Mannitol Delivery by Vibrating Mesh Nebulisation for Enhancing Mucociliary Clearance

Delivery of High Solubility Polyols by Vibrating Mesh Nebulizer to Enhance Mucociliary Clearance

“…In this previous study (10) it was found that a similar dose of mannitol could be delivered by nebulization, in a comparable or shorter time than required for delivery of the equivalent dry powder form. The provision being that coformulation with an electrolyte such as sodium chloride was necessary to achieve practical treatment times and realistic respirable aerosol fraction (defined as the percentage of aerosol < 5 lm).…”

“…The chemical information and osmotic equivalence among the three polyols is presented in Tables 1 and 2, (19)(20)(21) respectively. Based on data from a previous publication, (10) 1% saline was chosen as the vehicle for the polyol formulations. This concentration was proposed to impart an appropriate electrolyte concentration for realizing a practical treatment time without compromizing taste tolerability.…”

“…Fresh deionized water (MilliQ, Molsheim, France), sodium chloride (Batch 232931, LabServÔ, Clayton, Victoria, Australia), mannitol (Batch E236A, Roquette Frères, Lestrem, France), sorbitol (Batch 603650; Unilab, Ajax Chemicals, Auburn, Australia), and xylitol (Batch 744229, Roquette Frères, Lestrem, France) were used as supplied, to prepare the following fluids (in 1% w/v saline) for nebulization: (1) Mannitol (75 and 150 mg/mL), for comparison with the previous study by Chan et al (2011); 10 (2) Sorbitol (75, 150, 300, and 400 mg/mL); (3) Xylitol at osmotic concentrations equivalent to those for sorbitol (63, 125, 251, and 334 mg/mL, respectively). The chemical information and osmotic equivalence among the three polyols is presented in Tables 1 and 2, (19)(20)(21) respectively.…”

“…(1,9) Further, efficacious delivery is dependent on the patient's ability to inhale at a satisfactorily high flow rate, (7) which is not always achievable by the target nebulized mucoactive agent using vibrating mesh nebulizers as an alternative. (10) These modern devices deliver therapeutic agents much quicker and more efficiently than traditional jet nebulizers. (11)(12)(13) As CF patients generally require nebulization for delivery of various medications, it would further allow consolidation of therapy via a single mesh nebulizer device as opposed to a separate dry powder inhaler.…”

Physicochemical Characterization of Nebulized Superparamagnetic Iron Oxide Nanoparticles (SPIONs)

“…Several studies have highlighted the advantages of using mannitol in aerosolized therapeutics formulations. (30,31) The desirability of using nebulized mannitol is largely a result of its minimal airway transepithelial permeability, resulting in a longer duration of therapeutic action, as well as its pleasant taste and mouth feel for encouraging patient use. (32,33) Aerosolized Rienso particles were also captured on a TEM grid and analyzed to compare with the Rienso particles in the suspension.…”