of standard-dose proton pump inhibitors didn’t relieve his symptoms. Subsequent high-resolution esophageal manometry made a diagnosis of hypercontractile esophagus. Treatment with vonoprazan resulted in symptomatic resolution and abnormal contractions were no longer detected on follow-up high-resolution manometry. Conclusions Potassium-competitive acid blockers like vonoprazan offer an alternative therapeutic method for patients with hypercontractile esophagus who are refractory to proton pump inhibitor therapy. The use of potassium-competitive acid blockers in hypercontractile esophagus warrants further research and may provide evidence for an acid-related etiology of hypercontractile esophagus.

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Manometrically jackhammer esophagus with fluoroscopically/endoscopically distal esophageal spasm: a case report

Cited by 4 publications

References 16 publications

A rare case of Jackhammer esophagus presenting with reflux-like symptoms in Guizhou, China

A rare case of Jackhammer esophagus presenting with reflux-like symptoms in Guizhou, China

Distal Esophageal Spasm: An Updated Review

Hypercontractile esophagus responsive to potassium-competitive acid blockers: a case report

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