Mannose-binding lectin polymorphisms and rheumatoid arthritis: A short review and meta-analysis

Boschmann, Stefanie Epp; Goeldner, Isabela; Tuon, Felipe Francisco; Schiel, Wagner; Aoyama, Fernanda; Messias-Reason, Iara José de

doi:10.1016/j.molimm.2015.10.010

Cited by 13 publications

(7 citation statements)

References 68 publications

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“…However, the mixed ethnic population and limited sample size may make their results unreliable, or serious deviation from the real situation. Moreover, Stefanie et al 35 also conducted a meta-analysis and the results showed that MBL2 search had reported that there was no association found between rs1800450 and RA, which was contradictory with our findings. 43 It is normal that such distinct consequences were obtained in separated studies.…”

Section: Ta B L Econtrasting

confidence: 99%

“…However, the mixed ethnic population and limited sample size may make their results unreliable, or serious deviation from the real situation. Moreover, Stefanie et al 35 also conducted a meta‐analysis and the results showed that MBL2 low‐producing OO and XX genotypes do not confer higher risk to RA, even when data were analyzed according to the cohort's ethnicity. Due to the diversity of MBL2 alleles and divergent concepts about high and low‐producing genotypes, they analyzed first only exon 1 polymorphisms and classified the data according to the presence of AA, AO and OO genotypes.…”

Section: Discussionmentioning

confidence: 99%

“…Lastly, 15 articles that included insufficient data, 5 articles in which the control populations deviated from HWE and 18 reviews or meta-analysis researches about MBL gene polymorphisms were excluded. 25,32,[34][35][36][37][38][39][40][41][42][43][44] After filtering, 13 eligible studies involving 36 data sets were finally included. 8,[16][17][18][19][20]24,[45][46][47][48][49][50][51][52][53] controls were pooled to evaluate the relationship between SNPs of MBL and RA in the meta-analysis (Table 1).…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

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Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis

Chen

Yan

et al. 2021

Int J of Rheum Dis

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Background The effect of mannose‐binding lectin (MBL) gene polymorphisms on susceptibility of rheumatoid arthritis (RA) were evaluated in ethnically different populations, whereas the results were always inconsistent. Materials and methods Fourteen articles involving 36 datasets were recruited to evaluate the association between MBL gene polymorphisms and rheumatoid arthritis in a meta‐analysis. The random or fixed effect models were used to evaluate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). Results Stratified analysis by ethnicities was conducted and the result revealed that rs1800450 (T vs C, OR = 1.32, 95% CI: 1.04‐1.67, P < .05) and MBL‐A/O (T vs C, OR = 1.20, 95% CI: 1.08‐1.34, P < .001) were strongly associated with RA in Brazilian populations. In addition, the significant relationship between rs11003125 (T vs C, OR = 1.16, 95% CI: 1.06‐1.26, P < .05) with RA were also observed in East Asian populations. Meanwhile, the inverse associations between rs5030737 with RA in East Asians and rs1800450 with RA in Indians were acquired. However, no association between any MBL polymorphism with RA susceptibility was confirmed in Caucasians. Conclusions The structural polymorphisms in exon 1 of MBL gene may significantly contribute to susceptibility and development of RA in Brazilian and Indian populations, whereas the functional polymorphisms in the promoter region were more likely to associate with RA in East Asians.

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Section: Ta B L Econtrasting

confidence: 99%

“…However, the mixed ethnic population and limited sample size may make their results unreliable, or serious deviation from the real situation. Moreover, Stefanie et al 35 also conducted a meta‐analysis and the results showed that MBL2 low‐producing OO and XX genotypes do not confer higher risk to RA, even when data were analyzed according to the cohort's ethnicity. Due to the diversity of MBL2 alleles and divergent concepts about high and low‐producing genotypes, they analyzed first only exon 1 polymorphisms and classified the data according to the presence of AA, AO and OO genotypes.…”

Section: Discussionmentioning

confidence: 99%

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

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Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis

Chen

Yan

et al. 2021

Int J of Rheum Dis

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“…38 However, a recent meta-analysis found no association between MBL2 genotype and occurrence of rheumatoid arthritis. 39 Higher levels of lectin pathway proteins were recently demonstrated in SLE patients, 40 and ficolin-1 was associated with disease severity in SLE. 41 More recently, the lectin pathway has also been associated with metabolic diseases with inflammatory components, such as diabetes 42,43 and atherosclerosis, 44,45 and some studies also reported increased levels of serum MBL in cancer.…”

Section: Associations Between Lectin Pathway Protein Levels and Diseasementioning

confidence: 94%

The Lectin Pathway in Thrombotic Conditions—A Systematic Review

Larsen

Hvas

2018

Thromb Haemost

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The lectin pathway of the complement system can activate the coagulation system in vitro, but the role of the lectin pathway in haemostatic activation and thrombosis in vivo is not clear. We performed a systematic review of the existing literature on associations between the lectin pathway and arterial and venous thrombosis, in accordance with the Assessing the Methodological Quality of Systematic Reviews guidelines. PubMed and Embase were searched from January 1990 to March 2017. We included original studies on human study populations investigating associations between the lectin pathway (protein serum levels, genotype or gene expression) and thrombotic conditions or laboratory coagulation markers. Exclusion criteria were case studies including fewer than five cases, conference abstracts or any other language than English. In total, 43 studies were included which investigated associations between the lectin pathway and cardiovascular thrombotic events (CVEs) ( = 22), ischaemic stroke ( = 9), CVE and stroke ( = 1) and other conditions (systemic lupus erythematosus [ = 6], sepsis-related coagulopathy [ = 3], pulmonary embolism [ = 1], asparaginase treatment [ = 1]). Studies on the lectin pathway and CVE risk reported discrepant results, as both high and low mannose-binding lectin (MBL) serum levels were found to correlate with increased CVE risk. In ischaemic stroke patients, occurrence of stroke as well as increased stroke severity and poor outcome were consistently associated with high serum MBL. For other thromboembolic conditions, only few studies were identified. In conclusion, lectin pathway activation may negatively influence outcome after ischaemic stroke and possibly contribute to CVE risk. Further research is warranted to elucidate the role of the lectin pathway in other thrombotic conditions.

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“…In the context of RA, there are several studies with conflicting results relating serum levels of MBL and its genetic polymorphism with susceptibility, severity, radiographic progression and disease activity [ 3 , 5 , 8 , [15] , [16] , [17] , [18] ]. Reports on the role of MBL in RA involved in atherogenesis are also diverse.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular risk and mannose binding lectin in patients with rheumatoid arthritis from southern Brazil

Kahlow

Nisihara

Petisco

et al. 2018

IJC Heart & Vasculature

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BackgroundMannose binding lectin (MBL) appears to be involved in susceptibility to rheumatoid arthritis (RA), in the inflammatory process and in the genesis of atherosclerotic disease.ObjectiveTo study the association of MBL serum levels and its genotypic variation with carotid arteries intimal thickness (IMT) in RA patients from Southern Brazil.MethodsMBL serum levels, MBL2 genotyping and IMT were investigated in 90 RA patients along with their demographic, clinical and laboratory profile. MBL levels and MBL2 genotyping were evaluated in 90 healthy controls.ResultsA significant lower MBL serum concentration was observed in patients with RA in relation to controls (528 ng/mL vs 937.5 ng/mL, p = 0.05, respectively). The median IMT in RA patients was 0.59 mm (0.51 to 0.85 mm). There was no correlation between levels of MBL with disease activity, erythrocyte sedimentation rate, autoantibodies presence or IMT (p = NS). A weak and negative correlation was found between MBL and CRP levels (Rho = −0.24; p = 0.02;). The MBL2 variant at codon 54 (variant B) and HYPA haplotype were the most frequently observed in the RA sample (67.5% and 31.7%). MBL2 wild type (A/A) were associated with lower IMT when compared with heterozygotes (A/O; p = 0.04) and low producers (O/O; p = 0.05). In addition, high producers genotypes had lower levels of CRP when compared with medium (p = 0.04) or with low producers (p = 0.05).ConclusionRA patients had lower MBL levels than controls. MBL were negatively associated with CRP serum levels; low MBL genotypes producers increased thickness of the IMT than high producers.

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Mannose-binding lectin polymorphisms and rheumatoid arthritis: A short review and meta-analysis

Cited by 13 publications

References 68 publications

Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis

Effect of mannose‐binding lectin gene polymorphisms on the risk of rheumatoid arthritis: Evidence from a meta‐analysis

The Lectin Pathway in Thrombotic Conditions—A Systematic Review

Cardiovascular risk and mannose binding lectin in patients with rheumatoid arthritis from southern Brazil

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