Manipulation of bio-micro/nanoparticles in non-Newtonian microflows

Tian, Fei; Feng, Qiang; Chen, Qinghua; Liu, Chao; Li, Tiejun; Sun, Jiashu

doi:10.1007/s10404-019-2232-z

Cited by 36 publications

(30 citation statements)

References 85 publications

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“…For case (i), the theoretical prediction shows modest particle migration. The experiments show negligible focusing as some particles get trapped near the channel corners, which is one of the limitations of viscoelastic focusing at low flow rates (Lu et al 2017;Tian et al 2019). Since our model is valid for two-dimensional flows, it does not account for the trapping of particles at three-dimensional corners.…”

Section: Resultsmentioning

confidence: 97%

“…However, the labour-intensive fabrication process limits the accessibility of these devices (Nam et al 2015). The more readily available rectangular microchannels 898 A20-2 A. Choudhary and others are plagued by the limitation of multiple equilibrium positions (one centre and four corners), which renders the downstream detection and separation difficult (Lu et al 2017;Tian et al 2019). Furthermore, the passive nature of the migration requires large focusing lengths which are dependent on the flow rate (D'Avino et al 2017).…”

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confidence: 99%

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Electrokinetically enhanced cross-stream particle migration in viscoelastic flows

Choudhary

Renganathan

et al. 2020

J. Fluid Mech.

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Section: Resultsmentioning

confidence: 97%

mentioning

confidence: 99%

Electrokinetically enhanced cross-stream particle migration in viscoelastic flows

Choudhary

Renganathan

et al. 2020

J. Fluid Mech.

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“…It exploits the fluid inertia-induced lift force to focus particles down to multiple or even single streams at high throughput [20][21][22][23]. Elastic focusing results from the fluid rheology-induced lift force that is capable of manipulating much smaller particles than inertial focusing [24][25][26][27]. The combination of elastic and inertial focusing can further enhance the particle control [28] and extend the working range of flow rates [29].…”

Section: Introductionmentioning

confidence: 99%

Passive Dielectrophoretic Focusing of Particles and Cells in Ratchet Microchannels

Malekanfard

Beladi-Behbahani

et al. 2020

Micromachines

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Focusing particles into a tight stream is critical for many microfluidic particle-handling devices such as flow cytometers and particle sorters. This work presents a fundamental study of the passive focusing of polystyrene particles in ratchet microchannels via direct current dielectrophoresis (DC DEP). We demonstrate using both experiments and simulation that particles achieve better focusing in a symmetric ratchet microchannel than in an asymmetric one, regardless of the particle movement direction in the latter. The particle focusing ratio, which is defined as the microchannel width over the particle stream width, is found to increase with an increase in particle size or electric field in the symmetric ratchet microchannel. Moreover, it exhibits an almost linear correlation with the number of ratchets, which can be explained by a theoretical formula that is obtained from a scaling analysis. In addition, we have demonstrated a DC dielectrophoretic focusing of yeast cells in the symmetric ratchet microchannel with minimal impact on the cell viability.

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“…where is the fluid density (assumed to be the density of the solven dilute solutions), is the average fluid speed in the main channel, We did not consider the thixotropy [78] of the prepared non-Newtonian fluids as these polymer solutions have been commonly treated as shear thinning and viscoelastic fluids in the literature [11][12][13][16][17][18]70]. However, the occurrence of low-inertia instabilities in the flow of thixotropic fluids [79] may be an interesting direction for future work.…”

Section: Methodsmentioning

confidence: 99%

Flow of Non-Newtonian Fluids in a Single-Cavity Microchannel

Raihan

Jagdale

et al. 2021

Micromachines

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Having a basic understanding of non-Newtonian fluid flow through porous media, which usually consist of series of expansions and contractions, is of importance for enhanced oil recovery, groundwater remediation, microfluidic particle manipulation, etc. The flow in contraction and/or expansion microchannel is unbounded in the primary direction and has been widely studied before. In contrast, there has been very little work on the understanding of such flow in an expansion–contraction microchannel with a confined cavity. We investigate the flow of five types of non-Newtonian fluids with distinct rheological properties and water through a planar single-cavity microchannel. All fluids are tested in a similarly wide range of flow rates, from which the observed flow regimes and vortex development are summarized in the same dimensionless parameter spaces for a unified understanding of the effects of fluid inertia, shear thinning, and elasticity as well as confinement. Our results indicate that fluid inertia is responsible for developing vortices in the expansion flow, which is trivially affected by the confinement. Fluid shear thinning causes flow separations on the contraction walls, and the interplay between the effects of shear thinning and inertia is dictated by the confinement. Fluid elasticity introduces instability and asymmetry to the contraction flow of polymers with long chains while suppressing the fluid inertia-induced expansion flow vortices. However, the formation and fluctuation of such elasto-inertial fluid vortices exhibit strong digressions from the unconfined flow pattern in a contraction–expansion microchannel of similar dimensions.

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Manipulation of bio-micro/nanoparticles in non-Newtonian microflows

Cited by 36 publications

References 85 publications

Electrokinetically enhanced cross-stream particle migration in viscoelastic flows

Electrokinetically enhanced cross-stream particle migration in viscoelastic flows

Passive Dielectrophoretic Focusing of Particles and Cells in Ratchet Microchannels

Flow of Non-Newtonian Fluids in a Single-Cavity Microchannel

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