“…The most frequently used method for the synthesis of 1-( N -acylamino)alkyl sulfones 3 , pioneered by Engberts and Strating in 1964, consists of three-component condensation of primary amides, carbamates, or carbamides ( 1 , R 1 = R, OR, or NHR, respectively) with aldehydes 2 and sodium sulfinates (Scheme ). − O - or S -Thiocarbamates, dithiocarbamates, or thiocarbamides have also been applied in a similar reaction. , Other methods for synthesizing these compounds, such as oxidation of the corresponding sulfides with H 2 O 2 , KMnO 4 , or m CPBA, − the Curtius-type rearrangement of α-sulfonylacyl azides, and substitution of the chlorine anion in N -(1-chloroalkyl)amides with p -toluenesulfinic acid, have found only limited application . The structural diversity of 1-( N -acylamino)alkyl sulfones synthesized using the Engberts and Strating method is confined by the limited availability of structurally diverse aldehydes 2 .…”