Manipulation of Physiological Processes for Pharmaceutical Product Development

Maheshwari, Rahul; Kuche, Kaushik; Mane, Ankita; Chourasiya, Yashu; Tekade, Muktika; Tekade, Rakesh K.

doi:10.1016/b978-0-12-814423-7.00020-4

Cited by 9 publications

(4 citation statements)

References 78 publications

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“…The DNE Opt was able to release the drug faster compared to CNE Opt due to a lower degree of ionization in the CCM compared to DTX when tested at pH 6.5 and 7.4. According to the passive diffusion barrier concept, the drug in nonionized form could passively be diffused through the barriers effectively [ 44 ]. In contrast, the drug at a high degree of ionization state was deemed to be difficult in passing through the membranes, as it carried charge [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

Modeling the Effect of Composition on Formation of Aerosolized Nanoemulsion System Encapsulating Docetaxel and Curcumin Using D-Optimal Mixture Experimental Design

Asmawi

Salim

Abdulmalek

et al. 2020

IJMS

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The synergistic anticancer effect of docetaxel (DTX) and curcumin (CCM) has emerged as an attractive therapeutic candidate for lung cancer treatment. However, the lack of optimal bioavailability because of high toxicity, low stability, and poor solubility has limited their clinical success. Given this, an aerosolized nanoemulsion system for pulmonary delivery is recommended to mitigate these drawbacks. In this study, DTX- and CCM-loaded nanoemulsions were optimized using the D-optimal mixture experimental design (MED). The effect of nanoemulsion compositions towards two response variables, namely, particle size and aerosol size, was studied. The optimized formulations for both DTX- and CCM-loaded nanoemulsions were determined, and their physicochemical and aerodynamic properties were evaluated as well. The MED models achieved the optimum formulation for DTX- and CCM-loaded nanoemulsions containing a 6.0 wt% mixture of palm kernel oil ester (PKOE) and safflower seed oils (1:1), 2.5 wt% of lecithin, 2.0 wt% mixture of Tween 85 and Span 85 (9:1), and 2.5 wt% of glycerol in the aqueous phase. The actual values of the optimized formulations were in line with the predicted values obtained from the MED, and they exhibited desirable attributes of physicochemical and aerodynamic properties for inhalation therapy. Thus, the optimized formulations have potential use as a drug delivery system for a pulmonary application.

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Section: Resultsmentioning

confidence: 99%

Modeling the Effect of Composition on Formation of Aerosolized Nanoemulsion System Encapsulating Docetaxel and Curcumin Using D-Optimal Mixture Experimental Design

Asmawi

Salim

Abdulmalek

et al. 2020

IJMS

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“…Furthermore, first-pass hepatic metabolism is a major issue associated with the reduced gastrointestinal bioavailability of ICG 13 . In this sense, sublingual administration is promising as the sublingual space has low membrane thickness and keratinization 18 , potentially fostering systemic absorption when compared to other gastrointestinal membranes, and assisting bypassing first-pass metabolism 40 . Another valid approach to circumvent the aforementioned limitations is employing controlled release systems that are capable of sustaining drug release for a prolonged period of time.…”

Section: Discussionmentioning

confidence: 99%

Sublingual indocyanine green films for non-invasive swallowing assessment and inflammation detection through NIR/SWIR optical imaging

Beringhs

Singh

Valdez

et al. 2020

Sci Rep

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Indocyanine green (ICG) is the most commonly used FDA-approved agent for clinical optical imaging, administered through injections only, due to its poor membrane permeability. Although ICG has vast potential for non-invasive non-radioactive imaging in patients, the clinical applications are limited by the invasive administration and short half-life in blood circulation. To expand the clinical value of ICG, non-toxic chitosan-based ICG-loaded films were designed for sublingual administration for near-infrared (NIR) and short-wave infrared (SWIR) optical imaging. Two film formulations were developed with different ICG release rates. Mold-casted self-emulsifying films rapidly released ICG (80% in 4 h) in the form of nanosized droplets, which were mostly swallowed and produced significant contrast of upper digestive tract to enable in vivo swallowing evaluations using NIR/SWIR imaging. Regular films released ICG slowly (80% in 25 h), allowing for steady absorption of ICG to systemic circulation. Inflammation in mouse feet was detected within 30 min after sublingual administration with a 1.43-fold fluorescence increase within 1 h at the inflammation sites, comparable to a 1.76-fold increase through intravenous injection. Administering ICG using sublingual films displayed notable potential for non-invasive diagnosis and monitoring of inflammatory conditions and swallowing disorders, addressing a current need for alternatives to ICG parenteral administration.

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“…[ 66 ] As key organs of the MPS, the liver and spleen contain macrophages (Kupffer cells and splenic macrophages, respectively), which seem to play a major role in phage degradation, with the initial phagocytic activity of Kupffer cells in the liver being more effective than splenic macrophages at inactivating phage. [ 58,70 ] Phage inactivation by the liver and spleen are observed to differ, with phage degradation occurring at a slower rate in the spleen. [ 53,58,63 ] Longer half‐lives of phage in spleen compared to the liver and recovery of intact phage up to 7 days post‐injection from the spleen also indicate that the spleen acts as a “phage sink.” [ 53,63 ] The spleen may have an additional relevant role in phage therapy, via a nondestructive mechanism of capturing and retaining phage for antigen presentation, promoted by Schweigger–Seidel reticulum cells, thereby facilitating an adaptive immune response to produce phage‐neutralizing antibodies.…”

Section: Phage Biodistributionmentioning

confidence: 99%

Pharmacokinetics and Biodistribution of Phages and their Current Applications in Antimicrobial Therapy

Kang,

Bagchi,

Chen

2023

Advanced Therapeutics

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Antimicrobial resistance remains a critical global health concern, necessitating the investigation of alternative therapeutic approaches. With the diminished efficacy of conventional small molecule drugs due to the emergence of highly resilient bacterial strains, there is growing interest in the potential for alternative therapeutic modalities. As naturally occurring viruses of bacteria, bacteriophage (or phage) are being re‐envisioned as a platform to engineer properties that can be tailored to target specific bacterial strains and employ diverse antibacterial mechanisms. However, limited understanding of key pharmacological properties of phage is a major challenge to translating its use from preclinical to clinical settings. Here, this work reviews modern advancements in phage‐based antimicrobial therapy and discusses the in vivo pharmacokinetics and biodistribution of phage, addressing critical challenges in their application that must be overcome for successful clinical implementation.

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Manipulation of Physiological Processes for Pharmaceutical Product Development

Cited by 9 publications

References 78 publications

Modeling the Effect of Composition on Formation of Aerosolized Nanoemulsion System Encapsulating Docetaxel and Curcumin Using D-Optimal Mixture Experimental Design

Modeling the Effect of Composition on Formation of Aerosolized Nanoemulsion System Encapsulating Docetaxel and Curcumin Using D-Optimal Mixture Experimental Design

Sublingual indocyanine green films for non-invasive swallowing assessment and inflammation detection through NIR/SWIR optical imaging

Pharmacokinetics and Biodistribution of Phages and their Current Applications in Antimicrobial Therapy

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