Manipulating Metallogel Properties by Luminogens and Their Applications in Cell Imaging

Abstract

Manipulating gelation properties of the isomeric zinc–terpyridine complexes C-1 (nongelator) and C-2 (gelator) using three different luminescent dyes, viz., acridine yellow (AY), ethidium bromide (EB), and azido-boron dipyrromethene, have been described. Hybrid gels created by the combination of C-1, C-2, and above-mentioned dyes have been termed complex-luminogen mixed gels (CLMGs). Ensuing CLMGs have been thoroughly characterized by spectral, morphological, and rheological studies. Cytotoxicity measurements and imaging against breast cancer cell line MDA-MB-231 unveiled that three out of the five CLMGs can be effectively used for cell imaging. Interestingly, direct use of the metal-containing hybrid gels for live cell imaging which is a distinctive approach, has been successfully achieved with significantly encouraging results.

Preparation of Hybrid Sol-Gel Materials Based on Living Cells of Microorganisms and Their Application in Nanotechnology

“…With versatile and customizable structures, mesoporous materials based on silica [ 70 , 85 ], titanium [ 84 ], or zinc [ 113 ] are capable of loading various molecules, including pharmaceuticals, therapeutic peptides, proteins, and genes. Mesoporous silicate nanomaterials have been used as a drug delivery system for various kinds of medications with different hydrophobic or hydrophilic properties, molecular weights, and biomedical effects [ 114 ].…”

“…These medications include commonly used agents such as ibuprofen, doxorubicin, camptothecin, cisplatin, and alendronate. Peptide and protein preparations have been developed as effective therapeutic agents for many medical applications [ 84 ], including cancer therapy [ 113 ], vaccination and regenerative medicine [ 85 ]. Mesoporous silicates can protect biomolecules from premature degradation due to their porous structure.…”

Pyridoxal-based low molecular weight progelator as a new chemosensor for the recognition of Ag+ and Hg2+ under different conditions

“…86 1C. 1 Compound 2. Pyridine-4-carboxaldehyde (0.2 g, 1.86 mmol) and dehydroabietylamine (0.568 g, 2.05 mmol) were dissolved in 20 mL CH 3 OH and then the reaction mixture was heated to reflux for 4 h. After the completion of the reaction, CH 3 OH was removed by a rotary evaporator and the resulting residue was purified by column chromatography using ethyl acetate/pet ether (6 : 4, v/v) as the eluent to yield a gummy colorless substance.…”

Cu(II)-Based Nanofibrous Metallogel for Phenoxazinone Synthase-like Activity

“…The last few decades have witnessed a continuously growing interest in the fabrication of supramolecular gels, a smart functional material, encompassing fascinating physicochemical aspects. − Gels are principally self-assembled, viscoelastic, soft materials having nanoscale morphologies. From recent past, researchers are genuinely involved in their fabrication and advancement owing to their promising and wide array of applications in different branches of science and technology including catalysis, sensing, environmental pollution abatement, sorption, optoelectronics, magnetism, supercapacitors, drug delivery, cell imaging, O 2 binding and activation, and so on. − The gels are commonly having cross-linked interwoven fibrillar nanodimensional architectures, which favors the entrapment of large volume of solvent molecules, within the available annulled space of their network morphology. A couple of different coordinative and non-covalent interactions, including hydrogen bondings, hydrophobic interactions, van der Waals forces, π–π/CH−π interactions, electrostatic effects, and so forth, play the responsible role in bringing out the stable gelation.…”