Mannosylerythritol lipids: dual inhibitory modes against Staphylococcus aureus through membrane-mediated apoptosis and biofilm disruption

Antibacterial Efficacy and Mechanism of Mannosylerythritol Lipids-A on Listeria monocytogenes

“…As we can see from Figure S1 , there was a significant inhibitory effect of MEL-A when the concentration reached 32 μg/mL, which was regarded as the MIC. This finding was in agreement with previous findings [ 23 ], showing the strong antibacterial activity of MEL-A. In addition, compared with the MIC of MELs against B. cereus [ 13 ], our results also indicated that the pure substance MEL-A had a better antibacterial effect than the mixture of MELs.…”

Contributions of Glycolipid Biosurfactants and Glycolipid-Modified Materials to Antimicrobial Strategy: A Review

“…So far, it has been reported that MELs have exhibited excellent sterilizing impact on foodborne bacteria and is expected to be a novel safe alternative to food preservative in food storage. Shu et al investigated the antibacterial efficacy of MELs against Bacillus cereus and Staphylococcus aureus and concluded the mode of action involved the disruption of the cell membrane, leakage of cellular contents, the collapse of the whole cytoskeleton as well as induced cell apoptosis [76,77]. Liu et al observed the same phenomenon in Listeria monocytogenes treated by MEL-A (32 µg/mL), and further transcriptome analysis demonstrated that the differentially expressed genes were enriched in the ABC transporter system, which verified the disorder of transmembrane protein played a key role in MELmediated cell death [78].…”

“…tritici (wheat powdery mildew fungi), Colletotrichum dematium (mulberry anthracnose fungi), Glomerella cingulata (strawberry anthracnose fungi), and Magnaporthe grisea (rice blast fungi), presumably owing to their inhibition to conidial germination, and anticipated the future application of MELs as novel agricultural chemical pesticides [79]. On the other hand, it is evident that MELs showed potent anti-biofilm activity against Staphylococcus aureus through attachment inhibition and biofilm dispersal, which was explained as the involvement of biosurfactants in microbial adhesion and desorption [77,80].…”

Antibacterial properties of glycosylated surfaces: variation of the glucosidal moiety and fatty acid conformation of grafted microbial glycolipids

“…13,14 Several reviews have been published on this topic since more than a decade, 15,16 while a number of recent studies has shown additional interesting properties like adjuvant effects with other antimicrobial compounds [17][18][19] or anti-biofilm properties. [20][21][22] On this basis, specific formulation in the field of, e.g., oral hygiene, were recently developed. 17,23 The anti-adhesive properties of biosurfactants against pathogenic organisms like E. faecalis, S. mutans or E. coli are particularly interesting, 16 although the general protocol to study anti-adhesion and anti-biofilm properties of biosurfactants only consider a surface dispersion of the compound, this making it particularly vulnerable to washing.…”