Abstract:Butyrate is a key bacterial metabolite that plays an important and complex role in modulation of immunity and maintenance of epithelial barriers. Its translation to clinic has been limited by poor bioavailability, pungent smell, and the need for high doses, and effective delivery strategies have yet to realize clinical potential. Here we report a novel polymeric delivery platform for tunable and sustainable release of butyrate consisting of a methacrylamide backbone with butyryl ester or phenyl ester side chai… Show more
“…Materials such as these have often been employed to improve outcomes diabetic wound healing, including fibrous mats releasing pioglitazone hydrochloride, 365 stimuli-responsive materials releasing metformin, 366 or soluble polymeric materials releasing butyrate. 367…”
This review discusses the balance of inflammation in immunity and biomaterials strategies to modulate immunity in cases of imbalance such as autoimmune disease, infection, and cancer. Adapted from “Balanced Energy State”, by BioRender.com (2023).
“…Materials such as these have often been employed to improve outcomes diabetic wound healing, including fibrous mats releasing pioglitazone hydrochloride, 365 stimuli-responsive materials releasing metformin, 366 or soluble polymeric materials releasing butyrate. 367…”
This review discusses the balance of inflammation in immunity and biomaterials strategies to modulate immunity in cases of imbalance such as autoimmune disease, infection, and cancer. Adapted from “Balanced Energy State”, by BioRender.com (2023).
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