Mannose-binding Lectin Expression Genotype in Pediatric-onset Systemic Lupus Erythematosus: Associations with Susceptibility to Renal Disease and Protection Against Infections

Tsai, Yao-Te; Yeh, Kou-Wei; Yao, Tsung‐Chieh; Huang, Yuguang; Kuo, Ming‐Ling; Huang, Jing-Long

doi:10.3899/jrheum.100961

Cited by 10 publications

(16 citation statements)

References 34 publications

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“…A Japanese study of 147 adult patients did not conclusively demonstrate an association between MBL levels and disease activity, although serum MBL concentration did show significant association with serum C3 or CH 50 levels [25]. Our study of 93 patients with lupus and 67 controls showed elevated plasma MBL in SLE compared to healthy controls corroborating the observations made in previous studies [14-16]. Interestingly, SLE patients also displayed higher plasma MBL levels compared to healthy controls with similar MBL2 genetic background [25].…”

Section: Discussionsupporting

confidence: 87%

“…A study on Taiwanese pediatric SLE patients showed a positive correlation. In addition, plasma MBL also correlated positively with anti-dsDNA but not with complement factors (C3 and C4) [14]. A Japanese study of 147 adult patients did not conclusively demonstrate an association between MBL levels and disease activity, although serum MBL concentration did show significant association with serum C3 or CH 50 levels [25].…”

Section: Discussionmentioning

confidence: 99%

“…Higher plasma MBL levels in SLE patients have been reported in various populations [14-16]. MBL appears to have a dual mode of action: increased MBL leads to enhanced complement activation and tissue damage, while its deficiency has been linked with defective clearance of apoptotic cells that provide a stimulus for autoantibody formation [17].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, we have observed predisposition of patients with low MBL-producing genotype (LXA/LYB, LYB/LYB and LXB/LXB) to develop SLE and autoimmune hemolytic anemia (AIHA) [24]. Literature is limited on the association of MBL with disease activity [14,25]. The current study investigates the association between plasma MBL levels and SLE disease activity in a cohort of female patients from Eastern India.…”

Section: Introductionmentioning

confidence: 99%

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Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity

et al. 2012

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IntroductionA role for mannose binding lectin (MBL) in autoimmune diseases has been demonstrated earlier and elevated level of MBL has been shown in systemic lupus erythematosus (SLE) patients. In the current study, we investigated MBL as a potential biomarker for disease activity in SLE.MethodsIn a case control study SLE patients (93 females) and 67 age, sex, ethnicity matched healthy controls were enrolled. Plasma MBL levels were quantified by enzyme linked immunosorbent assay (ELISA). Clinical, serological and other markers of disease activity (C3, C4 and anti-dsDNA) were measured by standard laboratory procedures.ResultsPlasma MBL levels were significantly high in SLE patients compared to healthy controls (P < 0.0001). MBL levels were variable in different clinical categories of SLE. Lower levels were associated with musculoskeletal and cutaneous manifestations (P = 0.002), while higher and intermediate MBL levels were significantly associated with nephritis in combination with other systemic manifestations (P = 0.01 and P = 0.04 respectively). Plasma MBL correlated with systemic lupus erythematosus disease activity index (SLEDAI) (P = 0.0003, r = 0.36), anti-dsDNA (P < 0.0001, r = 0.54), proteinuria (P < 0.0001, r = 0.42) and negatively correlated with C3 (P = 0.007, r = -0.27) and C4 (P = 0.01, r = -0.29).ConclusionsPlasma MBL is a promising marker in the assessment of SLE disease activity.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity

et al. 2012

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“…Age 18 years is the threshold age at diagnosis with SLE that is most frequently used to define SLE with onset during childhood or adolescence in population‐based research around the world (2, 4, 22–49). Nevertheless, age cutoffs used in studies of SLE range from 14–21 years (50–67). This is in line with some studies comparing pediatric versus adult populations with other chronic diseases, including asthma (68) and type 2 diabetes mellitus (69), which consider threshold ages of up to 20 years at diagnosis to define the pediatric subgroup.…”

Section: When Does Adulthood Start?mentioning

confidence: 99%

Taxonomy for systemic lupus erythematosus with onset before adulthood

Silva¹,

Avčin²,

Brunner³

2012

Arthritis Care & Research

162

116

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Objective To propose a common nomenclature to refer to individuals who fulfill the American College of Rheumatology Classification Criteria for systemic lupus erythematosus (SLE) during childhood or adolescence. Methods The medical literature was reviewed for studies conducted in the target population between 1960 and December of 2011 to obtain information about the terms used to refer to such children and adolescents. We reviewed the threshold ages used and disease features considered to discriminate these individuals from patients with onset of SLE during adulthood. Furthermore, the nomenclature used in other chronic diseases with onset during both childhood and adulthood was assessed. Results There was an astonishing variability in the age cut-offs used to define SLE-onset prior to adulthood, ranging from 14 to 21 years but most studies used 18 years of age. The principal synonyms in the medical literature were SLE without reference to the age at onset of disease, childhood-onset SLE, juvenile SLE, and pediatric (or paediatric) SLE. Conclusions Based on the definition of childhood, in analogy with other complex chronic disease commencing prior to adulthood, and given the current absence of definite genetic variations that discriminate adults from children, the term childhood-onset SLE is proposed when referring to individuals with onset of SLE prior to age 18 years.

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Vaccine-preventable infections in Systemic Lupus Erythematosus

Murdaca

Orsi

Spanò

et al. 2016

Human Vaccines & Immunotherapeutics

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Systemic Lupus Erythematosus (SLE) is characterized by abnormal autoantibody production and clearance. Infections are among the most important causes of morbidity and mortality in SLE patients; they have an increased frequency of severe bacterial and viral infections possibly due to inherited genetic and immunologic defects and to immunosuppressive therapies. In addition, infectious agents can switch on lupus disease expression and activity. Among the strategies to reduce the risk of infection, vaccination can be considered the most reliable option. Most vaccines are effective and safe in SLE patients, although in certain cases immunogenicity may be sub-optimal and vaccination can trigger a flare. Although these issues are currently unresolved, the risk benefit balance is in favor for vaccination to reduce the risk of infection in SLE patients. In the present review we discuss the preventive strategies currently recommended to reduce bacterial and viral infections in SLE.

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Mannose-binding Lectin Expression Genotype in Pediatric-onset Systemic Lupus Erythematosus: Associations with Susceptibility to Renal Disease and Protection Against Infections

Abstract: Our findings suggest that a high MBL expression genotype is a risk factor for renal disorder, while it has a protective effect against infections. Serum MBL levels reflect SLE activity.

Cited by 10 publications

References 34 publications

Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity

Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity

Taxonomy for systemic lupus erythematosus with onset before adulthood

Vaccine-preventable infections in Systemic Lupus Erythematosus

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