Mannan and anti-CD40 antibody decorated and tumor antigen, CpG and Poly I:C encapsulated poly lactic-co- glycolic acid (PLGA) nanoparticles loaded dendritic cells induced type I immune responses against prostate cancer ex vivo
Negin Ziamiavaghi,
Nowruz Delirezh,
Sanaz Sheikhzadeh
Abstract:Purpose
Cancer vaccines that stimulate the immune system to detect tumor-related antigens and trigger a T cell response have shown remarkable success in prostate cancer immunotherapy. In this study, we used PLGA nanoparticles and a carrier to deliver TCL, CPG-ODN, and Poly I:C to dendritic cells. We engineered the surface of the nanoparticles with mannan and anti-CD40 antibodies to specialize TCL delivery to dendric cells. We estimated different molecules and adjuvants' effects on DCs and T cell activation.
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