Mannich bases in polymer chemistry

Tramontini, M.; Angiolini, Luigi; Ghedini, Nadia

doi:10.1016/0032-3861(88)90132-2

Cited by 96 publications

(74 citation statements)

References 27 publications

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“…They are also used in polymer industry as paints and surface active reagents 19 . Mannich reaction is a three-component condensation reaction involving an active hydrogen containing compound, formaldehyde and a secondary amine.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, antiproliferative and antimicrobial activity of new Mannich bases bearing 1,2,4-triazole moiety

Popiołek

Rzymowska

Kosikowska

et al. 2014

Journal of Enzyme Inhibition and Medicinal Chemistry

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This study presents the synthesis, antiproliferative and antimicrobial evaluation of a new series of Mannich base derivatives containing 1,2,4-triazole system. New compounds were prepared by the reaction of 4,5-disubstituted 1,2,4-triazole-3-thiones with formaldehyde and various amines. The structures of the prepared compounds were confirmed by means of 1 H NMR, 13 C NMR and elemental analyses. Twelve compounds were evaluated for their in vitro antiproliferative activities against six chosen cancer cell lines. All synthesized compounds were screened for their in vitro antimicrobial activity by using the agar dilution technique. For 17 potentially active compounds, their antibacterial activity was confirmed on the basis of MIC (minimal inhibitory concentration) by broth microdilution method using the reference Grampositive and Gram-negative bacterial strains.

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Section: Introductionmentioning

confidence: 99%

Synthesis, antiproliferative and antimicrobial activity of new Mannich bases bearing 1,2,4-triazole moiety

Popiołek

Rzymowska

Kosikowska

et al. 2014

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…But oximes have other applications such as using oximes at heterocyclic compounds synthesis and also active esters hydrolysis by oxime protected polymers that depend on macro molecule characterizes. However, oximes, have different spatial chemistry depended on the reaction kind [19][20][21] , that the structures spatial chemistry quality is effective at productions formation amount.…”

Section: Introductionmentioning

confidence: 99%

Study of 2-(piperidine-1-ylmethyl)cyclohexanamine Structure Synthesis Based on Oxime Protected Compounds in Mannich Mechanism

Taheri¹,

Soleymani²,

Hosn³

et al. 2012

Orientjchem.

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ABSTRACT2-(piperidine-1-ylmethyl)cyclohexanone (PMC), 2-(piperidine-1-ylmethyl)cyclohexanone oxime (PMCO) structures and also 2-(piperidine-1-ylmethyl) cyclohexan amine (PMCA) structure were extracted using experimental methods of Mannich reaction, based on oxime protected compounds. The given structures were purified at the end of syntheses process, by chromatography column. Related structures were identified by using 13 C-NMR, 1 H-NMR, FT-IR and mass spectroscopy. Attained results showed that using oxime structure as an intermediate causes to increase the yield and also to increase reaction ratio attain final product. However, all the attained spectra approved existence of intermediate and the final product. In following, thermodynamic parameters for the products including energetic levels, HOMO and LUMO parameters, chemical hardness, electrophilicity and chemical potential for this structures were calculated by using the density functional theory in method and B3LYP/6-311G(d,p) level of theory.

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“…The versatile utility of Mannich bases in polymers 14 , dispersants 15 and pharmaceutical chemistry 16 prompted us to prepare aminomethyl derivatives and evaluate their biological significance. Here we reports antibacterial activity of Mannich bases of 2-amino-9 [{(1,3 di hydroxyl propane-2yl) oxy} methyl] 6-9 dihydro-3H-purin-6-one including sulphonamide and secondary amines and their comparative study (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and in-Vitro Study of Some Medicinally Important Mannich Bases Derived From 2-Amino-9 [{(1, 3 Dihydroxy Propane-2yl) Oxy} Methyl] 6-9 Dihydro-3h-Purin-6-One

Joshi

Bilgaiyan

Pathak

2012

J. Chil. Chem. Soc.

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A series of biologically active Mannich bases with heteroaromatic ring system have been synthesized employing Mannich reaction of 2-amino-9 [{(1,3 dihydroxy propane-2yl) oxy}methyl] 6-9 dihydro-3H-purin-6-one ( potent drug) with biologically active sulphonamides and secondary amines. They were analyzed by elemental analysis and characterized by spectral studies-UV, IR, 1 H NMR, Powder X-ray diffraction and Scanning Electron Microscopy. The Mannich bases were screened for their antibacterial activity against various gram + and gram -bacteria. The results had shown that the Mannich bases are quiet active against pathogens under study at varying concentrations. The toxicity of synthesized Mannich bases was ascertained by LD 50 test.

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Mannich bases in polymer chemistry

Cited by 96 publications

References 27 publications

Synthesis, antiproliferative and antimicrobial activity of new Mannich bases bearing 1,2,4-triazole moiety

Synthesis, antiproliferative and antimicrobial activity of new Mannich bases bearing 1,2,4-triazole moiety

Study of 2-(piperidine-1-ylmethyl)cyclohexanamine Structure Synthesis Based on Oxime Protected Compounds in Mannich Mechanism

Synthesis and in-Vitro Study of Some Medicinally Important Mannich Bases Derived From 2-Amino-9 [{(1, 3 Dihydroxy Propane-2yl) Oxy} Methyl] 6-9 Dihydro-3h-Purin-6-One

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