2024
DOI: 10.1371/journal.pone.0298729
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Mannose and glycine: Metabolites with potentially causal implications in chronic kidney disease pathogenesis

Yongzheng Hu,
Wei Jiang

Abstract: Background Chronic Kidney Disease (CKD) represents a global health challenge, with its etiology and underlying mechanisms yet to be fully elucidated. Integrating genomics with metabolomics can offer insights into the putatively causal relationships between serum metabolites and CKD. Methods Utilizing bidirectional Mendelian Randomization (MR), we assessed the putatively causal associations between 486 serum metabolites and CKD. Genetic data for these metabolites were sourced from comprehensive genome-wide as… Show more

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