Mannose receptor-mediated gene transfer into macrophages using novel mannosylated cationic liposomes

Kawakami, Shigeru; Sato, Ayumi; Nishikawa, Makiya; Yamashita, Fumiyoshi; Hashida, Mitsuru

doi:10.1038/sj.gt.3301089

Cited by 245 publications

(198 citation statements)

References 29 publications

Supporting

Mentioning

191

Contrasting

Unclassified

Order By: Relevance

“…In the kidney, the mRNA expression level enhanced by the lipoplex was not reduced by GdCl 3 pretreatment. This does not correspond to the observation that the amount of TNF-␣ in the cytoplasmic fraction of the kidney following lipoplex 48 injection was reduced by pretreatment with GdCl 3 (Figure 3). Probably a significant amount of the TNF-␣ protein detected in the kidney is derived from other organs, such as the liver and spleen, upon stimulation with lipoplex.…”

Section: Figure 3 Proinflammatory Cytokines In the Cytoplasmic Fracticontrasting

confidence: 79%

“…9,10 Although this inhibitory effect was observed in both groups, GdCl 3 -pretreated mice showed significantly higher amounts of luciferase expression in the lung on days 3 and 5 compared with saline-pretreated mice. This suggests that pretreatment with GdCl 3 blocks cytokine production by the lipoplex and partly eliminates the refractory behavior to 48 Gene expression in the lung was examined 6 h after the second injection of lipoplex containing pCMV-Luc. The amount of gene expression was evaluated as described previously.…”

Section: Figure 3 Proinflammatory Cytokines In the Cytoplasmic Fractimentioning

confidence: 99%

“…The amount of gene expression was evaluated as described previously. 48 repeated injections. However, the transgene expression in GdCl 3 -pretreated mice was unable to completely return to control levels in spite of almost complete suppression of TNF-␣ and IL-12 production in serum.…”

Section: Figure 3 Proinflammatory Cytokines In the Cytoplasmic Fractimentioning

confidence: 99%

See 2 more Smart Citations

The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes

et al. 2002

Self Cite

View full text Add to dashboard Cite

Recent studies have demonstrated that intravenous administration of a plasmid DNA-cationic liposome complex (lipoplex) induced significant proinflammatory cytokine production in blood and inhibited transgene expression in pulmonary endothelial cells. In this study, we examined the effects of gadolinium chloride (GdCl 3 ) pretreatment on the biodistribution and induction of proinflammatory cytokine production and transgene expression after intravenous injection of a lipoplex in mice. GdCl 3 is known to transiently deplete liver Kupffer cells and spleen macrophages after intravenous administration. Intravenous administration of a lipoplex triggers high levels of proinflammatory cytokine production, such as TNF-␣, IFN-␥ and IL-12 in serum and

show abstract

Section: Figure 3 Proinflammatory Cytokines In the Cytoplasmic Fracticontrasting

confidence: 79%

Section: Figure 3 Proinflammatory Cytokines In the Cytoplasmic Fractimentioning

confidence: 99%

See 1 more Smart Citation

The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes

et al. 2002

Self Cite

View full text Add to dashboard Cite

show abstract

“…formamide (Man-C4-Chol), a galactosylated cholesterol derivative, to prepare mannosylated liposomes [179]. To deliver drugs into macrophage-and/or dendritic cell in various tissues, we investigated various administration routes including intravenous [179,[192][193][194][195][196][197], intraperitoneal [198][199][200][201], and intratracheal [202,203] administration.…”

Section: Development Of Mannosylated Liposomesmentioning

confidence: 99%

“…We investigated macrophage-and/or dendritic cell-selective delivery of nucleic acids using mannosylated cationic liposomes based on their physicochemical properties. Because it is not necessary to pass through fenestrae in the liver to reach Kupffer cells and liver endothelial cells, we prepared 200-nm-sized pDNA/mannosylated lipoplexes [192]. After intravenous administration in mice, the highest gene expression was observed in liver non-parenchymal cells including Kupffer cells and liver endothelial cells.…”

Section: Nucleic Acid Deliverymentioning

confidence: 99%

Glycosylation-mediated targeting of carriers

Kawakami

Hashida

2014

Journal of Controlled Release

View full text Add to dashboard Cite

For safe and effective therapy, drugs should be delivered selectively to their target tissues or cells at an optimal rate. Drug delivery system technology maximizes the therapeutic efficacy and minimizes unfavorable drug actions by controlling their distribution profiles. Ligand-receptor binding is a typical example of specific recognition mechanisms in the body; therefore, ligand-modified drug carriers have been developed for active targeting based on receptor-mediated endocytosis. Among the various ligands reported thus far, sugar recognition is a promising approach for active targeting because of their high affinity and expression. Glycosylation has been applied for both macromolecular and liposomal carriers for cell-selective drug targeting.Recently, the combination of ultrasound exposure and glycosylated bubble liposomes has been developed. In this review, recent advances of glycosylation-mediated targeted drug delivery systems are discussed.

show abstract

Novel Hyperbranched Glycomimetics Recognized by the Human Mannose Receptor: Quinic or Shikimic Acid Derivatives as Mannose Bioisosteres

et al. 2001

View full text Add to dashboard Cite

The mannose receptor mediates the internalization of a wide range of molecules or microorganisms in a pattern recognition manner. Therefore, it represents an attractive entry for specific drug, gene, or antigen delivery to macrophages and dendritic cells. In an attempt to design novel effective synthetic mannose receptor ligands, quinic and shikimic acid were selected as putative mannose mimics on the basis of X-ray crystallographic data from the related rat mannose-binding lectin. As the mannose receptor preferentially binds to molecules displaying several sugar residues, fluorescein-labeled cluster quinic and shikimic acid derivatives with valencies of two to eight were synthesized. Their mannose receptor mediated uptake was assayed on monocyte-derived human dendritic cells by cytofluorimetric analysis. Mannose-receptor specificity was further assessed by competitive inhibition assays with mannan, by confocal microscopy analysis, and by expression of the mannose receptor in transfected Cos-1 cells. Constructs derived from both quinic and shikimic acid were efficiently recognized by the mannose receptor with an optimum affinity for the molecules with a valency of four. As a result, commercially available quinic and shikimic acids appear as stable mannose bioisosteres, which should prove valuable tools for specific cell delivery.

show abstract

Mannose receptor-mediated gene transfer into macrophages using novel mannosylated cationic liposomes

Cited by 245 publications

References 29 publications

The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes

The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes

Glycosylation-mediated targeting of carriers

Novel Hyperbranched Glycomimetics Recognized by the Human Mannose Receptor: Quinic or Shikimic Acid Derivatives as Mannose Bioisosteres

Contact Info

Product

Resources

About