Mannich Bases of 2-Substituted Benzimidazoles – A Review

Abstract

Mannich bases are the end products of mannich reaction and are known as beta amino ketone carrying compounds. Mannich reaction is a carbon carbon bond forming nucleophilic addition reaction which helps in synthesizing N-methyl derivatives and many other drug molecules. Mannich base derivatives of benzimidazoles possess many pharmacological properties such as anti-oxidant, anti-inflammatory, anticancer, antiviral, anthelmintic and play an important role in medical field. As these drugs are clinically useful in treatment of microbial infections and exhibit other therapeutic activities also, so this encouraged the development of more potent, novel and clinically significant compounds. In this review synthesis and various biological activities of new mannich bases of benzimidazole derivatives reported is discussed.

Therapeutic Potential of Schiff and Mannich Bases of 2-Substituted Benzimidazole Analogues

“…Amino alkyl side chain in mannich bases act as a vital bioactive scaffold for designing inestimable required drugs of potent therapeutic significance. 13 Ranitidine, Atropine, Cocaine are remarkable mannich bases incorporating amino alkyl side chains. In synthetic pharmaceutical chemistry, dynamic role has been accredited by mannich bases.…”

“…Sequence of neoteric sequence of pyrazolo-benzimidazole hybrid mannich bases (Figure 10) were scrutinized and characterized by IR, 13 C-NMR, 1 H-NMR and elemental analysis. 23 Series of compounds were analyzed against various gram +ve and gram-ve strains.…”

“…Derivatives showed inhibitory effects on microtubules. Likewise, newfangled benzimidazole mannich bases (13) as strong anti-tubercular and anti-protozoal agents were examined (Figure 15). These novel benzimidazole scaffolds showed excellent potency against T. cruzi and L. mexicana.…”