Mannose-mediated nanodelivery of methotrexate to macrophages augments rheumatoid arthritis therapy

Abstract

Inflammation targeted delivery of methotrexate using mannose-installed polymersomes (Man-PMTX) can repolarize macrophages from M1 type to M2 type and mitigate proinflammatory cytokines, leading to effectively augmented rheumatoid arthritis therapy.

Is receptor mediated active macrophage targeting of amphotericin B nanoformulations a promising approach?

“…high macrophage uptake confirmed the role of ligand active targeting in enabling augmented macrophage uptake, corroborated other reports on carbohydrate enabled mannose receptor mediated uptake. [40][41][42] Nevertheless, we confirmed the same by performing the mannose receptor blocking assay, aided by confocal microscopy. A significant reduction in uptake of the FITC-ACEM LIPOMER in mannose treated macrophages validated the mannose receptor mediated uptake facilitated by ACEM.…”

A dual dynamically cross-linked hydrogel promotes rheumatoid arthritis repair through ROS initiative regulation and microenvironment modulation-independent triptolide release

“…In recent years, many efforts have been made to develop sustained-release delivery routes, including microneedles [ 27 ], liposomes [ 28 ], nanoparticles [ 29 ] and hydrogels [ 30 ]. Yang et al [ 31 ] showed that mannose-modified polymer vesicles can be targeted and absorbed at RA lesion sites. Methotrexate was then slowly released to induce macrophage repolarization to M2 phenotype, thereby alleviating inflammation and preventing synovium damage.…”

Apoptotic extracellular vesicles restore homeostasis of the articular microenvironment for the treatment of rheumatoid arthritis

“…In addition, glucocorticoids may suppress the regenerative capacity of bone and cartilage tissue [ 6 ]. Recent approaches for RA treatment using anti-inflammatory nanoparticles [ 7 , 8 ] have been reported. However, their application is also limited because they were unable to stimulate the repair process in the joints.…”